3D Printing in Biomedical Research

Complementary multiphoton tools to create 3D architectures in soft hydrogels for epithelial tissue engineering.

This paper develops two complementary multiphoton-based biofabrication tools to create tunable hydrogel curvatures for epithelial tissue engineering, showing enhanced cytoskeletal organization and cell shape formation.

3D Droplet-Based Bioprinting of Customized In Vitro Head and Neck Cancer Tumor Microenvironment Models

This paper develops a 3D droplet-based bioprinting platform to create customizable in vitro head and neck cancer tumor microenvironment models, showing enhanced cell viability in functionalized matrices.

Micro-to-Macro Scale Hydrogel Microchannel Networks by Twisted Wire Templating

This paper introduces a method to create multiscale hydrogel vascular networks using twisted wire templating, achieving seamless transitions from macro- to micro-scale vessels.

A 3D Tumor-on-a-chip Platform to Identify Drugs that Block Breast Cancer Cell Intravasation

This paper develops a 3D tumor-on-a-chip platform to study and test drugs that block breast cancer cell intravasation, showing that Dactolisib reduces intravasation without harming endothelial cells.

Evaluating Preservation Techniques for Long-Term Stability of 3D Bioprinted Liver Scaffolds

This study evaluates -80°C preservation of 3D bioprinted liver scaffolds using GelMA and decellularized liver ECM, showing ~80% cell viability and preserved structure but highlighting sensitivity to preservation-induced injury.

Packed for Ossification: High-Density Bioprinting of hPDC Spheroids in HAMA for Endochondral Ossification

This paper develops a bioprinting method using hPDC spheroids in HAMA hydrogels to promote endochondral ossification for bone regeneration, showing enhanced hypertrophic cartilage formation and osteogenic differentiation.

Automated culture and monitoring of a high-throughput human heart-on-a-chip

This study develops an automated high-throughput heart-on-a-chip system using iPSC-derived cardiomyocytes and GCaMP6f for monitoring, showing a temperature-dependent decrease in beat rate.

Modular Integration of Impedance Sensing for Real-Time Assessment of Barrier Integrity

This paper introduces a modular system for real-time assessment of barrier integrity using impedance sensing in microphysiological systems.

Volumetric Bioprinting of Bone-like Mineralizing Hydrogel Constructs in the Presence of High Cell Densities and Mineral Precursors

This study combines volumetric bioprinting with mineralization to create high-density cell-laden hydrogel constructs with bone-like properties.

Automated high-throughput fabrication of patient-specific vessel-on-chips enables a generative AI digital twin--Cascade Learner of Thrombosis (CLoT) for personalized thrombosis prediction

The paper develops a platform for automated vessel-on-chip fabrication and a generative AI model, CLoT, to predict thrombosis in patients with high accuracy.

Multiscale computational framework for generating vascularizedbiohybrid tissue constructs

This paper introduces a computational framework for designing vascular networks in biohybrid tissues, enabling 3D-printing of complex, hierarchical vasculature with biological and synthetic constraints.

Photopatterned Sacrificial Vascular Architectures for Large Tissue-Scale Oxygenation

This paper introduces pCAST, a method to create perfusable vascular networks in 3D tissues, and shows it improves oxygen distribution and tissue viability.

Low-Cost, Rapid Fabrication of Customizable Polyethylene Glycol-Based Cell Culture Devices

This paper develops a low-cost, rapid method for fabricating PEG-based cell culture devices using 3D printing and PDMS molds, enabling customizable microphysiological systems for tissue engineering.

Embedding Perfusable Microchannel Networks in Photoclickable Bioresins via High-Resolution Digital Light Processing

This paper develops a biocompatible photoresin for 3D bioprinting perfusable microvascular networks using digital light processing.

A scalable tumor-vasculature-on-chip for CAR T cell trafficking and efficacy studies

This paper describes a scalable tumor-vasculature-on-chip platform to study CAR T cell trafficking and efficacy in a 3D tumor microenvironment.

A 4D Bioprinting Platform to Engineer Anisotropic Musculoskeletal Tissues by Spatially Patterning Microtissues into Temporally Adapting Support Baths

This paper introduces a 4D bioprinting platform that engineers anisotropic musculoskeletal tissues by controlling support bath stiffness to direct cell behavior and matrix organization.

Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

The paper combines an organ chip platform with deep learning for drug response analysis in cancer models, showing improved accuracy over traditional methods.

A Vascularized Liver Microphysiological System Captures Key Features of Hepatic Insulin Resistance and Monocyte Infiltration

This paper develops a vascularized liver microphysiological system to model hepatic insulin resistance and monocyte infiltration, showing altered metabolism, vascular changes, and immune cell recruitment.

Shaping hydrogel bioinks into 3D, multiscale, perfusable models using multimodal printing

This paper develops a hybrid 3D printing platform combining digital light projection and two-photon ablation to create multiscale, perfusable hydrogel constructs that mimic in vivo-like structures.

A 3D printed model of human lactation

This paper develops a 3D printed model of human lactation using FLight biofabrication to create hormone-responsive mammary microtissues.

Artificial capillaries-on-a-chip with modular control over lumen size, architecture, in situ modifications and co-culture conditions.

This paper introduces a microfluidic chip technology for creating artificial capillaries with controlled lumen size, architecture, and co-culture conditions, enabling reproducible microvascular biology studies.

A 3D-printed pump-free multi-organ-on-a-chip platform for modeling the intestine-liver-muscle axis

This paper presents a 3D-printed, pump-free multi-organ-on-a-chip device that models the intestine-liver-muscle axis by enabling dynamic co-culture of three cell types with improved metabolic functions.

Vascularized tumor organoids enable immunotherapy testing in tumor-remodeled stroma

This paper introduces vascularized tumor organoids (VascO) to model tumor microenvironments for immunotherapy testing, showing they can assess drug safety and efficacy in a patient-specific context.

Human fallopian tube-on-a-chip for preclinical testing of non-hormonal contraceptives with living human sperm

The paper develops a human fallopian tube-on-a-chip model to test non-hormonal contraceptives, showing dose-dependent sperm motility inhibition by TDI-11861.

BLOC: buildable and linkable organ on a chip

The paper introduces BLOC, a modular organ-on-a-chip system that allows flexible configuration for diverse applications in MPS research.

A Versatile, Biocompatible Additive for Spatiotemporal Volumetric Photografting of Biochemical and Mechanical Cues in Diverse Hydrogel Matrices

This paper introduces AddGraft, a biocompatible additive enabling spatiotemporal modification of hydrogel properties for 3D tissue engineering.

Dityrosine photocrosslinking of native collagen bioinks for controlled shape-fidelity of bioprinted cardiac tissue constructs: probing the interplay between fibrillogenesis and covalent bond formation

This paper develops a photocrosslinking method to stabilize collagen bioinks for bioprinted cardiac tissue, enabling tunable shape fidelity through dityrosine bonds.

Anatomically and Physiologically Accurate Engineered Neurovascular Unit and Blood-Brain Barrier Model Using Microvessels Isolated from Postmortem Human Brain Tissue

The paper develops a human brain vasculature-on-a-chip model using microvessels from postmortem tissue, demonstrating anatomical and physiological features of the blood-brain barrier.

Integrating 3D Tumor Models and Microfluidics for Precise Metabolic Control

This paper introduces MilliFlow3D, a microfluidic platform that generates controlled metabolic gradients to study tumor behavior under metabolic deprivation.

Integrated Microfluidic Platform for High-Throughput Generation of Intestinal Organoids in Hydrogel Droplets

The paper introduces a microfluidic platform for high-throughput generation of uniform intestinal organoids in hydrogel droplets, achieving high homogeneity and reproducibility.