Immune cells in cancer

This study identifies lactate as a key factor in AML-induced immunosuppression by polarizing leukemia-associated macrophages via GPR81 signaling.

This study shows ovarian cancer drives TLR5-dependent expansion of myeloid progenitors through systemic dissemination of ligands, leading to increased monocyte and macrophage accumulation in the tumor microenvironment.

This study identifies tumor-initiating cells that modulate neutrophil plasticity to create a protective niche, preventing immunotherapy effectiveness.

The paper uses in vitro macrophage polarization data to identify an IFNγ signature in active Crohn's disease intestinal inflammation.

This study identifies CD300e as a driver of immunosuppressive tumor microenvironment in colorectal cancer by reprogramming macrophages to suppress T-cell function and promote tumor growth.

This study identifies three subpopulations of colonic macrophages in mice, showing they persist through inflammation and adapt transcriptionally to aid tissue repair.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

This study shows that GM-CSF expression in melanoma and tumor-associated macrophages correlates with poor prognosis and promotes metastasis through pro-inflammatory signaling.

This study identifies high M2-TAM infiltration as an independent poor survival prognostic factor in meningiomas, overriding the beneficial effect of TILs.

This study shows that older females have more inflammatory monocytes, which is reversed by Hormone Replacement Therapy.

The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

This study investigates how adjuvant conditioning affects peritoneal macrophages and neutrophils, revealing a suppressive macrophage phenotype and enhanced neutrophil function.

This study shows hypoxia alters myeloid cell functions in glioblastoma by changing gene expression and chromatin accessibility, affecting immune cell markers and transcription factor regulation.

The paper identifies BIGH3 as a macrophage-secreted driver of GBM invasion using a 3D model and shows its inhibition reduces GSC invasion.

This study shows that inhibiting PU.1 in mice reduces tumor growth by increasing cytotoxic lymphocyte recruitment via the CXCL9-CXCR3 axis.

This study shows that CD24a knockout in murine triple-negative breast cancer cells transforms the tumor microenvironment from cold to hot by increasing immune cell infiltration and reducing suppressive cells.

This study shows that Kabasura Kudineer Choornam modulates human macrophage polarization and phagocytic function by altering marker expression and cytokine secretion.

The paper identifies Clindamycin as a potential inhibitor of pyroptosis in tumor-associated macrophages by integrating network biology and pharmacophore modeling.

The paper identifies two distinct neutrophil clusters with unique immune features across diverse disease conditions in mouse models.

This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.

The paper identifies human myelocyte and metamyelocyte-stage neutrophils as immunosuppressive cells that promote cancer progression and suggests targeting them for immunotherapy.

This study identifies S100a4+ alveolar macrophages that promote lung cancer progression by enhancing angiogenesis through fatty acid metabolism in precancerous lesions.

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

This study investigates the role of immunosuppressive neutrophils in SBRT-treated murine PDAC and shows that re-wiring them with IL-12 improves treatment efficacy.

The paper identifies tumor-inhibitory fibroblasts that produce fibronectin, which activates signaling pathways in neighboring cells to enhance immune response against early cancer.

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

This study shows that macrophage clusters enhance tumor phagocytosis through coordinated intrudopodia extending between cancer cells.