Invertebrate Immune Response Mechanisms

Vibrio cholerae colonization of the arthropod intestine activates innate immune signaling in enteroendocrine cells via phosphorylation of the nuclear receptor ultraspiracle

This study shows that Vibrio cholerae uses tryptophan to activate serotonin signaling in arthropod enteroendocrine cells, leading to IMD pathway activation and enhanced colonization.

An updated proteomic analysis of Drosophila hemolymph after bacterial infection

This study uses proteomics to analyze Drosophila hemolymph after bacterial infection, identifying new proteins and changes in mitochondrial respiration.

Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans

The paper identifies chromatin regulators in C. elegans that repress immune responses to intracellular pathogens, linking developmental regulation to immune control.

Insects fight low-dose infections with terminal investment, not innate immunity

This study shows insects combat low-dose infections through terminal investment, not innate immunity, by sacrificing reproduction for survival.

Evolutionary history with chronic malnutrition enhances pathogen susceptibility at older ages

The study shows that chronic juvenile malnutrition in Drosophila leads to improved early-life pathogen tolerance but increased late-life infection susceptibility.

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense

The paper identifies ruptoblasts, a novel cytotoxic cell type in planarians, showing they use explosive cell death to release cytotoxic agents in response to activin, linking hormonal regulation to immune defense.

Transcriptomic landscape reveals immunity related trade-offs in an invertebrate-fungal host-parasite system

The paper examines immune responses and life-history trade-offs in a Daphnia magna - Metschnikowia bicuspidata host-parasite system using transcriptomics and life-history trait measurements.

Layers of immunity: Deconstructing the Drosophila effector response

This study systematically evaluates the roles of four immune modules in Drosophila by deleting them individually and collectively, revealing their independent and synergistic contributions to defense against various pathogens.

Decoding host responses: How a freshwater invertebrate defends against a parasitic bacterium

This study investigates the immune response of Daphnia magna to the parasitic bacterium Pasteuria ramosa, revealing key immune genes and pathways involved in host defense and parasite restriction.

Cryopreservation Enables Long-Term Studies of Octopus vulgaris Hemocyte Immune Functions

This study demonstrates that cryopreserved Octopus vulgaris hemocytes maintain viability above 80% and functional phagocytic ability for at least two months, enabling long-term immune function studies.

A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans

The paper identifies spia-1 as a gene involved in immune activation in C. elegans by sensing cuticle damage through its secreted protein with a novel cysteine-cradle domain.

Unusual traits shape the architecture of the Ig ancestor molecule

The paper identifies novel Ig-domain features in Porifera, suggesting potential primitive adaptive immunity mechanisms.

Resources modulate developmental shifts but not infection tolerance upon coinfection in an insect system

The paper investigates how dietary resources affect developmental shifts and infection tolerance in flour beetles coinfected with gregarine and bacterial parasites, finding that resources modulate developmental timing but not resistance to bacterial infection.

Timing of starvation determines its effects on susceptibility to infection in Drosophila melanogaster females independent of host evolutionary history

This study shows that the timing of starvation affects Drosophila melanogaster's susceptibility to E. faecalis infection, with post-infection starvation improving survival regardless of prior treatment.

Fungi activate Toll-1 dependent immune evasion to induce cell loss in the host brain

This study shows that the fungus Beauveria bassiana causes cell loss in the Drosophila brain through Toll-1/Wek/Sarm signaling, which drives immune evasion.

Single-Cell RNA Sequencing Reveals Hemocyte Heterogeneity, Differentiation Trajectories, and Viral Tropism in Shrimp (Macrobrachium rosenbergii) Infected with Decapod Iridescent Virus 1

This study uses single-cell RNA sequencing to analyze hemocyte subpopulations in shrimp infected with DIV1, identifying transcriptional heterogeneity, differentiation trajectories, and antiviral immune responses.

The chromosome-level genome of the ctenophore Mnemiopsis leidyi A. Agassiz, 1865 reveals a unique immune gene repertoire

The paper presents a chromosome-level genome of Mnemiopsis leidyi, revealing unique immune gene domains and their expression in response to pathogen exposure.

ATG-3 limits Orsay virus infection in C. elegans through regulation of collagen pathways

The paper shows ATG-3 limits Orsay virus infection in C. elegans by regulating collagen pathways, independent of autophagic flux.

Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector

This study examines immune gene expression in African snails exposed to Schistosoma mansoni and evaluates diet effects on gene expression.

Chronic infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and superinfection exclusion

This study investigates how chronic Orsay virus infection in C. elegans leads to age-dependent immunity and superinfection exclusion.

A Nonsecretory Antimicrobial Peptide Mediates Inflammatory Organ Damage in Drosophila Renal Tubules

This study identifies Attacin-D as a nonsecretory antimicrobial peptide that mediates immune-induced organ damage in Drosophila renal tubules upon Imd pathway activation.

Retracing the horizontal transfer of a novel innate immune factor in Drosophila

This study uses genome editing in Drosophila to trace the evolution of horizontally transferred immune toxins, showing fusionB enhances survival and suppresses parasitoid wasp development.

Bacterial sensing via Neuronal Receptor Initiates Gut Mitochondrial Surveillance for Host Adaptation

The paper identifies a bacterial sensing mechanism in neurons that activates intestinal mitochondrial surveillance to protect against infections.

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

The paper shows that the SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response in Drosophila larvae during parasitoid wasp infection.

Evolution of g-Type Lysozymes in Metazoa: Insights into Immunity and Digestive Adaptations

This study investigates the evolutionary distribution and functional diversification of g-type lysozymes across metazoans, revealing lateral gene transfer and specialized roles in immunity and digestion.

Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila

The paper shows that Pkc53E-mediated phosphorylation of Su(H) inhibits Notch signaling, enabling Drosophila to mount an effective immune response against parasitic wasps.

Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans.

This paper identifies two C-type lectin receptor pairs in C. elegans that mediate recognition of specific oomycete pathogens and show they are co-regulated and function redundantly in host defense.

Exploring new dimensions of immune cell biology in Anopheles gambiae through genetic immunophenotyping

The paper characterizes mosquito hemocytes using genetic markers and morphological properties, identifying twelve distinct populations in Anopheles gambiae.

Genetic and functional diversity of allorecognition receptors in the urochordate, Botryllus schlosseri

The paper identifies and characterizes a diverse family of allorecognition receptors in Botryllus schlosseri, revealing their genetic complexity and conserved signaling mechanisms.

On pathogenicity with varying microbial virulence and host resistance

The paper compares methods for assessing pathogenicity using Drosophila and Providencia bacteria, highlighting advantages and limitations of different statistical approaches.