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A Modularized Stretchable Microneedle Array for Minimally Invasive and Efficient Drug Delivery

The paper develops a modularized stretchable microneedle array for efficient drug delivery, showing improved penetration rates and reduced residual strain in porcine skin.

Lung-Targeting Interleukin-10 mRNA Lipid Nanoparticles Ameliorate Acute Lung Injury

This study develops lung-targeted IL-10 mRNA lipid nanoparticles that reduce acute lung injury in a mouse model by attenuating inflammation and tissue damage.

Preserving Integrity: Innovative In Vitro Methods for Extracellular Matrix Decellularization and Collagen Purification

The paper develops and validates new methods for ECM decellularization and collagen purification that preserve structural and biochemical integrity, applicable to various cell types for tissue engineering and drug discovery.

Cellular-resolution OCT reveals layer-specific retinal mosaics and ganglion cell degeneration in mouse retina in vivo

This study develops a WSAO-OCT platform to visualize retinal cells in live mice, showing improved image quality and detecting RGC degeneration after optic nerve injury.

A Versatile, Biocompatible Additive for Spatiotemporal Volumetric Photografting of Biochemical and Mechanical Cues in Diverse Hydrogel Matrices

This paper introduces AddGraft, a biocompatible additive enabling spatiotemporal modification of hydrogel properties for 3D tissue engineering.

Regularized Single-cell Imaging Enables Generalizable AI models for Stain-free Cell Viability Screening

Regularized single-cell imaging in nanowells enables training of generalizable AI models for accurate, stain-free viability screening across previously unseen cell types and contexts.

Multi-parametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the Langendorff-perfused heart

The paper develops a multi-parametric imaging system to study cAMP, transmembrane potential, and calcium in the heart, showing cAMP activation correlates with electrophysiological responses.

Advanced 3D spheroid-based skin models and deep-learning based image analysis enable in-depth investigation of keratinocyte differentiation and barrier function

The paper introduces 3D spheroid-based skin models and a deep-learning pipeline to study keratinocyte differentiation and barrier function, identifying NHK-E6/E7 as the best alternative to primary keratinocytes.

A scalable organoid model of urothelial aging for metabolic interrogation, infection modeling, and reversal of age-associated changes

This study introduces a scalable organoid model of urothelial aging to investigate metabolic changes and test interventions for age-related bladder dysfunction.

Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

Spatial Image Gradient Estimation from the Diffusion MRI Profile

This paper estimates spatial image gradients from diffusion MRI signals by modeling relaxation-time properties, showing significant correlation with gold-standard gradients across multiple datasets.

Functional Human Retinohypothalamic Tract Assembloid Model for Circadian Rhythm Research

This paper develops a functional human retinohypothalamic tract assembloid to study circadian rhythms, showing synchronized network activity and self-sustained gene expression oscillations.

Tailored Cell Cycle Modulation Enhances AAV Manufacturing: Balancing Arrest with Adaptive Stress Responses

This study evaluates how cell-cycle arrest and stress pathways affect rAAV production, finding that tailored modulation improves yields.

3D Microscale Mechanical Simulations of Hydrogel Coated Electrospun Meshes

This paper uses 3D microscale mechanical simulations to predict bulk mechanical properties of hydrogel-coated electrospun meshes, revealing non-affine deformations and stress-strain differences.

IMAGENE: Single-cell association of live cell imaging and gene expression profiles of non-adherent cells through photoactivatable adhesives

The paper introduces IMAGENE, a pipeline that links live cell imaging and gene expression in non-adherent cells using photoactivatable adhesives and machine learning.

Computational Analysis of Structure and Binding Energy forCisplatin-Loaded Proteins

This paper uses computational methods to analyze cisplatin binding in proteins, evaluates engineered MSH6 carriers, and compares DNA binding energies of protein-delivered versus systemic cisplatin.

Layer-by-Layer Polymeric Films: A Novel Approach to Buccal GLP-1 Delivery

This paper develops multilayer polymeric films for buccal delivery of GLP-1-RA and GDC, showing that triple-layer films provide sustained release and better mucosal compatibility than dual-layer films.

Investigating the Impact of Hypoxia and Syncytialization on Lipid Nanoparticle-Mediated mRNA Delivery to Placental Cells

This study evaluates how hypoxia affects lipid nanoparticle-mediated mRNA delivery to placental cells and shows that therapeutic mRNA can restore protein levels under hypoxic conditions.

A {lambda} Phage Platform for Successful Therapeutic Display of Protein Antigens

This paper develops a lambda phage platform for displaying protein antigens and demonstrates its success in antigen selection and immunotherapy in a mouse model.

Engineering a performance-improved, axon-targeted kalium channelrhodopsin for optogenetic neuropathway inhibition

The paper improves an optogenetic silencer for axonal inhibition, showing enhanced performance and axonal targeting in mouse models.