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Molecular Glue-like Degraders of TEM β-Lactamases by Periplasmic Protease DegP

This study develops molecular glue-like degraders that target TEM β-lactamases for degradation by DegP, showing improved synergy with piperacillin against resistant E. coli.

Comparative Evaluation of Commercial Gradient Diffusion and Disk Diffusion Tests for Aztreonam-Avibactam Susceptibility Testing

This study compares four commercial AZA susceptibility testing methods for carbapenem-resistant Enterobacterales, finding acceptable performance with minor errors mainly in breakpoint-adjacent isolates.

Assessing the Operational Feasibility of Evolutionary Therapy in Metastatic Non-Small Cell Lung Cancer

This study evaluates the clinical feasibility of evolutionary therapy for NSCLC by simulating its performance under real-world constraints like measurement error and appointment delays.

Pressure-induced membrane tension mechanically opens the germinant receptor GerA ion channel to trigger bacterial spore germination

This study shows that pressure-induced membrane tension opens the GerA ion channel in Bacillus subtilis spores, triggering germination through a stretch-to-open mechanism.

Degeneracy in neuronal bifurcation landscapes: equivalent bifurcation sequences across distinct parameter sets

The paper shows that different biophysical parameters can produce equivalent bifurcation sequences in neuronal models, revealing degeneracy in neuronal dynamics.

A Computational Model of Mechanical Stretching of Cultured Cells on a Flexible Membrane

This paper develops a computational model to simulate mechanical stretching of cultured cells on a flexible membrane and connects it to chromatin deformation.

Repeatability of adaptation in interacting species

This study investigates how intergenomic epistasis affects endpoint repeatability in coevolving species, finding high repeatability within landscapes but varying fitness outcomes across landscapes.

Aβ42 facilitates the activation of Discoidin Domain Receptor 2 and Its nuclear enrichment in Alzheimer's Disease Model

This study shows Aβ42 activates DDR2 in Alzheimer's disease models by non-canonically bypassing collagen ligands and promotes its nuclear enrichment, with structural insights into the mechanism and potential therapeutic inhibition.

Mapping the sequence preference of the generalist class II lanthipeptide synthetase ProcM by mRNA display

This study maps the sequence preferences of the generalist class II lanthipeptide synthetase ProcM using mRNA display and machine learning, revealing moderate predictive accuracy compared to specialized enzymes.

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins

This study shows the ER membrane protein complex (EMC) acts as a chaperone to facilitate the assembly of voltage-gated calcium channels during their biogenesis.

Rapid updating of ecological information in wild Guinea baboons

This study shows Guinea baboons adjust their space-use and foraging behavior in response to changes in food availability caused by a wildfire.

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

This study identifies SVEP1 as a mediator of ANG2-TIE1 binding, leading to TIE1 phosphorylation and downstream signaling in lymphatic endothelial cells.

Soil nitrogen dynamics in riparian zones of two Arctic rivers

This study quantifies nitrogen cycling in Arctic riparian zones, revealing active mineralization and denitrification despite low temperatures and organic carbon content.

Substrate recognition and ion coupling mechanism of the human VIAAT

The paper determines the structures of human VIAAT in multiple functional states and elucidates its substrate recognition and ion coupling mechanism.

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase

The paper identifies potent reaction hijacking inhibitors targeting Plasmodium falciparum asparagine tRNA synthetase, showing high selectivity and resistance refractoriness.

kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis

This study identifies kri-1/KRIT1 as a regulator that limits skn-1/NRF2 activity to control immune responses and lipid homeostasis in C. elegans, supporting reproductive health.

The Endothelial Cell-Expressed Prion Protein Prnd/Doppel Promotes Neovascularization and Long-term Recovery after Ischemic Stroke

This study shows that Prnd/Doppel in endothelial cells promotes vascular remodeling and long-term recovery after stroke, improving neuronal survival and reducing inflammation.

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

PD-L1 deletion or blockade regulate macrophage antigen presentation and checkpoint molecule surface levels

This study investigates how PD-L1 deletion or blockade affects macrophage antigen presentation and checkpoint molecule levels in different polarization states.

Multivariate Mutual Information based Feature Selection for Predicting Histone Post-Translational Modifications in Epigenetic Datasets

This paper introduces multivariate mutual information (MMI) for selecting histone PTM features to predict epigenetic data, showing improved accuracy over traditional methods.