A. Singh

Coevolution of retroviruses with SERINCs following whole-genome duplication divergence

This study investigates the coevolution of retroviruses with SERINC proteins, showing functional conservation among SERINC paralogs and the role of whole-genome duplication in shaping anti-retroviral activity.

Organoid Polymer Functionality and Mode of Klebsiella Pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells

The paper develops PEG-organoids to study how polymer chemistry and antigen presentation affect germinal center-like B cell epigenetics in young and aged mice.

Optimum Threshold Minimizes Noise in Timing of Intracellular Events

The paper studies how noise in holin expression affects lysis timing in E. coli infected by bacteriophage λ, finding that noise decreases to a minimum and then increases with lysis time.

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway

The paper identifies RASSF proteins as effectors linking RAS GTPases to the Hippo pathway, showing specificity in binding and regulatory roles.

Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells

This study shows salinomycin inhibits EZH2 in colon CSCs, enhancing DR4/DR5 expression and reducing CSC traits, suggesting a therapeutic strategy combining TRAIL and EZH2 inhibitors.

Stoichiometric Analysis of Protein Complexes by Cell Fusion and Single Molecule Imaging

The paper introduces a method to quantify protein complex stoichiometry in live cells by diluting complexes in situ before single-molecule imaging, avoiding artifacts from detergent isolation or low expression levels.

Host-induced silencing of the Colletotrichum gloeosporioides conidial morphology 1 gene (CgCOM1) confers resistance against Anthracnose disease in chilli and tomato

This study uses Host-Induced Gene Silencing to silence a fungal gene, reducing anthracnose disease in chilli and tomato.

Robust lysosomal rewiring in Mtb infected macrophages mediated by Mtb lipids restricts the intracellular bacterial survival

The paper shows that Mtb lipids induce lysosomal rewiring in infected macrophages, enhancing host defense and restricting bacterial survival.

CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5

The paper shows that intracellular CXCR4 protein, not its signaling, promotes drug resistance and tumorigenicity by downregulating DR5 through transcription factor modulation.

Insights into ancestry and adaptive evolution of the Mycobacterium tuberculosis complex from analysis of the emerging pathogen Mycobacterium riyadhense

This paper characterizes the genome of Mycobacterium riyadhense, showing it shares ancestry with Mycobacterium tuberculosis and provides insights into the evolutionary path of the MTBC.

Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling

This study quantifies HTLV-1 reactivation kinetics using single-molecule RNA FISH and stochastic modeling, revealing rapid sense-strand transcription bursts and stable antisense transcription.

Targeting AGTR1/NF-κB /CXCR4 axis by miR-155 attenuates oncogenesis in Glioblastoma

This study shows miR-155 targets AGTR1's 3UTR, reduces AGTR1-mediated oncogenic processes, and suppresses tumor growth in GBM models.

Mitogen-independent cell cycle progression in B lymphocytes

This study shows B lymphocytes can undergo multiple mitosis-independent divisions after the first mitosis, driven by unique G1 phase characteristics and limited by apoptosis, with Birc5 playing an essential role.

Validation and characterisation of a wheat GENIE3 network using an independent RNA-Seq dataset

The paper validates a wheat GENIE3 network using an independent RNA-Seq dataset, showing significant overlap between predicted targets and differentially expressed genes for NAM-A1.

Mycobacterium tuberculosis reactivates HIV via exosomes mediated resetting of cellular redox potential and bioenergetics

This study shows that Mtb exosomes reactivate HIV-1 by altering redox potential and bioenergetics, with antioxidant and host factor inhibitors reducing reactivation.

The histidine kinase PdtaS is a cyclic di-GMP binding metabolic sensor that controls mycobacterial adaptation to nutrient deprivation

The paper identifies PdtaS as a c-di-GMP binding histidine kinase that regulates mycobacterial adaptation to nutrient deprivation through transcriptional and metabolic changes.

Phytoplasma SAP11 effector destabilization of TCP transcription factors differentially impact development and defence of Arabidopsis versus maize

This paper shows that SAP11 effectors from different phytoplasmas differentially destabilize TCP transcription factors, leading to distinct developmental and defense outcomes in Arabidopsis and maize.

The Mut+ strain of Komagataella phaffii (Pichia pastoris) expresses PAOX1 5 and 10 times faster than Muts and Mut- strains: Evidence that formaldehyde or/and formate are true inducers of AOX.

Cholesterol Myth and the Imperative Role of Functional Evaluation of Lipoproteins in Atherosclerotic Risk Prediction Strategies

The paper compares traditional and functional lipoprotein markers to predict atherosclerotic risk in diabetic and cardiovascular patients.

pH controlled histone acetylation amplifies melanocyte differentiation program downstream of MITF

The paper identifies a pH-controlled histone acetylation mechanism downstream of MITF that amplifies melanocyte differentiation by modulating chromatin dynamics.

Visual signal evolution along complementary color axes in four bird lineages

The paper examines color pattern evolution in four bird lineages, showing plumage colors cluster along complementary color axes and that color variation is not constrained by phylogenetic relatedness.

Mycobacterium ulcerans in Mosquitoes and March flies captured from endemic areas of Northern Queensland, Australia

The paper screens mosquitoes and March flies from northern Queensland for Mycobacterium ulcerans DNA and finds one positive mosquito pool and no positive March fly samples, with evidence of mechanical transmission via proboscises.

Helicase Promotes Replication Re-initiation from an RNA Transcript

This study shows that T7 helicase can restart DNA replication from an RNA transcript without replication restart proteins or primase.

Synaptic transmission may provide an evolutionary benefit to HIV through modulation of latency

This paper introduces a mathematical model of HIV replication that includes both free virus and cell-cell transmission pathways, showing that cell-cell transmission suppresses latency and provides an evolutionary benefit to HIV.

Redox-Dependent Condensation Of the Mycobacterial Nucleoid By WhiB4

This paper identifies WhiB4 as a redox-dependent nucleoid condensing protein in Mtb that links oxidative stress response with genome organization and gene expression.

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.

Frequency-dependent response of Chromobacterium violaceum to sonic stimulation, and altered gene expression associated with enhanced violacein production at 300 Hz

This study shows that 300 Hz sonic stimulation increases violacein production in Chromobacterium violaceum by up-regulating genes involved in glucose metabolism and tryptophan synthesis.