C. Chen

Dynamic Changes of G-CSF etc. Nine Cytokines in Mouse Bloodstream Infection Models of Staphylococcus aureus and Klebsiella pneumoniae and their Clinical Performances

This study monitors cytokine dynamics in mouse infection models and evaluates their diagnostic performance for bacterial bloodstream infections.

Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

Extension of the in vivo haploid induction system from diploid maize to hexaploid wheat

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity

This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.

Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance

The paper identifies new MmpL3 inhibitors through screens and analyzes resistance mutations to define clades of inhibitors and mutants with differential resistance.

Effectiveness of Genomic Selection by Response to Selection for Winter Wheat Variety Improvement

This study evaluates genomic selection effectiveness for winter wheat improvement by assessing prediction accuracy and response to selection across different environmental conditions.

Genome-wide identification and expression specificity analysis of the DNA methyltransferase gene family under adversity stresses in cotton

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

TP53 mutations promote immunogenic activity in breast cancer

This study finds that TP53 mutations in breast cancer increase immunogenic activity, suggesting they could be a biomarker for immunotherapy response.

Ascitic bacterial composition is associated with clinical outcomes in cirrhotic patients with culture-negative and nonneutrocytic ascites

The paper analyzes ascitic microbiota composition in cirrhotic patients and finds two microbial clusters associated with different clinical outcomes, particularly higher short-term mortality in one cluster.

Nuclear import of Arabidopsis POLY(ADP-RIBOSE) POLYMERASE 2 is mediated by importin-α and a nuclear localization sequence located between the predicted SAP domains

The paper identifies a nuclear localization sequence in Arabidopsis PARP2 that mediates its import via importin-α and the importin-β pathway.

Antimicrobial Efficacy and Safety of a Novel Gas Plasma-Activated Catheter Lock Solution

This study evaluates a novel antibiotic-free gas plasma-activated catheter lock solution, showing it effectively eradicates biofilm microbes and is less toxic to human cells than a standard solution.

A multi-scale model of the yeast chromosome-segregation system

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

The paper identifies a novel mechanism where the cytokine receptor Dome interacts with Eb1 to regulate spindle orientation in Drosophila GSCs, linking cell polarity to fate without involving the JAK-STAT pathway.

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo

The paper uses cryo-ET to study nucleosome organization in fission yeast mitotic chromosomes, revealing cluster and megacomplex structures and explaining gene expression patterns during mitosis.

Conformational dynamics of Cas9 governing DNA cleavage revealed by single molecule FRET

This study uses single molecule FRET to show Cas9 undergoes conformational changes and long-range allosteric communication that regulate DNA cleavage, identifying key residues for improving CRISPR/Cas9 specificity.

A group of nuclear factor Y transcription factors are likely sub-functionalized in the endosperm development of monocot

This study identifies and characterizes NF-Y transcription factors involved in rice endosperm development, showing sub-functionalization and interaction patterns among subunits.

Characterization Of Imprinted Genes In Rice Reveals Post-Fertilization Regulation And Conservation At Some Loci Of Imprinting In Plant Species

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.

Natural Chromatin Is Heterogeneous And Self Associates In Vitro

This study investigates the structure of natural chromatin in vitro using cryo-ET, showing it forms compact masses with rare 30-nm fibers and is sensitive to divalent cations and histone modifications.

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.

Contrasting determinants of mutation rates in germline and soma

The paper compares mutation rate determinants in germline and somatic tissues, finding shared factors but contrasting effects of expression levels on mutation rates in ovaries/testes versus tumors.