K. Liu

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

This study shows tegaserod maleate inhibits gastric cancer growth by targeting MEK1/2 in vitro and in a mouse model, with effects comparable to trametinib.

This study shows that GC activates STING and enhances type I IFN and IL-1β production, promoting antitumor and antiviral immune responses.

This study investigates how two Keap1 isoforms, α and β, differentially inhibit Nrf2 and influence malignant behaviors in hepatocellular carcinoma.

This paper designs a novel peripheral intravenous catheter (FloRamp) to reduce early failure rates and reports preliminary results from animal testing showing reduced occlusion and lower phlebitis scores.

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

This paper proposes and tests a calibration protocol for crop phenology models, reducing prediction error and team variability by 22%.

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.

This study identifies chloroplast-specific factors AtRsmD and AtRimM essential for 16S rRNA maturation and chloroplast proteostasis in Arabidopsis thaliana.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study presents a synthetic ECM with high-affinity integrin-selective peptides that promote rapid stem cell spreading compared to traditional RGD or Matrigel controls.

This paper develops a lightweight deep learning model to automatically identify chicken distress calls, achieving high accuracy with reduced computational requirements.

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study models protein corona formation on LNPs and identifies time-dependent steps that affect their uptake and mRNA delivery, showing that pre-incubation in serum can eliminate a lag-time.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

This study investigates the differential and cooperative roles of Nrf1 and Nrf2 in regulating antioxidant gene expression and cytoprotective responses to tBHQ-induced oxidative stress in human cell lines.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.