K. Liu

This study shows oxaliplatin-resistant colorectal cancer cells become more sensitive to TRAIL due to increased DR4 expression, palmitoylation, and lipid raft localization.

The paper identifies reduced ER-mitochondria contacts as a mechanism promoting neuroblastoma multidrug resistance by impairing Ca2+ transfer and apoptosis.

This study shows that HIV-1 signal peptide diversity affects Env glycosylation and antibody recognition of V1V2 epitopes.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study combines CRISPR activation and binary colloidal crystals to enhance the rapid differentiation of human iPSCs into neurons.

This study shows that pharmacologically lowering amino acid pools in yeast extends lifespan by inhibiting TORC1 signaling through sphingolipid-dependent mechanisms.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This study uses scRNA-seq to show that LIT induces proinflammatory cytokine signaling and immune cell activation in tumor microenvironments of MMTV-PyMT mice.

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

The paper models how motor activity and crosslinks generate dynamic nuclear structure and chromosome motions.

This study shows that expressing LaNt 31 during mouse development causes tissue-specific defects and basement membrane disruption, supporting a model of laminin self-regulation.

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

The paper shows that the G-domain of elongation factor G remains unfolded during synthesis and folds after exiting the ribosome, following a C-to-N terminal folding pathway.

This study identifies RSK-ABCB1 and HIF-1-FECH pathways regulated by MEK that reduce PpIX accumulation in cancer cells.

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

This study identifies four clinically used drugs with high binding capacity to SARS-CoV main protease, a potential target for treating 2019-nCoV infection.

This study classifies RNase H-like domain-containing proteins in plants, identifying 27 clusters and highlighting their potential roles in DNA replication, RNA transcription, and nucleic acid degradation.

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

The paper introduces GLAMS, a method using glycosyltransferase labeling and mass spectrometry to identify sialylation linkages at the glycopeptide level, successfully identifying 1,236 linkage-specific sialoglycopeptides from human serum.

This study examines how substrate stiffness affects human umbilical vein endothelial cell behavior, finding increased CX40 and GAG content and decreased actin stress fibers and proliferation on stiff substrates.

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.

This study compares genomic features of BRCA1/BRCA2-mutated breast tumors with sporadic tumors, finding differences in mutation patterns, DNA methylation, and structural variation.

The paper identifies a conserved (p)ppGpp binding motif in HPRT across species, showing that ligand binding varies with dimer-dimer interactions that evolved to regulate purine homeostasis.

The paper shows that PNP-A antagonizes SA-mediated cell death in Arabidopsis lsd1 mutants by interacting with a newly identified receptor PNPAR.