L. Xu

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

This study examines how HE4 contributes to hyperoxia-induced alveolar damage in rats by activating ERK and p65, modulating MMP9 and TIMP1 pathways, and promoting fibrosis.

This study identifies VCAM-1 upregulation as a key marker of AKI-to-CKD transition, distinct from KIM-1, through mouse models and human single-cell transcriptomics.

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The paper defines cancer epithelial and immune cell heterogeneity in breast tumors using single-cell RNA-seq and develops a tool to predict anti-PD-1 therapy response.

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

This study examines how cochlear implant materials affect macrophage and fibroblast function and fibrous tissue growth, finding greater fibrosis and bone formation around platinum compared to PDMS.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study shows that persistent macrophages after AKI promote a proinflammatory environment leading to tubule damage and CKD progression.

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

This paper proposes a computational method to track multiple fluorescent molecules in a multi-focus confocal setup, enabling 3D high-speed tracking below the diffraction limit.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

The paper shows Belgian endive root extracts promote shoot and root growth in Arabidopsis and Plectranthus, with water-soluble sugars and malate as key bioactive compounds.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

This paper introduces microbowls with controlled concavity to improve the accuracy and sensitivity of microscale mass spectrometry by concentrating analytes.