L. Xu

The paper shows that CD45+CD71+ erythroid cells in COVID-19 patients express SARS-CoV-2 entry factors and are immunosuppressive, suggesting their involvement in hypoxia and erythropoiesis disruption.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

This paper develops an in vitro assay to evaluate nucleotide analogs against SARS-CoV-2 RdRp, showing varying incorporation efficiencies and chain termination effects.

The paper investigates the evolution of a sex megachromosome in cichlid fish, finding it consists of three distinct regions and contains unique genomic features.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

This study characterizes how human serum affects the lipid composition and cell envelope structure of Staphylococcus aureus, showing serum lipids associate with the cell surface but are not fully integrated into the membrane.

The paper characterizes antibiotic resistance genes and opportunistic pathogens in a hospital environment using genomic sequencing and identifies multidrug-resistant strains persisting for over 8 years.

This study shows that human limbal niche cells in 3D Matrigel can induce dedifferentiation of mature corneal epithelial cells into a progenitor state.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study shows that combining a BET PROTAC (ARV 825) with a CDK9 inhibitor (AZD 4573) effectively reduces multiple myeloma cell viability and induces apoptosis.

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

This study shows remdesivir reduces renal fibrosis in obstructed kidneys without affecting renal or liver function.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study analyzes over 28,000 PilZ domain proteins using sequence similarity networking to uncover sequence-function relationships and functional diversification across the superfamily.

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

This study examines how social support moderates the relationship between role conflicts and job satisfaction among nurses with multiple roles in China.

This study identifies an unconventional voltage-sensing mechanism in TRPV1 channels where outer pore acidic residues, not the S4 segment, mediate voltage sensitivity and activation.

This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.

The paper identifies a novel rpoB mutation in MRSA associated with tedizolid resistance and reports cross-resistance to other antibiotics.

This study shows gut bacteria enhance dsRNA-induced mortality in leaf beetles by accelerating dsRNA degradation and causing microbiota dysbiosis.

This study identifies HDAC6 as a driver of RMS tumor growth, self-renewal, and migration/invasion, with RAC1 as a key mediator, suggesting targeting the HDAC6-RAC1 axis as a therapeutic strategy.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

This study evaluates a novel Brucella multiepitope recombinant protein as a diagnostic antigen for brucellosis, showing strong immunoreactivity and diagnostic accuracy in mice.

This study identifies Sle1 as a key factor in β-lactam resistance in MRSA USA300, showing that high Sle1 levels promote cell separation and reduce oxacillin sensitivity.