R. Chen

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

The paper defines single-cell trajectories and identifies chromatin regulators that establish antiviral CD8 T cell heterogeneity during acute and chronic infections.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

The study finds that women in their fertility phase rate men with high serum testosterone as less attractive, challenging the ovulatory shift hypothesis.

This paper evaluates high-resolution atmospheric and oceanic simulations of the California Current System, showing good agreement with satellite and in situ measurements for physical fields and wind forcing impacts.

This study compares retinal organoid differentiation speed between rhesus macaque and human stem cells, finding NHP-derived organoids develop faster.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

This paper investigates cytostatic hypothermia as a therapeutic approach for glioblastoma, showing it extends survival in rodent models by halting tumor growth without chemical interventions.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study characterizes the airway bacterial and fungal microbiome in COPD patients and healthy controls, finding altered microbial diversity and interactions associated with disease severity.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

The paper validates a 48-gene NGS panel for detecting actionable genomic mutations in myeloid neoplasms, showing high sensitivity and specificity.

This study shows marine reserves can improve fisheries yields and bycatch persistence depending on species' life histories, using theoretical models with age structure.

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

The paper examines how fishing near marine reserves can enhance yields by considering individual loss at boundaries and movement preferences.

This study characterizes ocular biometrics and retinal function in rhesus macaques, finding similarities to human eyes, particularly in macular structure and cone photoreceptor function.

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

This study isolates and profiles human monoclonal antibodies against SARS-CoV-2 spike protein, identifying neutralizing antibodies targeting the receptor-binding domain.

This study shows focused ultrasound activates ER-localized PANX1 in invasive cancer cells, triggering calcium release and cytokine release, suggesting a new adjuvant therapy for cancer immunotherapy.

This study characterizes an obese ZSF1 rat model of cardiometabolic syndrome and shows that GDF15 treatment reduces metabolic markers and improves cardiac function.