X. Li

This study identifies curved adhesions as a new type of integrin-mediated adhesion that forms in soft matrices and is crucial for 3D cell migration.

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

This study identifies FAN, a homolog of AATF/Che-1 in Arabidopsis, as essential for genome stability through the ATR-induced DNA damage response pathway.

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

This study identifies a conserved MAPK cascade in S. sclerotiorum essential for growth, development, and virulence, and demonstrates its targeting by HIGS reduces pathogen virulence.

This study uses bulk RNA-sequencing to compare gene expression in small airway cells from IPF and post-COVID fibrosis patients, revealing disease-specific genetic signatures and differential responses to TGF-β1 treatment.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study identifies anti-fungal terpenoids from switchgrass ecotypes and shows their differential effects on fungal isolates, supporting their role in microbiome composition.

This paper determines the structure of the talin-KANK1 complex, revealing how KANK1 binds talin and its localization in focal adhesions is regulated by actomyosin tension.

This study identifies the ATM-E6AP-MASTL axis as a timer-like mechanism that ensures the transient DNA damage checkpoint by promoting cell cycle recovery.

This study finds that antibiotic resistance gene co-localization is common in infants' gut microbiomes and linked to immature microbial composition.

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

This study reveals that CD69 acts as a transmembrane protein agonist of S1PR1, promoting Gi-dependent internalization and inhibiting lymphocyte egress.

This study identifies distinct transcriptomic features in satellite cells of extraocular muscles that preserve neuromuscular junctions in ALS mice, suggesting potential therapeutic strategies.

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

This study redirects an exocytic Rab, Sec4, to endocytic vesicles and shows that cells tolerate this misdirection without significant growth defects.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

The paper identifies four WRKY transcription factors upregulated by sugar via a superoxide signaling pathway dependent on hexokinase 1, suggesting a role in plant growth regulation.

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

This study shows that Wg signaling reduces lipid accumulation in Drosophila adipocytes by repressing lipogenesis and fatty acid β-oxidation while promoting lipolysis.

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.