Y. Chen

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

Effects of different feeding methods on serum biochemical indexes, metabolic indexes, immune indexes, and intestinal microorganisms of Nanjiang yellow goats

This study examines how different feeding methods affect serum biochemical, immune, and metabolic indicators and intestinal microbiota in Nanjiang Yellow goats, finding significant differences in metabolites, immune factors, and microbial composition.

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

This study defines the substrate recognition mechanism of Doa10 using structural and functional analyses in yeast, revealing a lateral tunnel and fence-like domains that facilitate substrate access.

Development of a 3D vascular network visualization platform for one-dimensional hemodynamic simulation

This paper develops a 3D vascular network visualization platform for 1D-0D hemodynamic simulations, demonstrating its use in surgical planning and complication prevention.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

A split crRNA with CRISPR-Cas12a enables highly sensitive, selective, and multiplexed detection of RNA and DNA

This paper develops a split CRISPR-Cas12a system for sensitive, selective, and multiplexed detection of RNA and DNA without reverse transcription, achieving low detection limits and improved specificity.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

Robust trigger wave speed in Xenopus cytoplasmic extracts

The paper investigates trigger wave speed robustness in Xenopus extracts, finding it invariant despite cytoplasmic concentration changes and proposing a model explaining this behavior.

Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery

This study finds that neutrophil extracellular traps (NETs) formation is linked to postoperative complications in neonates and infants after congenital cardiac surgery.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

High-resolution bulked segregant analysis enables candidate gene identification for bacterial wilt resistance in Italian ryegrass

This study uses bulked segregant analysis with whole-genome sequencing to identify a 300 kb region associated with bacterial wilt resistance in Italian ryegrass, revealing candidate resistance genes.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

This paper introduces a trizonal model to predict cancer cell shape transitions under ECM stiffening, revealing three motility zones and their implications for invasion.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to Plasmodium falciparum

The paper examines spatial transcriptomic and proteomic profiles of Hofbauer cells in placentas with and without past Plasmodium falciparum infection, finding no significant differences in HBC features but reduced fetal vessel development in infected placentas.

Visualizing tomato spotted wilt virus protein localization: Cross-kingdom comparisons of protein-protein interactions.

This study examines TSWV protein localization and interactions in plant and insect cells, revealing distinct patterns and interaction networks across species.

RAD-seq unravels local adaptation along a latitudinal gradient for the wild rice Zizania latifolia

This study uses RAD-seq to analyze genetic adaptation in Zizania latifolia across China's eco-geographical regions, finding environmental factors strongly influence genetic structure and local adaptation.

Expanding the GPCR-RAMP interactome

The paper identifies 122 GPCRs interacting with RAMPs using a DuET library and SBA assay, expanding the GPCR-RAMP interactome to inform therapeutic design.

Engineering a genetic system for female-biased, genetically unmodified progeny in mice without affecting litter size

The paper describes a genetic system in mice that produces predominantly female offspring without affecting litter size or introducing genetic modifications into the offspring.

Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer

This study identifies Med4 as a regulator of metastatic dormancy in breast cancer, showing its role in maintaining chromatin structure and suppressing enhancer activation.

An automated archival single-nucleus total RNA sequencing platform mapping integrative and retrospective cell atlas of gliomas

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

Guild-Level Gut Microbial Alterations Associate with Non-hepatitis Virus related Hepatocellular Carcinoma

This study identifies gut microbial alterations associated with non-hepatitis virus related hepatocellular carcinoma using guild-based analysis of microbiome data.

Nonribosomal peptide synthetases require dynamic interaction between modular domains

This study investigates the dynamic interaction between the C and A domains in NRPS modules, revealing the role of the RXGR motif in adenylation activity and its prevalence across different NRPSs.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.