Y. Xu

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

KaScape quantitatively characterizes TF-DNA binding affinity across all possible sequences using next-generation sequencing and provides a tool to visualize the affinity landscape.

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

The paper constructs a Citrullus super-pangenome using genomic data from 547 watermelon accessions to uncover gene variations and insights into watermelon evolution and domestication.

This study shows that reduced systemic ketogenesis in fasted mice enhances erythroid maturation by boosting fatty acid synthesis and mevalonate pathway with decreased histone acetylation.

This study determines the structure of the CD93-IGFBP7 complex and shows its role in endothelial cell angiogenesis and tumor microenvironment.

This study develops a single molecule imaging method to analyze molecular motion in biological condensates, revealing distinct motion behaviors compared to dilute solutions.

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

This study analyzes the evolutionary patterns of regulatory and coding sequences in opium poppy following whole-genome duplication, showing rapid regulatory element evolution contributes to new phenotypes.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

The paper investigates synthetic lethality in Mycobacterium tuberculosis by showing that simultaneous inactivation of Ndh-1 and Ndh-2 NADH dehydrogenases leads to bacterial death due to impaired NADH oxidation.

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This study examines how alertness affects perceptual detection and discrimination across four experiments, finding reduced sensitivity and precision in discrimination tasks with lower alertness.

The paper develops a two-fluid model to explain cytoplasmic flows and nuclear positioning in early Drosophila embryos, revealing new insights into flow dynamics and their functional roles.

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study identifies a conserved MAPK cascade in S. sclerotiorum essential for growth, development, and virulence, and demonstrates its targeting by HIGS reduces pathogen virulence.

This study identifies a cataract-causing mutation in CRYβB1 that leads to C-terminal truncation, increased proteolysis, and higher-order oligomerization, contributing to lens opacity.

This study shows that SGG UCN34 promotes colon cancer by activating multiple cancer-related signaling pathways through proteomic and phosphoproteomic analyses in mice and human tumors.

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

This study shows that aminobisphosphonates reactivate latent HIV-1 in ART-suppressed individuals and activate immune effector cells, but do not significantly reduce the viral reservoir.

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

The paper investigates how protein conformational heterogeneity contributes to NMR lineshape broadening at cryogenic temperatures by analyzing backbone torsion angles in E. coli DHFR.

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.