Craig William Ritchie

Path integration selectively predicts midlife risk of Alzheimer's disease

The paper shows that midlife path integration impairments predict Alzheimer's disease risk, independent of other cognitive tests.

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

The paper identifies genetic and epigenetic factors influencing plasma protein levels linked to Alzheimer's disease, finding novel associations with TREM2 and TBCA.

Association between plasma phospho-tau181 and cognitive change from age 73 to 82: Lothian Birth Cohort 1936

This study shows that higher plasma phospho-tau181 levels and their increase over time predict faster cognitive decline in older adults and are present in brain synapses.

The European Prevention of Alzheimer's Dementia (EPAD) MRI Dataset and Processing Workflow

The paper describes an MRI dataset and processing pipeline for the EPAD study, identifying quality control features and image-derived phenotypes related to aging and dementia.

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

This study shows that DNAm GrimAge predicts disease incidence and prevalence better than other epigenetic clocks in a large cohort.

The Dementias Platform UK (DPUK) Data Portal

The DPUK Data Portal provides secure access to cohort data for dementia research, supporting multi-modal analyses and collaborations across multiple institutions.

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

This study identifies genetic and epigenetic factors associated with inflammatory protein levels in older adults using GWAS and EWAS with a Bayesian framework.

An epigenetic predictor of death captures multi-modal measures of brain health

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

This study identifies genetic and epigenetic factors associated with neurological protein levels in the Lothian Birth Cohort 1936, revealing potential causal links to neurological diseases.

GWAS on family history of Alzheimer’s disease

This study identifies six new Alzheimer's disease-associated loci using GWAS on family history data from UK Biobank and consortium data, with potential implications for precision medicine.