Xenopus

This study presents cryo-EM structures of pannexin 1 from Xenopus tropicalis and Homo sapiens, revealing its heptameric architecture and molecular sieve mechanism for ATP release.

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

The paper identifies SNX9 as an endogenous component of filopodia and shows its role in filopodia biogenesis through antibody-based screening.

The paper creates a single-chain H2A/H2B dimer and determines its structure, showing it resembles nucleosomal H2A/H2B, providing a tool for studying H2A/H2B-interacting proteins.

This study sequenced and analyzed the transcriptome of Rana chensinensis to identify genes associated with polyunsaturated fatty acid synthesis.

This study shows that early-life social relationships in barnacle geese persist into adulthood, with seasonal variations and male aggression influencing association persistence.

The paper develops a TEVC/dye uptake assay to study molecular transport through CALHM1 and connexin channels, revealing saturable kinetics and voltage-dependent behavior.

The paper examines how flight-related metabolic demands and environmental factors influence molecular evolutionary rates in Furnariidae birds, finding associations between flight traits and mutation rates, and interactions between temperature and UV radiation with selection pressures.

This study uses single-cell RNA sequencing to identify an endosymbiotic cell type in a soft coral and reveals its lineage dynamics during algal uptake and maintenance.

This study shows that cytosolic domain mutations in GIRK4 (KCNJ5) cause loss-of-function rather than gain-of-function, challenging the existing mechanism of hyperaldosteronism.

This study compares pesticide toxicity between fish and larval amphibians, finding strong correlations in sensitivity with only one chemical showing significantly greater frog sensitivity.

This study shows TMTC3 enables O-mannosylation of E-cadherin, affecting cell adhesion and gastrulation, and links TMTC3 mutations to Cobblestone lissencephaly.

This study shows that cohesin and condensin extrude distinct types of loops in interphase and metaphase, respectively, revealing cell-cycle dependent loop extrusion dynamics.

This study shows that alternative splicing of FXR1 regulates its function in muscle development by controlling RNA-dependent condensates and disease-related mis-splicing.

The paper identifies Metaxin 3 as a conserved vertebrate protein with homology to mitochondrial import proteins and GSTs, showing distinct sequence identities and gene adjacency patterns.

The paper identifies PP2A-B55δ as the phosphatase that dephosphorylates Arpp19 at S109, counteracting PKA to release oocytes from meiotic prophase.

The paper uses single-molecule imaging in Xenopus laevis egg extracts to show that most parental histones are evicted during DNA replication, with histone recycling and nucleosome sliding occurring less frequently.

This study investigates how R-roscovitine inhibits hERG channels by analyzing mutations and IC50 values, suggesting some residues are critical while others are not, with implications for drug screening and CiPA guidelines.

This study identifies FACT as a factor that influences Cas9 turnover and genome editing efficiency in human cells.

The paper identifies a 24-amino acid segment in the 5-HT3A intracellular domain that mediates its interaction with the chaperone protein RIC-3.

This paper shows bupropion inhibits 5-HT3AB receptors at clinically relevant concentrations, with stronger effects on heteromeric than homomeric receptors.

This study reconstitutes branching microtubule nucleation using purified Xenopus proteins, identifying augmin and TPX2 as essential factors that guide gamma-TuRC to nucleate branched microtubules.

The paper develops an optimized transport assay to identify GA transporters among NPF proteins and identifies key residues determining substrate specificity.

The paper shows RanGTP creates an effector gradient of XCTK2 and importin α/β that regulates spindle microtubule cross-linking by modulating XCTK2 activity.

The paper identifies xlAZIN2/xlODC2 in Xenopus laevis as a lysine decarboxylase, distinct from mammalian AZIN2, and shows its resistance to proteasomal degradation.

This study shows maltol induces pigment aggregation in Xenopus laevis melanophores in a dose-dependent manner, similar to melatonin, but without affecting key regulatory mRNA expressions.

The paper studies branched microtubule network formation in Xenopus egg extracts, showing that TPX2, augmin, and γ-TuRC regulate nucleation through a sequential reaction pathway.

The paper shows that Xenacoelomorpha and Cnidaria excrete toxins across digestive tissues, suggesting this was the ancestral excretory mode before specialized organs evolved.

This study uses CRISPR/Cas9 in Xenopus tropicalis to show that RBL1/p107 compensates for RB1 loss in driving specific cancers like SC-PaNEC and retinoblastoma.