Xenopus

The paper identifies acetylcholine as a key mediator of hatching enzyme release in red-eyed treefrog embryos, revealing conserved neural mechanisms across amphibians.

The paper examines life history traits across four clades of the chiral livebearer fish Xenophallus umbratilis to assess conservation needs and adaptive evolution.

This study shows that RPA prevents unregulated priming and Rad51 loading on ssDNA in Xenopus egg extracts, maintaining genome stability.

This study investigates how RGA-3/4 regulates F-actin structure in vivo and in vitro, showing it directly binds and bundles F-actin, providing insights into its role in cortical excitability and cytokinesis.

The paper shows that TOPBP1-dependent DNA damage processing leads to CENP-A loss and centromere destabilization in inviable Xenopus hybrids.

The paper shows that proteins in cell-like environments reduce RNA folding stability by passively suppressing base pairing, altering RNA structure predictions.

This study shows HMCES-DPC formation increases DNA template flexibility, enabling slippage and mutagenic bypass of AP sites during replication.

The paper shows PAXX and XLF have sequential roles in stabilizing and maturing the NHEJ synaptic complex through distinct interactions.

The paper shows that cytoplasm in early embryos behaves as a locally switchable active material, enabling long-range transport of components during cleavage.

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

This study shows PAK4 and Afadin cooperate to maintain epithelial integrity by promoting vertex remodeling, with PAK4 inhibition disrupting junctional continuity and barrier function.

This paper introduces a CE-ESI-MS workflow that enables simultaneous proteome and metabolome analysis in a single run, preserving depth and resolving cell-type differences in Xenopus blastomeres.

This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.

This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.

This study investigates how actin monomers affect XCAP1's interaction with actin filaments using high-speed atomic force microscopy, revealing differences in binding dynamics and preferences.

This study identifies and functionally characterizes CXCL17 orthologs in amphibians, revealing conserved mechanisms of GPR25 receptor activation.

This study establishes an in vitro FRET-based assay to monitor cholesterolysis activity of vertebrate SHhC domains, revealing substrate specificity and identifying a conserved aspartate residue critical for activity.

This study compares reproductive strategies between two swordtail fish species, finding that X. malinche produces larger, more resilient offspring through extended post-fertilization nutrient provisioning.

This study identifies lipid mono-unsaturation as a mechanism for cold tolerance in frogs and shows its potential to improve tissue viability during hypothermic storage.

This paper identifies how Bora activates Aurora A and Plk1 kinases during mitosis through structural and biochemical analysis.

The paper examines replicate avian hybrid zones to assess the repeatability and progression of genetic and trait introgression over time.

The paper identifies two proteins, Ccdc78 and Ccdc33, at the distal tip of vertebrate motile cilia, showing they are essential for cilia organization, length regulation, and function.

This study introduces an in-cell proteomics method to analyze early Xenopus tropicalis embryos, revealing detailed spatiotemporal protein dynamics across cleavage stages.

This study identifies Mena as a key mediator of Wnt signalosome endocytosis, showing it promotes Wnt signaling by binding LRP5/6 and facilitating receptor uptake.

This study links irregular iris pigmentation in Northern Gannets to past exposure to HPAIV H5N1, showing it can serve as a non-invasive marker for disease surveillance.

This paper identifies Homer and MUPP1/PatJ as regulators of calcium-dependent actin dynamics at the apical junctional complex, essential for epithelial mechanosensation and wound healing.

This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

This study shows Diversin localizes to cell junctions during Xenopus morphogenesis and responds to mechanical forces, influencing planar cell polarity and tissue closure.