spatial domain detection

Transient cortical activity modulates somatosensory gating during postural control

This study shows that somatosensory responses during postural control are influenced by prestimulus cortical activity and connectivity, with specific beta-band features correlating with changes in evoked potentials.

Coordinated spatial organization of basal ganglia structures revealed by dopamine subtype projectome mapping

The paper maps dopamine subtype projections in the basal ganglia to reveal spatially distinct domains and their correlation with striatal neuron subclasses and cortical inputs.

Multi-scale microenvironment covariance for unsupervised spatial domain identification

The paper introduces CoSMIM, a method for spatial domain identification that uses multi-scale gene-gene covariance matrices, achieving top performance on multiple benchmark datasets.

The U6 snRNA capping enzyme Amus/MePCE is required for the stability of U6atac and the processing of introns with features of both major and minor classes

The paper identifies a role for Amus/MePCE in stabilizing U6atac and shows that some minor introns require both major and minor splicing pathways for processing.

Multi-scale histology reveals localized ageing signatures in normal human colon

This paper uses multi-scale histology to identify localized age-related changes in normal human colon tissue using H&E images and machine learning.

Artificial hibernation uncovers distinct interaction dynamics in functional and pathological state change

This study uses artificial hibernation to show that neural network reorganization can occur without functional impairment and may prevent pathological state progression.

Dissecting cellular and molecular networks of aging and senescence in the human hippocampus

This study identifies spatially resolved aging and senescence signatures in the human hippocampus using multi-omics approaches, revealing cell-type and sex-specific gene expression changes.

Early development of cerebellar functional connectivity

The paper maps cerebellar functional connectivity in neonates, identifying intrinsic networks and cerebro-cerebellar clusters that mature with age, suggesting early foundations of adult organization.

Early hematopoietic fate decisions are independent of bone marrow niche

This study shows that early hematopoietic fate decisions are not strongly influenced by bone marrow niche identity, as fate-shaping signals are redundantly provided across niches.

Spatial multi-omics implicates vascular adipocytes proximal to tertiary lymphoid structures in human aortic aneurysm and B-cell autoreactivity.

This study uses spatial multi-omics to show that vascular adipocytes near tertiary lymphoid structures in human aortic aneurysms contribute to B-cell autoreactivity and inflammation.

Mapping the topographic organization of the human zona incerta using diffusion MRI

This study maps the topographic organization of the human zona incerta using diffusion MRI and connectivity analysis, revealing gradients and clusters linked to specific cortical regions and functions.

Spatial segregation and multi-scale space-use adjustments to socio-ecological variables in western gorillas

This study examines spatial segregation and multi-scale space-use adjustments in western gorillas, finding that home range shifts and daily movements are influenced by socio-ecological factors rather than territorial behavior.

Low-order MLKL oligomers induce irregular membrane defects in necroptosis

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target

This study identifies STING as a therapeutic target for Kawasaki disease by analyzing spatial immune architecture in cardiac inflammation.

Development of Neonatal Functional Brain Network Organisation and Its Association with Childhood Neurodevelopmental Outcomes

This study examines neonatal functional brain network organisation using fMRI and links it to childhood neurodevelopmental outcomes, finding associations with later difficulties in 4-6 year olds.

Microscale Characterization of Undecalcified Bone Tissue Using Correlative Atomic Force Microscopy and Histology

This study develops a method combining AFM and histology to analyze undecalcified bone tissue, revealing age-related changes in structure and stiffness in mice.

MorphoDeep enables fast 3D cell instance segmentation by learning cell interfaces and junctions

MorphoDeep improves 3D cell segmentation by learning cell interfaces and junctions, achieving higher accuracy and speed than existing methods.

The hepatic mitochondrial landscape

This study maps mitochondrial gene expression across the liver lobule in mice and humans, revealing spatial and temporal heterogeneity in mitochondrial function and structure.

KRT7CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.

Distinct spatial organization of human hippocampal perfusion and microvascular pulsatility across age

The paper maps human hippocampal perfusion and microvascular pulsatility across age using MRI and integrates these with histological and transcriptomic data, revealing distinct spatial organization and age-related differences.

The Muskox Way: Humans, plants and animals in northeast Greenland through the Holocene

The paper uses sedimentary ancient DNA to analyze the timing of plant and animal arrivals in northeast Greenland, showing muskox arrived before humans and environmental changes coincided with cultural periods.

Epigenomic heterogeneity and spatial organization during human reprogramming

This study examines epigenomic and spatial changes during human reprogramming, finding distinct molecular and spatial patterns in productive versus unsuccessful trajectories.

Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

This study shows that stable graded representations of threat value persist in the prelimbic cortex despite ensemble turnover during fear learning.

From Coral Color to Tissue Heating: How Host Pigments Redirect Light Within the Tissue

The paper models how coral host pigments affect light propagation and tissue heating, showing distinct roles of chromoproteins and fluorescent proteins in energy distribution and heat generation.

Social Approach Dynamics in Freely-Moving Rat Dyads are Not Impacted by Lesions to the Retrosplenial Cortex

This study shows that lesions to the retrosplenial cortex in rats do not significantly affect social approach dynamics during interactions with a social stimulus.

Temporal instability weakens entorhinal grid-like coding in older adults

This study shows that unstable hexadirectional signals in the entorhinal cortex of older adults correlate with poorer memory and reduced signal strength, suggesting grid-like coding instability rather than absence.

Abnormal nuclear organization impairs adipogenic lineage commitment and terminal maturation in Hutchinson-Gilford progeria syndrome (HGPS)

This study shows that HGPS disrupts adipogenic lineage maturation through chromatin reorganization defects, despite normal lineage commitment rates.

Longitudinal diffusion tensor imaging identifies coordinated white matter remodeling during cocaine self-administration in mice

Heterochronic Uncoupling of Brain and Face Morphogenesis Drives Premature Fusion in Ciliary Transition Zone Mutants

The paper shows that reduced brain growth in ciliary transition zone mutants causes premature facial fusion by mechanically forcing facial prominences into convergence.

Expanding Hippocampal Ensembles through LINE-1 RNA Downregulation Enhances Cognition

This study shows that reducing LINE-1 RNA in hippocampal neurons increases their firing capacity and expands neuronal ensembles, improving spatial memory but reducing pattern separation.