T-cell and B-cell Immunology

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

This study shows that DNA methylation via UHRF1 is essential for iTregs to promote lung recovery after viral pneumonia.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

This study uses Monte Carlo simulations to show that TCR clustering and NP geometry affect the sensitivity-specificity trade-off in T cell responses to pMHC-coated nanoparticles.

This study compares memory CD8 T cells generated from tumor rejection and acute viral infection, finding that tumor-induced cells show persistent functional defects similar to exhaustion.

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

SeQuoIA is a single-cell BCR sequencing pipeline that tracks selection mechanisms in germinal centres by inferring BCR-driven selection pressure from somatic mutation patterns.

This study shows that exhausted T cells can form functional memory T cells after antigen clearance, and checkpoint blockade expands these memory clones.

The paper identifies a Dapl1+ subset of naive CD8 T cells that are pre-programmed to differentiate into memory-like T cells.

This study shows that recent thymic emigrants are preferentially recruited into the memory pool during persistent CMV infection, while mature CD8+ T cells contribute little.

This study shows overexpressing GITRL on BDL B cells increases Treg numbers and reduces EAE severity in mice, suggesting a therapeutic strategy for autoimmunity.

This study compares transcriptional profiles of memory T cells in infants and adults to identify age-specific regulatory mechanisms.

The paper identifies lytic IFNγ stored in granzyme B-containing cytotoxic granules and co-secreted with GzmB by effector CD8⁺ T cells during immunological synapse formation.

This study identifies unconventionally primed TFH1 cells as essential for generating IgA+ long-lived plasma cells during mucosal viral infections.

This study shows that persistent antigen is necessary for maintaining Leishmania-specific memory CD4+ T cells and long-term immunity.

This study identifies miR-130b and its GUGCA seed motif as regulators of B cell tolerance, revealing ERalpha as a female-specific checkpoint that influences autoimmunity.

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.

This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.

The paper shows LAIR1 expression decreases during B cell differentiation and is regulated by the IL-21/STAT3 pathway, with implications for B cell autoreactivity and systemic lupus erythematosus.

The paper identifies a cDC1-CD8/NKT regulatory circuit that limits plasma cell accumulation after injury, which is disrupted by microplastic contamination.

This study identifies NFATc1 as a suppressor of IL-15-induced NK-like activation in human memory CD8+ T cells via the Ca2+-calcineurin pathway and defines a gene signature associated with bystander activation.

This study shows that human T follicular helper cells differentiate in vitro through STAT3 and SMAD cytokine cooperation, but IL-2 inhibits this process.

This study develops an in vitro lymph node microphysiological system to model early T cell-B cell interactions and antibody responses using primary human lymphocytes.

This paper measures 3D affinities of the OT-I TCR to 19 pMHC complexes and finds they strongly correlate with 2D membrane affinities, revealing imperfect antigen discrimination.

This study shows DDX1 promotes B-cell proliferation in germinal centres by enhancing mRNA translation through tRNA ligase activity, crucial for affinity maturation.