T-cell and B-cell Immunology

This study identifies the MLL1-MENIN complex as a regulator of CD8 T cell memory through the TOX-BTLA-TCF1 axis, independent of its methyltransferase activity.

This study identifies tissue-specific signaling pathways critical for memory T cell persistence in spleen and bone marrow.

This study shows that early glycolysis inhibition enhances Tfh cell differentiation but impairs their function, revealing a glycolysis-fatty acid metabolic axis that controls Tfh function.

The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.

This study identifies T-bet expressing B cells as critical for mucosal immunity and protection against norovirus infection through IgG and IgA responses.

This study identifies Fnip1 as a regulator of B cell development by modulating BCR signaling and metabolic pathways, leading to impaired differentiation and accumulation of specific B cell subsets.

The paper introduces QuEST immunofluorescence microscopy to quantify TCR signalosome stoichiometries in human T cells, revealing a 1:1 ZAP-70:TCR ratio and CD28 recruitment independent of CD80/CD86.

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

This study shows coordinated IL-2 and TGF-β3 signaling expands and activates regulatory T cells, reduces autoimmune responses, and promotes immune tolerance.

The paper introduces immunoPETE, a DNA-based platform for profiling B and T cell receptors, and demonstrates its performance in immune repertoire analysis and clinical applications.

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

This study examines how MAIT cells respond to S. aureus and how their sensitivity to the toxin HlgAB varies by tissue location and activation state.

The paper shows that low DMSO concentrations skew T cell differentiation towards a memory phenotype during in vitro expansion.

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

This study shows IL-2 is needed for GATA3 upregulation in TH2 cells, while IL-4 promotes their proliferation and effector function in vivo.

This study shows that Cbfb2 gene dosage regulates the developmental potential of hematopoietic progenitors, enabling fetal-like lymphoid lineage generation in adults.

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

This paper develops a multi-scale mathematical model to integrate BCR/TCR repertoire diversity with immune kinetics, revealing mechanisms of immune imprinting and chronic infection control.

This study identifies cDC1 and cDC2 as essential for TGF-β activation and pTreg induction in the gut, maintaining immune tolerance.

The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.

This study identifies tissue-specific features of T follicular cytotoxic cells in T. cruzi infection, showing distinct metabolic and functional states in spleen and lymph nodes.

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

The study shows that the secondary B cell response magnitude is driven by antibody feedback inhibition, not the number of memory B cells before vaccination.

The paper investigates immediate transcriptional changes in T cells upon direct contact with cancer cells using single-cell transcriptomics and identifies distinct T cell subsets associated with reduced TCR diversity.