Tuberculosis Research and Epidemiology

The paper simulates TB antibiotic regimens in a computational model to show rankings are influenced by spatial scale, detection limit, and initial bacterial burden.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

This study shows that mucosal BCG vaccination induces lung CD8+ TRM cells via TGF-β activation by airway epithelial progenitors, linking tissue repair to immune memory.

This study shows that cholesterol metabolism and potassium homeostasis are interconnected in Mycobacterium tuberculosis, with cholesterol modulating potassium transport and affecting bacterial growth.

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.

This study identifies Mtb genes essential for survival in vaccinated and previously infected hosts using TnSeq, revealing differences in genetic requirements across immunization strategies.

This study investigates two mutations in M. tuberculosis B0/W148 clone, finding they do not impair growth or virulence but alter transcriptional profiles.

This study identifies MgdE, a mycobacterial nucleomodulin, as a protein that targets the host COMPASS complex to suppress pro-inflammatory gene transcription and enhance bacterial survival.

This study analyzes the pangenome and population genetics of Mycobacterium tuberculosis to understand its genetic diversity, evolutionary patterns, and their implications for epidemiology and pathogenesis.

This study identifies TDM's mechanism of inhibiting phagosome maturation by interacting with SNARE proteins, promoting M. tuberculosis growth.

This study uses single-cell imaging and a deep neural network to rapidly assess drug susceptibility in Mycobacterium tuberculosis variant bovis BCG, achieving results in under 12 hours.

This study shows that autologous serum improves in vitro granuloma formation and alters immune responses compared to commercial serum in a Mycobacterium tuberculosis infection model.

The paper identifies 18 novel SNPs in DNA repair genes linked to drug resistance in Mtb using genome-wide analysis of 53,589 whole-genomes.

This study presents cryo-EM structures of AftB from Mycobacterium chubuense, revealing its architecture and mechanism for terminal arabinosylation in mycobacterial cell wall biosynthesis.

This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.

This study shows that the direct sulfhydrylation pathway in Mycobacterium tuberculosis is essential for growth at low pH and modulates BDQ sensitivity.

This study characterizes the proteomic changes in Mycobacterium tuberculosis under carbon starvation, revealing extensive reprogramming and retention of cell wall biosynthesis enzymes.

This study identifies MHC class I restricted peptides from M. tuberculosis clinical isolates that induce immunogenic responses in PBMCs, suggesting their potential as vaccine candidates.

This study identifies a novel L-leucine uptake mechanism in Mtb using a chemical genomic approach, revealing a target involved in cell-wall lipid biosynthesis and demonstrating in vivo efficacy of semapimod.

The paper shows that MBX-4132, a trans-translation inhibitor, kills Mycobacterium tuberculosis and non-tuberculous mycobacteria, with zinc enhancing its activity and iron reducing it.

This study investigates selamectin resistance in Mycobacterium smegmatis and finds that resistance requires specific mutations and intact cell envelope integrity.

This study shows that removing B cell-derived IL-10 increases resistance to tuberculosis in mice, with stronger effects in males.

The paper predicts Mtb fitness using a transcription factor activity-based machine learning model trained on RNA-seq data and regulatory network analysis.

Demixer identifies strain proportions and identities in mixed infection samples using a probabilistic generative model, achieving high accuracy in both synthetic and real-world datasets.

The paper evaluates the effectiveness of standard TB drugs in mice, showing rifampin's critical role in killing bacteria and preventing resistance.

This paper uses 3D imaging to show that M. tuberculosis ESX-1 affects granuloma architecture in infected mice.

This study integrates transcriptomic, genomic, and GWAS data to identify genes and eQTLs associated with the PB transcriptome response to M. bovis infection in cattle.

This study shows that targeting CCRL2 with an antibody-drug conjugate improves TB treatment in mice by reducing inflammation and enhancing immune responses.

The paper integrates multi-omic data to identify latent factors associated with resistance to TB conversion, revealing pathways related to multicellular structure and cell-cell interactions.

This study investigates CD4 T cell dysfunction in chronic tuberculosis and links it to bacterial recrudescence in mice.