MicroRNA in disease regulation

Human.miRFFL.DB- A curated resource for human miRNA coregulatory networks and associated regulatory-circuits

Human.miRFFL.DB curates human miRNA:TF:TG coregulatory networks and their regulatory-circuits, providing interactive visualization and analysis tools for studying gene regulation.

Let-7i-5p regulation of cell morphology and migration through distinct signaling pathways in normal and pathogenic fibroblasts from urethra

This study identifies let-7i-5p's role in regulating cell morphology and migration through distinct signaling pathways in normal and pathogenic fibroblasts from urethra.

ERH as a component of the Microprocessor facilitates the maturation of suboptimal microRNAs

This study identifies ERH as a new component of the Microprocessor complex that enhances processing of suboptimal pri-miRNAs in polycistronic clusters.

Sensitivity of Gene Sets to miRNA Regulation: A Cell-Based Probabilistic Approach

The paper uses a stochastic framework to analyze gene sensitivity to miRNA regulation in HeLa cells, identifying gene sets particularly sensitive to miRNA overexpression.

GENOMIC COMPETITION FOR NOISE REDUCTION SHAPED EVOLUTIONARY LANDSCAPE OF MIR-4673

The paper investigates the evolutionary origin of miRNA-4673 and its role in reducing transcriptional noise through interactions with cis-regulatory elements.

A consistent evaluation of miRNA-disease association prediction models

The paper evaluates miRNA-disease association prediction models, identifies data leakage issues, and improves performance on two datasets.

NF90 Modulates Processing of a Subset of Human Pri-miRNAs

The paper shows NF90 modulates processing of a subset of human pri-miRNAs by binding to stable intronic structures, increasing mature miRNA abundance when NF90 is lost.

miRSwitch: Detecting microRNA arm shift and switch events

miRSwitch detects microRNA arm shifts and switches using sncRNA-seq data, providing analysis tools and a reference map of arm shift frequencies across tissues and species.

The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer

The paper identifies two novel miRNAs, hsa-miR-nov3 and hsa-miR-nov7, overexpressed in breast cancer and correlates their expression with tumor subtypes and patient outcomes.

Role of Differential Expression of miRNAs miR-125a, miR-200a and miR-199a in Metastatic Property of Ovarian Cancer Cell lines and Relationship between miR-199a and its Predicted Target Protein GSK3β

miRViz: a novel webserver application to visualize and interpret microRNA datasets

miRViz is a webserver for visualizing and interpreting miRNA datasets to identify significant differentially expressed miRNAs.

dbMTS: a comprehensive database of putative human microRNA target site SNVs and their functional predictions

dbMTS compiles putative human microRNA target site SNVs with functional annotations to aid in identifying SNVs affecting miRNA targeting.

mir-21 is associated with inactive low molecular weight Argonaute complexes in thyroid cancer cell lines

The paper investigates the distribution of miR-21 between HMW-RISC and LMW-RISC fractions in thyroid cancer cell lines and finds miR-21 is more enriched in LMW-RISC.

Treating the Network: Targeted inhibition of two specific microRNAs in the brainstem prevents the development of hypertension

Blocking two microRNAs in the brainstem prevents hypertension in SHR rats by modulating gene regulatory networks.

Drosha Regulates Oogenesis and microRNAs Germline Autonomously and Non autonomously in C. elegans

The paper identifies Drosha-dependent microRNAs that regulate oocyte development both autonomously and non-autonomously in C. elegans.

Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice

The paper introduces miRAMINT, a method combining feature selection and shape analysis to identify miRNA-mRNA pairs in HD mice, revealing 31 precise regulatory relationships in striatum.

Fe(III) heme sets an activation threshold for processing distinct groups of pri-miRNAs in mammalian cells

The paper investigates how Fe(III) heme availability affects pri-miRNA processing by DGCR8 and identifies a heme affinity threshold for Microprocessor activity.

Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries

The paper presents a method to deplete dominant miRNAs from blood-derived RNA samples, improving detectability of low-abundance miRNAs in small RNA sequencing.

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

The paper identifies brain microRNAs linked to late-life depressive symptoms and shows their association with cognitive decline and dementia risk.

The mirtron miR-1010 functions in concert with its host gene SKIP to maintain synaptic homeostasis

The paper identifies miR-1010 as a mirtron that works with its host gene SKIP to regulate synaptic homeostasis by modulating nAcRβ2 and CaMKII signaling.

Elucidation of novel miRNA candidates and their role in unraveling the pathology of Non-Alcoholic Fatty Liver Disease

The paper identifies miRNAs involved in NAFLD/NASH pathophysiology and suggests their potential as diagnostic markers through in silico and experimental validation.

Complex networks of miRNA-transcription factors mediate gene dosage compensation in aneuploid cancer

The paper identifies miRNA-transcription factor networks that mediate gene dosage compensation in aneuploid cancer cells, showing therapeutic potential through miRNA inhibition.

Improving bioinformatics prediction of microRNA targets by ranks aggregation

The paper introduces miRabel, a tool that aggregates results from three miRNA prediction algorithms to improve target prediction accuracy and consistency.

MicroRNA-184 Is Induced By Store-Operated Calcium Entry And Regulates Early Keratinocyte Differentiation

The paper shows that extracellular calcium induces miR-184 via SOCE in keratinocytes, which promotes differentiation by regulating cyclin E and DNA damage markers.

FilTar: Using RNA-Seq data to improve microRNA target prediction accuracy in animals

FilTar improves miRNA target prediction accuracy in animals by using RNA-Seq data to filter non-expressed transcripts and refine 3UTR annotations.

Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation

The paper shows that post-transcriptional regulation, not transcription, mainly drives variation in mature miRNA expression across tissues and cancers.

Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome

This study identifies miRNA targets using a direct capture method, showing miRNAs regulate thousands of transcripts and reveal pathways involved in cancer and signaling.

MicroRNA miR-100 decreases glioblastoma growth by targeting SMARCA5 and ErbB3 in tumor-initiating cells

A cell-based probabilistic approach unveils the concerted action of miRNAs

The paper uses a probabilistic framework to study miRNA regulation, finding that translation machinery is insensitive to miRNA manipulations across cell types.

Identifying miRNA synergism using multiple-intervention causal inference

The paper introduces miRsyn, a causal inference framework to identify miRNA synergism using observational data, finding that many miRNA pairs with shared targets do not synergize at the expression level.