Gut microbiota and health

Progressive Post-Acute Gut Microbiome Disruption Following SARS-CoV-2 Infection in Mice

This study tracks gut microbiome changes in mice after SARS-CoV-2 infection, showing progressive dysbiosis and functional shifts over time.

Age-Dependent Patterns of Gut Bifidobacterium Microbiome Diversity across child Cohorts in a Multi-Ethnic population, Western China

This study examines age-related changes in gut microbiome diversity among children in a multi-ethnic population in Western China, identifying Bifidobacterium breve as a key species associated with growth and development.

Ultra processed microbiome: Effects of dietary Stable Carbonyl adducts (SCars) on developing microbiota of mice

This study examines how high levels of dietary SCars during puberty affect the gut microbiome of mice, finding reduced diversity and changes in metabolic pathways.

Gut archaea drive human MAIT cell responses

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

Anti-psychotic therapeutics modify gut microbial metabolism and modulate susceptibility to gastrointestinal infection in mice

This study shows antipsychotics alter gut microbiota and metabolome, increasing susceptibility to infection in mice.

Gut bacterial composition and predicted functional profiles associated with depressive symptom burden in Japanese adults recruited independently of depression diagnosis

This study explores associations between depressive symptoms and gut microbiota composition and function in Japanese adults without a depression diagnosis.

Intestinal serotonergic vagal signaling as a mediator of microbiota-induced hypertension

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

This study shows the type VI secretion system (T6SS) in Bacteroides acidifaciens helps maintain its presence in a wild mouse gut microbiome by antagonizing other Bacteroidales, but its effect depends on ecological context.

Post-Weaning Gut Microbiota Colonization Reveals Divergent Recovery of Skeletal Muscle and Peripheral Nerves

This study shows that post-weaning gut microbiota colonization partially restores skeletal muscle but not peripheral nerve abnormalities in germ-free mice.

Sensory variation and behavioural degeneracy: a framework for interpreting heterogeneity in the gut-brain axis

The paper presents a model showing that gut microbiome differences can arise from varied behavioral pathways, challenging the assumption that microbiome states uniquely reflect biological differences.

PAR2 signaling shapes microbial and metabolic remodeling along the gut-lung axis

This study investigates how PAR2 signaling influences microbial and metabolic changes across the gut-lung axis in response to HDM exposure, showing compartment-specific effects and sex-dependent differences.

Long-Read Metagenomic Sequencing Reveals Persistent Gut Microbiome Alterations in Children with Celiac Disease in Remission

Corpusome, a cross-body-site human microbiome corpus for representation learning

The paper introduces Corpusome, a harmonized human microbiome corpus spanning multiple body sites, to improve cross-body-site representation and cross-study generalization in microbiome research.

Solid Foods Drive the Maturation of the Gut Microbiota During Infancy

This study examines how introducing solid foods during infancy affects gut microbiota composition and diversity, showing significant changes in microbial richness and diversity linked to dietary transitions.

Shared species, strains and resistome between humans and pigs: A metagenomic analysis

This study uses metagenomics to analyze microbial and resistome sharing between pigs and farmers, finding shared species and resistome signatures but no evidence of strain or mobile genetic element transmission.

Multi-omic dissection of reversible and persistent molecular alterations in diet-induced obesity

This study identifies reversible and persistent molecular changes in diet-induced obesity using multi-omic analysis, showing that microbial functional profiles drive persistent alterations.

A defined microbial community remodels host metabolism and pathogen resistance in Caenorhabditis elegans

This study shows that a defined microbial community remodels host metabolism and pathogen resistance in C. elegans by altering transcriptional pathways and physiological traits.

Evaluating Few-Shot Meta-Learning using STUNT for Microbiome-Based Disease Classification

This study evaluates STUNT, a meta-learning framework for microbiome-based disease classification, finding that its benefits are limited under data scarcity and diminish with more samples.

Growth capacity and mortality burden shape microbial persistence under osmotic stress in Bacteroides thetaiotaomicron

The paper shows that microbial persistence under osmotic stress in Bacteroides thetaiotaomicron depends on both growth capacity and reduced cell loss.

Over-the-counter fiber supplementation associates with metabolic and microbial shifts in rectal mucosa

This study examines how over-the-counter fiber supplements affect the rectal mucosal environment by altering microbiota, SCFA levels, and host gene expression in patients with benign anorectal disease.

Age-related changes in the gut microbiota of a long-lived seabird suggest divergence from mammalian models

This study examines age-related gut microbiota changes in Atlantic puffins, finding population-level structuring in chicks that disappears in adults, with contrasting patterns compared to mammals.

Seven gut microbiome types across two Japanese cohorts defined by co-abundance-based microbial guilds and associated with host physiology

The paper identifies seven gut microbiome types in Japanese adults using co-abundance-based microbial guilds, linking them to host physiological traits like renal function and inflammation markers.

Integrated gene-catalog and genome-resolved metagenomics reveal taxonomic and metabolic differences in the gut microbiome in irritable bowel syndrome

This study integrates gene-catalog and genome-resolved metagenomics to show taxonomic and metabolic differences in the gut microbiome of IBS patients compared to healthy controls.

Gut Microbiota Signatures of Brain and Peripheral gamma-amino butyric acid (GABA) in Healthy Adult Males

The paper investigates associations between gut microbiota composition, brain and blood GABA levels, and related features in healthy adults.

Hidden palette: Culturing the sauropsid gut microbiome reveals a high prevalence and diversity of bacteria that undergo carotenoid biosynthesis

The paper isolates gut bacteria from wild sauropsids and finds a high prevalence of carotenoid-producing microbes across multiple species.

A configuration-resolved benchmark of differential abundance analysis methods for human gut 16S rRNA microbiome data

The paper benchmarks differential abundance analysis tools for human gut 16S rRNA data across configurations, showing that settings significantly impact performance and must be reported for interpretability.

Short-term oxycodone exposure produces delayed and persistent gut microbiome disruption in mice

This study shows that short-term oxycodone exposure in mice causes delayed and persistent gut microbiome changes that persist for at least 70 days post-treatment.

Metagenome-scale Modeling to Assess Microbiome Metabolic Complementarity for Precision Microbiota Transplantation Therapies

This paper develops a metagenome-scale metabolic model to predict FMT outcomes by assessing donor-recipient metabolic compatibility in IBS patients.

Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host

This study identifies BfaGC, a sphingolipid produced by Bacteroides fragilis, that facilitates neonatal colonization and immune modulation through metabolic adaptation.

A commensal-derived sugar protects against obesity by regulating immunometabolism

This study identifies a bacterial exopolysaccharide from Clostridium immunis that protects against obesity by modulating IL-22 levels in adipose tissue.