Gut microbiota and health

Exploratory multi-omics analysis reveals sex-specific differences in microbial response to antibiotic exposure

This study investigates sex-specific differences in microbial, metabolic, and immune responses to antibiotic exposure using a multi-omics approach in mice.

Alterations of gut microbiota in Down syndrome and their association with Alzheimer's disease

This study examines gut microbiota alterations in Down syndrome and their link to Alzheimer's disease biomarkers and cognitive decline.

Full-length 16S profiling reveals individualized gut microbiota dynamics during short-duration spaceflight

The paper profiles gut microbiota changes in astronauts during short-duration spaceflight and finds individualized, temporally localized shifts rather than uniform restructuring.

A strong-to-weak interaction shift during microbiome succession is coupled to colonizer-dependent antimicrobial resistance

This study tracks microbiome succession in mice, showing a shift from strong to weak interactions linked to colonizer-dependent antimicrobial resistance.

From Bile Acids to a Gas-Producing Microbiome Phenotype: A Novel Mechanism of Host-Microbiome Communication

The paper investigates how bile acids regulate bacterial gas production and its impact on host epithelial gene expression, revealing a novel host-microbiome communication mechanism.

Reconsidering the Use of Dimethyl Sulfoxide for Xenobiotic-Gut Microbiota Interaction Studies

This study shows that DMSO significantly alters gut microbiota metabolism and enriches Desulfovibrio desulfuricans, overshadowing xenobiotic effects.

Colonization of the gut microbiota with Akkermansia muciniphila ameliorates dysbiosis-mediated transplant arterial injury in female mice

This study shows that Akkermansia muciniphila reduces transplant arterial injury in mice by modulating immune responses and short-chain fatty acid levels.

A gavage-fomite based method to generate mouse models with natural microbiota

This paper introduces a gavage-fomite method to generate mice with natural microbiota, showing improved immune maturation and protection against bacterial challenges compared to traditional methods.

Deciphering the Gut-Brain Dialogue: A Survey-Based and In-Silico Comparative Analysis of Gut Microbial Dysbiosis in Common Neurological Disorders

This study surveys public awareness of the gut-brain axis and compares microbial dysbiosis in depression, anxiety, schizophrenia, and ASD using the Disbiome database.

Complete genome-derived metabolic interactions reveal impact of gut ecology on human health

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

A human microbiota-associated mouse model of early-life malnutrition reveals persistent microbiome immaturity and limited response to fecal viral transplantation

This study uses a human microbiota-associated mouse model to show that early-life malnutrition leads to persistent microbiome immaturity and that fecal virome transplants have limited efficacy in restoring gut health.

Gut microbiome signatures precede chronic kidney disease diagnosis in a large canine cohort

The paper identifies gut microbiome signatures associated with future chronic kidney disease in dogs, showing reduced diversity and specific genus abundance changes before diagnosis.

HuMMANet: A Harmonized Cross-Study Resource for Integrative Analysis of Human Gut Microbiome Metabolome Associations

HuMMANet harmonizes gut microbiome and metabolome data across 46 studies to identify reproducible metabolite-microbiome associations and their clinical relevance.

GTX-GUT: A Standardized Metagenomic Workflow for Gut Microbiome Profiling and Clinical Associations

GTX-GUT is a standardized metagenomic workflow for gut microbiome profiling that integrates quality control, taxonomic classification, and clinical association analysis, showing improved accuracy and reproducibility in microbiome studies.

Microbial-associated acylated putrescines as immunomodulatory molecules in inflammatory bowel diseases

The paper identifies N-acyl putrescines, particularly NOP, as immunomodulatory metabolites produced by gut microbiota that suppress inflammation in IBD models.

Host ecological context influences taxonomic diversity and functional conservation of gut microbiome across anthropogenic habitats in macaques

This study shows that gut microbiome responses to human disturbance in macaques depend on host ecology, with taxonomic and functional changes differing across species despite shared environmental exposure.

Gut Microbial Signals Influence Motivational Responses in the Male Mouse

This study shows that disrupting the gut microbiota increases reward-seeking behavior in male mice and alters brain gene pathways and inflammation.

Gut Microbiome Composition in Older Adults with PTSD Symptoms and Trauma-Exposed Controls: Findings from the GUMP Study

This study examines gut microbiome composition and function in older adults with PTSD symptoms versus trauma-exposed controls, finding differences in functional pathways but not taxonomic composition.

Description of canine- and feline-derived strains of the bile acid-converting bacterium Peptacetobacter hiranonis: P. hiranonis subsp. deconjugans subsp. nov. and P. hiranonis subsp. nondeconjugans subsp. nov.

This paper describes two new subspecies of Peptacetobacter hiranonis isolated from dogs and cats, highlighting genomic and functional differences in bile acid conversion.

Virulence studies of the human gut pathobiont Bilophila wadsworthia using Galleria mellonella as model host

This study evaluates Galleria mellonella as a model to study Bilophila wadsworthia virulence, showing systemic infection causes morbidity and revealing host-pathogen interactions.

Grey mouse lemurs, Microcebus murinus, are a relevant model to study gut microbiome flexibility in response to diet changes

This study investigates the gut microbiota of grey mouse lemurs under different dietary regimens, showing changes in composition associated with functional redundancy.

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment

This study shows that nicotinamide treatment reduces gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.

Small intestinal microbiota of undernourished women perturbs placentaldevelopment in mice

The paper shows that the gut microbiota of undernourished women negatively affects placental development in mice, with potential bacterial targets for improving prenatal outcomes.

Fecal metabolomics reveals preferential complex carbohydrate utilization and guides cultivation of murine gut Firmicutes

The paper uses metabolomics to identify complex carbohydrate utilization in murine gut microbiota and develops a new medium to cultivate previously unculturable Firmicutes.

Dietary macronutrients influence the gut microbiome and FA1PI, a non-invasive marker for GI health, in zoo-managed maned wolves (Chrysocyon brachyurus)

This study examines how dietary macronutrients affect gut microbiota and the biomarker FA1PI in maned wolves, linking fiber intake to improved GI health.

Global analysis of infant gut microbiota revealed distinctive maturation dynamics across lifestyles

This study analyzes global infant gut microbiota to reveal lifestyle-specific maturation patterns and identifies delays in maturation in malnourished and preterm infants.

D-Mannose treats obesity by increasing adipose Treg cells and suppressing gut Firmicutes

This study shows that D-mannose reduces obesity in mice by enhancing adipose Treg cells and decreasing gut Firmicutes bacteria.

An engineered Clostridial mini consortium modulates intestinal inflammation

The paper engineers a Clostridial consortium to study isoDCA's role in modulating intestinal inflammation and regulatory T cell induction.

Influence of high fibre diets on the gut microbiota, prostate tumour growth and normal tissue toxicity following ionising radiation

This study investigates how high-fiber diets affect prostate tumor growth, gut microbiota, and radiation toxicity in mice, finding fiber delays tumor growth and protects against radiation damage.