SARS-CoV-2 and COVID-19 Research

This study evaluates KP.2-based monovalent mRNA vaccines and finds they robustly boost neutralizing antibodies against current SARS-CoV-2 variants, including KP.3.1.1 and XEC.

This study shows that PLAC8 is required for SARS-CoV-2 infection of the pancreas and links pancreatic enzyme levels to COVID-19 severity.

This study examines immune responses in human nasal-associated lymphoid tissue after SARS-CoV-2 infection, revealing coordinated defense mechanisms involving monocytes, macrophages, B cells, and T cells.

This study evaluates antibody responses to a third dose of COVID-19 vaccine in kidney transplant recipients, finding reduced neutralizing antibodies and altered IgG subclass switching compared to healthy controls.

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

This study uses multi-omics analysis to show that dysregulated lung epithelial cell homeostasis and immune responses drive severe MERS-CoV disease in mice.

This study investigates the entry mechanisms of seasonal human coronaviruses NL63, 229E, and HKU1 using pseudoviruses and cell lines expressing ACE2, APN, or TMPRSS2, revealing endocytosis as the entry route and specific protease and receptor requirements.

The paper analyzes virological and antigenic traits of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1, finding trade-offs between immune evasion and ACE2 binding efficiency.

This paper describes a bacteriophage T4-based nanoparticle platform for designing dual COVID-19-Flu mucosal vaccines, showing robust immune responses and protection in mice.

This study maps the transcriptional and translational changes in human lung fibroblasts infected with HCoV-OC43, identifying new ORFs and ER stress response activation.

This study shows SARS-CoV-2 S, M, and E proteins reduce HIV-1 LTR activity and modulate ER stress by down-regulating NF-κB, while N protein does not.

The paper investigates the functional role of N-glycans in the S2 domain of beta-coronavirus spike proteins, showing their conservation across SARS-CoV-2, SARS-CoV, and MERS-CoV.

The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.

This study identifies FABP4 as a host target that modulates SARS-CoV-2 infection, showing that its inhibition reduces viral replication and lung damage in infected hamsters.

This study examines how SARS-CoV-2 variants and vaccination affect nasal immunity across three waves, identifying changes in cellular states and immune responses.

This study shows that a gamma-irradiated microneedle array patch vaccine against SARS-CoV-2 S1 protein provides long-lasting immunity and stability without refrigeration.

This paper introduces a scalable PPI screening method to identify interactions between SARS-CoV-2 and human proteins, identifying 74 putative interactions.

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

This study uses barcoded SARS-CoV-2 viruses in Syrian hamsters to show that transmission bottleneck varies by exposure duration and route, with direct contact having the largest bottleneck.

This study evaluates the fitness and pathogenesis of Omicron variants in the upper and lower respiratory tracts, finding increased URT fitness with reduced lung pathology.

The study investigates SARS-CoV-2 Omicron XBB.1.41.1 lineage shedding in captive white-tailed deer, finding higher mutation rates compared to human isolates.

This study shows that the nsp14-nsp10 interaction is essential for coronavirus replication and enzymatic activity, with specific interface residues critical for function.

This study shows that a specific lipid nanoparticle formulation enhances B- and T-cell responses and provides better protection against SARS-CoV-2 in hamsters.

The paper identifies a SARS-CoV-2 S2 protein-derived peptide (P3) with super-antigen-like properties that stimulate T-cells and induce proinflammatory cytokines in mice.

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

This study shows SARS-CoV-2 infection causes greater metabolic disturbance in peripheral lung tissue than central tissue, despite higher viral loads in the center.

This study analyzes amino acid substitutions in the SARS-COV-2 spike protein across VOCs, showing increased radical substitutions in key domains like NTD and RBD, and highlights the role of selective pressure in Omicron's evolution.

This study re-evaluates SARS-CoV-2 intrahost evolution rates in immunocompromised patients using multiple methods, finding no evidence of elevated rates compared to host-to-host transmission.