Cancer Immunotherapy and Biomarkers

This study shows that combined PD-1/CTLA-4 checkpoint inhibition worsens post-MI cardiac injury by promoting CD8+ T cell-driven macrophage activation through the JAK-STAT1 pathway.

The paper presents a cost-effective workflow combining multiplexed immunofluorescence and in situ proximity ligation assay to detect protein interactions and cell types in clinical samples.

The paper identifies a large class of non-canonical cancer-germline antigens (ncCGAs) from lncRNAs and mRNA untranslated regions, showing their potential as immunotherapeutic targets.

The paper identifies transcriptome-inferred CIN-like fields as markers of immune-cold, antigen-presentation-low neighborhoods in cancer tissues.

This paper identifies soluble CD155 as a systemic checkpoint that suppresses DNAM-1 signaling, leading to resistance to immune checkpoint inhibitors, and shows that an anti-sCD155 antibody can reprogram this signaling to enhance antitumor immunity.

This study predicts neoantigen repertoires in MPNSTs and identifies immune-related differences between PRC2-Loss and PRC2-WT subtypes, highlighting potential immunotherapy targets.

This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.

The paper identifies a novel class of mature lymphoid aggregates in NSCLC using spatial proteomics and develops a classifier to improve CPI biomarker eligibility.

The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.

This study identifies ATF4 as a key driver of immune evasion in β-catenin-driven hepatocellular carcinoma by programming a proline-dependent metabolic axis that suppresses anti-tumor immunity.

This study shows that stem-like CD8+ T cells, when used in adoptive cell therapy followed by vaccination, improve tumor control by altering the tumor microenvironment's transcriptomic profile.

This paper redefines pancreatic adenocarcinoma immunotherapy resistance by identifying a 'Brake-with-Wall' phenotype where functional T cells are trapped behind a fibroblast wall, suggesting that triple-targeted intervention may be needed.

This study investigates ICI-related kidney injury in a humanized mouse model, identifying immune biomarkers and mechanisms of nephrotoxicity.

This paper identifies ME1 as a key regulator of reversible T cell exhaustion and develops a mathematical model to predict ICI responsiveness based on latent effector capacity.

This study uses single-nucleus RNA-seq to analyze RCC brain metastases, identifying immune evasion mechanisms and metabolic adaptations that contribute to resistance to therapy.

This study shows that stabilizing the GITRL ligand enhances antitumor immunity by enabling physiological signaling between APCs and T cells, unlike receptor-targeted antibodies.

This study identifies TIGIT-NECTIN2/3 signaling as a mechanism preserving ignorant CD8⁺ T cells in HBV-related HCC, enhancing immune checkpoint inhibitor efficacy.

The paper examines the spatial organization of dendritic cell subsets in NSCLC patients treated with anti-PD1 and finds that cDC1-driven patterns correlate with prolonged ICB response.

This paper shows that combining IRE with anti-PD-1 induces abscopal effects in PDAC by triggering immune activation and systemic antitumor responses.

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.

This study shows that Survivin inhibition increases PD-L1 expression via cGAS stabilization, leading to immune evasion and reduced antitumor immunity.

The paper shows CMAS in melanoma cells correlates with poor survival and reduced response to immunotherapy by altering tumor-immune interactions.

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

This paper introduces a hierarchical spatial graph neural network to classify tertiary lymphoid structures as immunogenic or tolerogenic in renal cell carcinoma using spatial transcriptomics data.

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

The paper identifies extrafollicular plasma cells as an antibody-independent checkpoint that inhibits dendritic cell-T-cell priming in tumor-draining lymph nodes, leading to poor prognosis and immune-checkpoint resistance.