Developmental Biology and Gene Regulation

This study identifies SOX2+ sustentacular cells as stem cells for postnatal adrenal medulla chromaffin cells, showing their ability to generate both adrenaline and noradrenaline lineages and maintain homeostasis via WNT6 secretion.

The paper identifies a master regulatory loop in ascidian muscle cells that controls both spatial and temporal gene expression patterns.

The paper develops a core mathematical model of BMP signaling that can replicate gradient dynamics in both Drosophila and zebrafish with minimal parameter changes.

The paper shows that spinal cord elongation drives proportional regulation of the zebrafish posterior body after neural progenitor reduction.

This study shows Flamingo (Fmi) is required for cell competition in Drosophila, functioning in both malignant and healthy contexts through a mechanism independent of planar cell polarity.

This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.

This study identifies a novel role for Hox13 in regulating newt hindlimb bud outgrowth by interacting with Fgf10 and Tbx4 during development.

This study shows that dedifferentiated tumour neural stem cells in Drosophila generate a glial niche that supports tumour growth through dysregulated ecdysone signalling.

This study shows that physical size affects morphogenetic timing and outcomes in gastruloids, while transcriptional programs remain stable, with extreme sizes showing distinct gene expression patterns.

The paper identifies conserved and divergent transcriptional signatures in neural crest cells across chick and mouse embryos during migration.

This paper demonstrates that stem cell self-renewal can occur without niche feedback or fine-tuning through a dimerization cycle mechanism.

This study shows that marsupial limb development bypasses lateral plate mesoderm subdivision, challenging previous models of tetrapod limb formation.

The paper uses single-cell transcriptomics to study vertebrate trunk formation, identifying signaling pathways that regulate notochord and tissue development in human pluripotent stem cells.

This paper investigates how gene loss and duplication in Fgf subfamilies influenced chordate evolution, particularly in appendicularians, revealing evolutionary patterns and functional shifts.

The paper shows how the epithelial-mesenchymal boundary directs cell shape alignment and axis elongation in Xenopus animal cap explants without external cues.

The paper shows that collective cell fate decisions and mechanical differences drive symmetry breaking in gastruloids through a mechanochemical mechanism.

This study investigates the role of Dlx5/6 genes in the coordinated development of mammalian vocal and auditory organs through mutant mouse models, revealing pleiotropic effects on multiple systems.

The paper identifies E93 as a repressor of broad (br) to enable adult differentiation in Drosophila by preventing premature activation of pupal-specific enhancers.

This study traces the developmental origin of caudal fin muscles in zebrafish using lineage tracing, identifying unique muscle fiber origins in teleosts.

This study investigates how size affects morphogenesis and transcriptional profiles in mouse gastruloids, revealing size-dependent changes in axial elongation and tissue composition.

The paper investigates how sexual dimorphism and left-right asymmetry interact in duck syrinx development, showing that PITX2 and estrogen signaling regulate asymmetric growth differently in males and females.

The paper shows that temporal BMP/Nodal signaling ratios drive tissue-specific convergence and extension movements during zebrafish gastrulation.

This paper shows how Notch and RTK signals interact to specify the Drosophila R7 photoreceptor fate through transcriptional regulation of phyl and svp.

This study examines spinal neural tube formation and tail development in human embryos, finding patterns similar to mouse and rat, including primary neurulation completion and secondary neurulation characteristics.

This study reconstructs the mesodermal origins of neck muscles in vertebrates, showing that neck evolution arose from pre-existing muscle groups in fishes through developmental expansion.

The paper identifies a microRNA-mediated negative feedback loop regulating Rbfox1 and its targets during Drosophila myogenesis.

This study identifies the signaling pathways and conditions required to generate notochord progenitors from human pluripotent stem cells in vitro.

This study investigates the role of Caspar in Drosophila melanogaster, showing it regulates primordial germ cell count and identity through interactions with Smaug and effects on Oskar protein levels.

The paper uses single-cell RNA sequencing to compare embryonic development in two sea urchin species, identifying evolutionary changes in cell fate specification and signaling.

This study identifies ancient Wnt-dependent habenular asymmetries in sharks, suggesting a conserved developmental mechanism across jawed vertebrates.