Developmental Biology and Gene Regulation

The paper defines the Drosophila airway progenitor field through three cooperative regulatory programs and their roles in morphogenesis.

The paper shows that early cytokinesis drives cytoskeletal reorganization in zebrafish Kupffer's vesicle, enabling lumen formation and detachment from the enveloping layer.

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

This study investigates how Hedgehog signaling coordinates oscillatory atonal gene expression in Drosophila eye development.

This study shows Med12 and Med13 prevent dedifferentiation of intermediate neural progenitors and loss of neural stem cells in Drosophila by regulating gene expression through interactions with different mediator complex subsets.

This study identifies the role of BMP antagonists in sustaining mandibular growth in zebrafish by regulating chondrocyte differentiation and cartilage organization.

The paper maps scRNA-seq from stem cell-based axial organoids to a human embryo, revealing three origins of axial development and the neural bias of neuromesodermal progenitors.

The paper identifies a tunnel microtract (TMT) as a neural crest-derived organ essential for T cell progenitor homing, showing Sox10-Cdc42 signaling drives its formation in zebrafish and mice.

The paper provides the full-length sequence of DUXC mRNA from bovine embryos and investigates its genomic organization and expression patterns.

The paper estimates the information content of developmental landscapes in two systems by integrating developmental biology, information theory, and dynamical systems.

This paper investigates the role of Lmx1 in Ciona neural tube closure, finding that its knockdown causes defects and overexpression disrupts cell intercalation, suggesting a conserved role in chordate morphogenesis.

This study investigates how gene regulatory network co-option drove the evolution of a dipteran respiratory organ through ecological and evolutionary changes.

This study creates a single-cell RNA sequencing atlas of sheep embryos to understand symmetry breaking and identifies conserved and species-specific molecular programs across eutherian mammals.

This study identifies the Mediator complex as a key regulator of hypertranscription in Drosophila neural stem cells, showing its necessity for proper differentiation and stem cell fate.

The paper examines inner ear morphogenesis across 12 vertebrate species, finding that divergent mechanical processes in tissue expansion are coordinated with developmental tempo to maintain conserved morphology.

The paper reconstitutes planar polarity initiation in an engineered epithelial system, showing collective migration breaks symmetry and drives polarity across scales.

The paper identifies a phospho-switch in SALL4 that controls cell fate by modulating BAF complex interaction in response to BMP4-DUSP9 signaling, causing developmental defects when disrupted.

The paper shows that reversing active chiral torques in C. elegans leads to mirrored embryos and situs inversus, demonstrating their role in determining body plan handedness.

The paper models how progenitor addition and vacuolation interact in zebrafish notochord development, showing a feedback mechanism that maintains tissue proportions during elongation.

The paper shows that injured Drosophila gut polyploid enterocytes dedifferentiate into diploid progenitors via paligenosis, involving autophagy and TORC1.

This study shows that the Drosophila sex comb evolved through changes in developmental tempo and energy metabolism, not by co-opting new genes into downstream networks.

The paper uses transcriptomics to study PIE-1's role in maintaining germline identity in C. elegans embryos by comparing somatic and germline blastomeres with and without PIE-1.

The paper quantifies Dorsal/NF-κB mobility and DNA binding along the dorsal-ventral axis of Drosophila embryos, revealing a gradient in DNA binding that affects gradient formation and downstream gene expression.

The paper provides a high-resolution spatial transcriptomic and proteomic map of early primate gastrulation, identifying key cell populations and signaling networks.

This study shows that dorso-ventral patterning genes in paired fins are conserved in median fins, supporting an ancient origin of the DV regulatory module that was redeployed during paired fin evolution.

The paper challenges the traditional view that morphogen concentration fluctuations determine transition zone width, showing instead that cellular readout noise is the key factor.

This study shows PRDM16 is essential for trigeminal ganglion development and sensory neuron differentiation in zebrafish and mice.

The paper uses single-cell multiomics to identify key regulatory nodes and cis-regulatory elements in zebrafish eye development.

This study identifies MYRF as a master temporal regulator in C. elegans larval development, showing it drives oscillatory gene networks and stage transitions through microRNA activation and feedback loops.

This study uses single-cell RNA sequencing to trace endoderm cell trajectories in Styela clava, revealing dual origins of the digestive tract and conserved regulatory programs across chordates.