Hearing, Cochlea, Tinnitus, Genetics

Social-Cognitive Dysregulation Model of Misophonia: Perspective from a Behavioural Study

This study investigates misophonia through a social-cognitive lens, finding associations between severity and deficits in mental-state inference, emotion recognition, and self-other representation.

Feasibility of Using Functional Near-Infrared Spectroscopy for Characterizing Misophonia-Related Brain Activity

This study evaluates the feasibility of using fNIRS to detect misophonia-related brain responses and finds it effective in measuring neural and physiological reactions to trigger sounds.

Hyperpolarization-activated cation channels confer tonotopic specialization for temporal encoding of sound frequency in the cochlear nucleus

The paper identifies a tonotopic gradient of hyperpolarization-activated cation channels (IH) in the nucleus magnocellularis that enhances temporal encoding of sound frequency.

SEDATION DIFFERENTIALLY AFFECTS DISTORTION-PRODUCT AND STIMULUS-FREQUENCY OTOACOUSTIC EMISSIONS IN CHINCHILLAS

This study examines how sedation affects distortion-product and stimulus-frequency otoacoustic emissions in chinchillas, finding elevated low-frequency DPOAE amplitudes and variable SFOAE changes under sedation.

Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line

The paper uses electrophysiological recordings to study exocytic properties of zebrafish lateral line hair cells during development, finding no positional variation but reduced capacitance in tail-region cells and a role for otoferlin b.

Auditory brainstem response latencies, but not amplitudes, are associated with gray matter volumes across the human auditory pathway in older adults

This study finds that ABR latencies, not amplitudes, correlate with gray matter volumes in specific auditory pathway regions in older adults.

A mechanism for attenuating responses to anticipated sounds in the dorsal cochlear nucleus

The paper investigates the role of cartwheel cells in the dorsal cochlear nucleus, showing they use anti-Hebbian plasticity to enhance inhibition of output neurons during anticipated sounds.

Ototoxicity-induced inner-hair-cell specific dysfunction degrades neurometric modulation detection in noise without altering peripheral tuning

This study shows that IHC dysfunction impairs temporal-envelope coding in auditory-nerve fibers without altering peripheral tuning, contributing to hidden hearing loss.

Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

Cochlear Innate Immune Homeostasis is altered in the Oncomodulin-Deficient Mouse Model

This study examines how the absence of oncomodulin in mice affects cochlear innate immunity, finding changes in macrophage density and morphology without significant cytokine differences.

SOX2-dependent enhancer activation couples epithelial identity to neuronal maintenance

This study shows that SOX2 maintains regulatory continuity between cochlear epithelium and spiral ganglion neurons by sustaining enhancer activity and neurotrophic gene expression.

Aging Alters Hair Cell Physiological Properties in Mice with Late-Onset Age-Related Hearing Loss.

This study shows that hair cell function declines with age in mice before hearing loss is detectable, challenging the idea that stereocilia are the most fragile part of sensory cells in aging.

Noise-induced temporary threshold shift in macaques disrupts electrophysiological temporal processing despite recovery of cochlear sensitivity and preserved ribbon synapse counts

This study shows that temporary threshold shift in macaques causes lasting impairments in temporal auditory processing despite normal hearing thresholds and preserved hair cells.

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.

Stability of eye movement-related eardrum oscillations to acoustic and gravitational/postural manipulations

This study investigates whether acoustic and gravitational/postural manipulations affect the time course of eye movement-related eardrum oscillations (EMREOs), finding no significant modulation.

A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

This study identifies the auditory nerve glial transition zone as a critical site of age-related immune and glial dysfunction contributing to hearing loss.

Adaptive immune responses are not causal to SGN death after kanamycin-induced hair cell loss

This study investigates the role of adaptive immune responses in spiral ganglion neuron (SGN) death after kanamycin-induced hair cell loss in rats, finding that T cells are not necessary for neurodegeneration but lymphocytes may play a role in specific regions.

PALM3 and hearing loss: a potential dual diagnosis interfering with novel gene discovery

The paper identifies a homozygous splice-site variant in PALM3 and a missense variant in OTOA in a family with autosomal recessive hearing loss, supporting PALM3 as a candidate gene through functional and comparative analysis.

An Objective Detection Method for Tinnitus using Memristors

This paper develops a memristor-based method to objectively detect tinnitus using serum from human and mouse samples, showing high discrimination between tinnitus and non-tinnitus individuals.

Evidence of phase resetting, not just pulses of sound, during eye movement-related eardrum oscillations (EMREOs)

The paper investigates whether eye movement-related eardrum oscillations (EMREOs) are caused by sound pulses or phase resetting during saccades, finding that phase resetting is more prevalent.

Chronic stress does not induce behavioural signs of tinnitus or cochlear synaptopathy in Mongolian gerbils

This study shows that chronic stress alone does not cause tinnitus or cochlear synaptopathy in Mongolian gerbils, suggesting stress may not be a primary cause of tinnitus.

Which phonetic contrasts recover information lost to aggregate speech scoring in auditory nerve disorders: a computational framework

The paper develops a computational framework to identify phonetic contrasts that recover information lost in speech scoring for auditory nerve disorders by simulating different pathophysiological mechanisms.

Molecular and cell type-specific determinants of inferior colliculus development and auditory function

This study identifies gene regulatory programs and cell type-specific molecular mechanisms underlying inferior colliculus development and auditory function.

Hydrostatic pressure shapes and canalizes semicircular canal morphology to ensure vestibular function

The paper shows hydrostatic pressure from the inflating otic vesicle shapes zebrafish semicircular canals, driving pillars toward a common geometry and ensuring vestibular function.

Spatial Patterning of Otic Vesicles in Human Inner Ear Organoids

The paper assesses axial patterning in human inner ear organoids and finds incomplete and disorganized regionalisation, suggesting limitations in self-organization and potential strategies to enhance cell complexity in vitro.

Patient-Derived Inner Ear Organoids as a Disease Modeling and Therapy Validation Platform For Hereditary Inner Ear Disorders

This study develops patient-derived inner ear organoids to evaluate antisense oligonucleotide therapies for hereditary hearing loss, showing effective ASO uptake and splice correction in disease models.

Genetic Targeting and Conductance-Based Modeling Reveal Novel Diversity Within Mouse Type II Spiral Ganglion Neurons

This study identifies biophysical and ion channel diversity in mouse type II spiral ganglion neurons using genetic tools and computational modeling, revealing distinct subtypes with potential functional differences.

Temporal integration in the subcortical auditory system and behavioral evidence of its dysfunction after "temporary" noise-induced hearing loss

This study examines temporal integration in the subcortical auditory system of nonhuman primates before and after noise exposure, finding disrupted psychometric integration and increased dynamic range post-exposure.

Peripheral phoneme encoding and discrimination in aging and hearing impairment

The paper examines how aging and hearing impairment affect speech encoding and phoneme discrimination using EEG and behavioral tests, finding age-related declines in high-frequency envelope coding but preserved low-frequency encoding.

Resolving early cochlear inflammation prevents lasting damage from noise exposure

This study identifies quinoxaline derivatives that prevent noise-induced hearing loss by targeting early inflammatory signaling in zebrafish and mouse models.