Hearing, Cochlea, Tinnitus, Genetics

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

The paper shows that combinatorial Maf transcription factors establish subtype-specific synaptic properties in spiral ganglion neurons.

Auditory Brainstem Responses in Two Closely Related Peromyscus Species (Peromyscus leucopus and Peromyscus maniculatus)

This study compares auditory brainstem responses (ABRs) between two Peromyscus species, finding species-specific differences in craniofacial morphology and ABR latency but similar hearing thresholds.

Neural Onset and Offset Responses in Core and Belt Auditory Cortex of Young and Aged Alert Macaque Monkeys

This study examines age-related changes in auditory cortex neuronal responses in macaques, finding reduced spectral precision and temporal fidelity in the belt area CL compared to core areas.

Title: The RNA-binding protein TRIM71 is essential for hearing in humans and mice and regulates the timing of auditory sensory organ development

This study identifies TRIM71 as essential for hearing in humans and mice, showing it regulates the timing of auditory sensory organ development and prevents premature hair cell differentiation.

Stereocilium height changes can account for the calcium dependence of the outer-hair-cell bundle's resting state

The paper proposes a mechanism by which extracellular calcium regulates the resting state of outer-hair-cell bundles through changes in stereocilium height and builds a model to support this hypothesis.

Rapid FFR: A rapid method for obtaining Frequency Following Responses

This paper introduces Rapid FFR, a method that improves FFR recording efficiency by using continuous stimulation and cycle averaging, showing higher signal quality and reliability compared to conventional methods.

Medial olivocochlear efferent modulation of cochlear micromechanics requires P2X4 expression in outer hair cells

This paper investigates the role of P2X4 receptors in cochlear outer hair cells, showing their involvement in auditory function and micromechanical modulation through genetic knockout studies in mice.

Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1

The paper identifies small molecule modulators of TMC1 channels using structure-based screening and validates their effects on dye uptake in cochlear explants.

Mechanisms of Tone-in-Noise Encoding in the Inferior Colliculus

The paper investigates how the inferior colliculus encodes tone-in-noise stimuli, finding that wideband TIN responses involve broad inhibition while narrowband responses depend on envelope fluctuations.

Forward masking in the Inferior Colliculus: Dynamics of Discharge-rate Recovery after Narrowband Noise Maskers

The paper investigates how discharge-rate recovery in IC neurons occurs after narrowband noise maskers, finding that full recovery requires long inter-trial intervals.

The Computational Auditory Signal Processing and Perception Model (CASP): A Revised Version

This paper revises the CASP model to improve its accuracy and usability by incorporating a more realistic non-linear inner hair cell model and enhancing decision-making strategies.

Slow Outer Hair Cell Contractions Are Essential for Fast Electrical Responses to Intense Sound.

The paper shows that slow outer hair cell contractions enable fast electrical responses to intense sound, revealing a kinetic relationship essential for cochlear protection and temporal fidelity.

Single neuron contributions to the auditory brainstem EEG

This study quantifies single neuron contributions to the auditory brainstem response (ABR) in barn owls, showing that individual neurons contribute to ABR wave II.

Age-related decline in neural phase-locking to envelope and temporal fine structure revealed by frequency following responses: A potential signature of cochlear synaptopathy impairing speech intelligibility

This study shows that age-related declines in neural phase-locking to both envelope and temporal fine structure, measured via FFRs, are linked to cochlear synaptopathy but not speech intelligibility.

Activation of complement protein C3 depicts the dynamic tissue damage of the cochlea after noise trauma.

This study investigates the role of complement protein C3 in cochlear tissue damage after noise trauma, finding dynamic C3 activation and its involvement in damage recognition and clearance.

Three-row stereocilia model predicts mammalian hair bundle behavior

The paper develops a mathematical model of mammalian outer hair cell hair bundles with three rows of stereocilia, showing it predicts mechanical creep and MET current adaptation in response to stimuli.

Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants

The paper models how auditory deprivation-induced axon initial segment plasticity in MSO neurons reduces time difference sensitivity in cochlear implant users.

PROX1 Controls Cellular Patterning, Innervation and Differentiation in the Mouse Organ of Corti

This study shows that PROX1 is essential for the differentiation and organization of lateral compartment supporting cells in the mouse organ of Corti, which indirectly affects innervation patterns.

An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

The paper explains how octopus cells in the auditory brainstem detect coincident inputs on both millisecond and submillisecond time scales, enhancing the ability to process complex sounds.

Sound-Evoked Plasticity Differentiates Tinnitus from Non-Tinnitus Mice

The paper identifies tinnitus-specific differences in sound-evoked plasticity using the LDS test in mice, showing distinct patterns in neuronal activity and auditory brainstem responses.

Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

This study investigates age-related changes in the auditory cortex of mice, finding reduced excitatory bandwidth, altered spectral tuning diversity, and weakened sideband inhibition in L2/3 neurons.

PIP2-Tmie Interactions Drive Mammalian Hair Cell Slow Adaptation Independently of Myosin Motors

This study shows that PIP2-Tmie interactions, not myosin motors, drive slow adaptation in mammalian hair cells, as demonstrated by rescue experiments and disruption studies.

ABRpresto: An algorithm for automatic thresholding of the Auditory Brainstem Response using resampled cross-correlation across subaverages

ABRpresto automatically estimates ABR thresholds using resampled cross-correlation across subaverages, achieving 92% accuracy within ±10 dB of human ratings on mouse data.

Modification and validation of a GAD-GFP mouse line without accelerated aging-related hearing loss.

The paper modifies a GAD-GFP mouse line to reduce hearing loss and validates its improved auditory function and GFP expression in GAD+ neurons.

Lipidomics profiling identifies β-oxidation as a key process in noise-induced hearing loss

The paper identifies β-oxidation as a key process in noise-induced hearing loss using lipidomics profiling and validates it with Etomoxir treatment.

Virally-Mediated Enhancement of Efferent Inhibition Reduces Acoustic Trauma in Wild Type Murine Cochleas.

Viral transduction of a gain-of-function nAChR enhances native cholinergic inhibition to protect the cochlea from noise-induced hearing loss.

Select autosomal dominant DFNA11 deafness mutations activate Myo7A in epithelial cells

The paper identifies DFNA11 deafness mutations that activate Myo7A motor activity in epithelial cells, linking them to autosomal dominant inheritance.

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

This study improves optogenetic modification of spiral ganglion neurons in gerbils using microcatheter-based AAV delivery, achieving reliable ChR expression in 80% of treated animals but with limited transduction efficiency.

Auditory efferents facilitate intensity change detection in humans: evidence from concurrent ear, brain, and behavior measures

The paper investigates the role of the medial olivocochlear reflex in human auditory perception by measuring ear, brain, and behavioral responses to intensity changes.

Methionine sulfoxide reductase B3 antioxidant activity is indispensable for mouse inner ear cuticular plate structure and hair bundle integrity

This study shows that MSRB3 is essential for maintaining inner ear structure and hair bundle integrity in mice, with its antioxidant activity protecting actin redox dynamics.