Hearing, Cochlea, Tinnitus, Genetics

A human spiking computational model to explore sound localization

This paper develops a spiking neural network model of human auditory brainstem nuclei to study sound localization mechanisms using ITDs and ILDs.

ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

The paper identifies ybx1 as a key regulator promoting rapid hair cell regeneration in zebrafish lateral-line neuromasts by upregulating atoh1a, using the DELAY algorithm to infer gene regulatory networks.

Distribution of metabotropic serotonergic receptors in GABAergic and glutamatergic neurons in the auditory midbrain

The paper investigates the distribution of metabotropic serotonergic receptors in GABAergic and glutamatergic neurons of the auditory midbrain and finds differential receptor expression patterns.

Distortion rules: audibility creation in the mosquito ear

The paper reveals how male mosquitoes generate audible distortion tones from inaudible high-frequency sounds to detect female flight tones in noisy environments.

Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity

The paper identifies gene expression changes in the vestibular sensory epithelium during chronic ototoxicity, finding early downregulation of HC-specific genes and upregulation of stress mediators across species and compounds.

Live-cell single-molecule fluorescence microscopy for protruding organelles reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of inner ear hair cells

This study uses live-cell single-molecule fluorescence microscopy to investigate MYO7A trafficking in stereocilia, revealing its dimeric form and movement restrictions mediated by plasma membrane and F-actin interactions.

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration.

This study shows that Jagged1/Notch signaling maintains cochlear supporting cell progenitor-like characteristics and metabolic genes, and its inhibition enhances hair cell regeneration.

Multifaceted role of RIMBP2 in promoting hearing in murine cochlear hair cells

This study investigates the role of RIMBP2 in murine cochlear hair cells, finding it essential for OHC survival and critical for IHC exocytosis.

Alterations in steady-state synchronisation between Acute and Chronic Tinnitus suggests reduction in both tinnitus and central gain.

The paper investigates changes in auditory steady-state response (ASSR) in tinnitus patients and finds no significant amplitude differences between acute and chronic tinnitus but notes reduced amplitude in tinnitus groups compared to controls.

Haploinsufficiency of KPNA7 causes otosclerosis, likely due to the release of import inhibition of PTHrP and the reactivation of chondrogenesis in the globuli interossei

This study identifies a KPNA7 mutation causing otosclerosis by disrupting PTHrP nuclear transport and reactivating chondrogenesis in the otic capsule.

Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

This study shows that enhancing medial olivocochlear feedback protects against early noise-induced hearing damage in mice, with long-term auditory benefits.

Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses

This study investigates the developmental plasticity of cochlear inner hair cell ribbon synapses using live-cell imaging, revealing activity-dependent mechanisms in their structural maturation.

prdm1a drives a fate switch between hair cells of different mechanosensory organs

This study shows prdm1a drives a fate switch between zebrafish lateral line and ear hair cells, altering morphology and transcriptome.

Perceptual Novelty in Tinnitus a Causative Factor for its Persistence. A Stimulus Novelty Based P300 Paradigm on Acute, Chronic, and Non-Tinnitus Controls

The paper investigates how perceptual novelty contributes to tinnitus persistence by analyzing P300 responses in acute, post-acute, chronic tinnitus, and control groups.

Insights into early cochlear damage induced by potassium channel deficiency

This study shows KCNQ4 deficiency causes cochlear dysfunction by disrupting protein localization, OHC organization, and cell survival, with noise not worsening hair cell damage in the model.

Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models

The paper models outer hair cells as coupled oscillators to show how they overcome impedance mismatch and amplify basilar membrane motion, supporting the cochlea's high-frequency performance.

Evidence for a Transient State of Auditory Hypersensitivity During Initial Onset of Tinnitus, Evidenced by Intensity Dependence of the Auditory Evoked Potential (IDAEP)

The paper investigates tinnitus onset by analyzing IDAEP slopes, finding increased sensory reactivity during acute tinnitus that decreases over time.

Increased listening effort and cochlear neural degeneration underlie speech-in-noise deficits in normal hearing middle-aged adults

Fusiform Cells in the Dorsal Cochlear Nucleus Change Intrinsic Electrophysiological Properties and Morphologically Remodel Their Basal Dendrites with Age

This study examines age-related changes in fusiform cells of the dorsal cochlear nucleus in mice, finding stable physiology post-weaning but altered firing properties and dendritic complexity during ARHL onset.

Paralemmin-3 sustains the integrity of the lateral plasma membrane and subsurface cisternae of auditory hair cells

This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.

Responses of inferior colliculus neurons to notched noises in awake mice: putative neural correlates of auditory enhancement and Zwicker tone

The paper investigates how inferior colliculus neurons in awake mice respond to notched noises, showing suppression during stimulation and enhancement after, with implications for auditory enhancement and Zwicker tone mechanisms.

CASZ1 regulates the rate at which outer hair cells mature and is required for hearing

This study shows that CASZ1 regulates outer hair cell maturation and is essential for hearing by controlling gene expression and F-actin density.

Sex Differences in Auditory Brainstem Responses in the Hispid Pocket Mouse (Chaetodipus hispidus)

The paper assesses sex differences in auditory brainstem responses (ABRs) and morphological features in hispid pocket mice, finding significant sex differences in hearing thresholds but not in amplitudes, latencies, or craniofacial dimensions.

Comprehensive Genetic Profiling of Sensorineural Hearing Loss Using an Integrative Diagnostic Approach

This study uses whole-genome sequencing and functional assays to improve genetic diagnosis of sensorineural hearing loss, achieving a 55.6% diagnostic yield through comprehensive genomic profiling.

Tinnitus perception is linked to arousal system dysfunction

This study investigates cognitive difficulties in tinnitus patients and finds reduced arousal system function, with no specific executive dysfunction linked to tinnitus.

Subject Instructions for Improved Characterization of Auditory Representations Using Reverse Correlation

This study investigates how different subject instructions affect the quality of auditory representation characterization using reverse correlation, finding that detecting a hidden signal in stimuli yields the best reconstruction.

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplification

This study investigates how mutations in prestin affect cochlear amplification and hearing, finding that reduced prestin function leads to frequency-specific hearing loss but not complete deafness.

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

On the potential sources of a low-frequency sound percept only a few can perceive

The paper investigates low-frequency sound percepts (LFSPs) by comparing hearing thresholds and spontaneous otoacoustic emissions in individuals with and without LFSPs, suggesting subjective tinnitus as a likely cause.

Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

The paper compares SFOAE-based and behavioral measures of cochlear tuning in budgerigars, finding that SFOAEs accurately predict cochlear tuning while behavioral tuning shows unique patterns.