Circadian rhythm and melatonin

A cryptochrome photoreceptor controls animal light-dependent growth and lifespan via evolutionary conserved hormonal pathways

This study shows that cryptochrome loss in marine bristleworms increases lifespan and size, with hormonal pathways linked to sexual development and reproduction.

Melatonin Enhances Sleep via MT1-Driven Activation of Slo1 in Suprachiasmatic Nucleus Neurons

This study identifies a molecular pathway where melatonin promotes sleep by activating BK channels (Slo1) via MT1 receptors in SCN neurons, revealing a core circadian mechanism for sleep regulation.

Genome-wide association study of human pineal gland volume as proxy for melatonin secretion

This study conducts a GWAS of human pineal gland volume, identifying 34 genome-wide significant loci and highlighting genes and pathways related to sleep, metabolism, and neurodegeneration.

Hair test reveals plasticity of human chronotype

HairTime estimates chronotype from a single hair sample, showing it is influenced by age, sex, and work schedules, with lower circadian amplitude reducing prediction accuracy.

Evolution of circadian clock and light-input pathway genes in Hemiptera

The paper identifies and analyzes circadian clock and light-input pathway genes in Hemiptera, revealing lineage-specific gene losses and splicing variants, as well as a horizontal gene transfer event.

Dual-Approach Co-expression Analysis Framework (D-CAF) Enables Identification of Novel Circadian Regulation From Multi-OmicTimeseries Data

The paper introduces D-CAF, a framework for co-expression analysis of multi-omic time-series data, identifying novel circadian-regulated pathways in mouse macrophages.

Neuropeptide-dependent spike time precision and plasticity in circadian output neurons

This study investigates how neuropeptides Dh31 and Dh44 modulate spike time precision and plasticity in Drosophila circadian output neurons, revealing their role in circadian clock neural coding for sleep.

Correlation between circadian and photoperiodic latitudinal clines in Drosophila littoralis

The paper examines the correlation between circadian clock parameters and photoperiodic latitudinal clines in Drosophila littoralis, finding they align with diapause induction thresholds.

Circadian clock features define novel breast cancer subtypes and shape drug sensitivity

This study identifies circadian clock subtypes in breast cancer and shows their impact on drug sensitivity.

Suprachiasmatic Neuromedin-S Neurons Regulate Arousal

This study identifies SCN Neuromedin-S neurons as regulators of arousal, sleep-wake cycles, and body temperature rhythms through circuit analysis and single-nuclei RNA-Seq.

Photoperiod decoder 1 regulates seasonal changes in energy metabolism through the growth hormone signaling pathway

This study identifies phod1 as a gene regulating seasonal energy metabolism via the growth hormone pathway in Japanese medaka fish.

Functional and morphological alterations of the light perception circuits in postmortem retina from donors at different stages of Alzheimer's disease

This study examines structural and functional changes in intrinsically photosensitive retinal ganglion cells (ipRGCs) in Alzheimer's disease, finding severe loss and altered function of these cells that may contribute to circadian rhythm disruption.

Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex

The paper shows that melanopsin ganglion cells, not rod/cone photoreceptors, drive the pupillary light reflex under high light conditions in mice.

BMAL1 Overexpression in Suprachiasmatic Nucleus Protects from Retinal Neurovascular Deficits in Diabetes

This study investigates the protective effects of BMAL1 overexpression in the suprachiasmatic nucleus on neurovascular deficits in diabetic mice, showing improvements in circadian rhythms, retinal function, and glucose homeostasis.

Diurnal variation in skeletal muscle mitochondrial function dictates time of day-dependent differences in exercise capacity

This study identifies diurnal variation in mitochondrial function as a key determinant of time-of-day-dependent exercise capacity in skeletal muscle.

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensation

The paper identifies a conserved PER-DBT interaction critical for circadian timing and temperature compensation through structural and functional analyses in Drosophila and human cells.

Evening blue light exposure during adolescence induces avoidance behaviors and rewires medial amygdala circuit.

This study shows that evening blue light exposure in adolescent mice increases avoidance behaviors and changes medial amygdala circuitry.

Non-visual light modulates behavioral memory and gene expression in C. elegans

This study shows visible light affects behavioral memory and gene expression in C. elegans through a non-visual pathway involving cyp-14A5 and bZIP transcription factors.

Inferring circadian rhythm disruptions in cancer using phase differences between clock genes

The paper develops a method to infer circadian rhythm disruptions in tumors using phase differences between clock genes, finding cancer-type-specific alterations affecting patient survival.

Standardized and calibrated light stimuli via head-mounted displays for investigating the non-visual effects of light

This study uses VR head-mounted displays to deliver standardized light stimuli and finds melatonin suppression in 75% of participants.

Comparative transcriptomic rhythms in the mouse and human prefrontal cortex

This study compares circadian transcriptomic rhythms in mouse and human prefrontal cortex subregions, finding conserved signaling with sex-specific phase shifts and species-specific rhythmic transcript identities.

Effects of sex, mating status, and genetic background on circadian behavior in Drosophila

This study examines how sex, mating status, and genetic background affect circadian behavior in Drosophila, finding sex-specific period length differences and mating status-dependent rhythm strength changes.

Sinusoidal regulation denoises circadian machinery

The paper investigates how the waveform of regulatory functions affects period fluctuations in the circadian output system and finds that sinusoidal regulation minimizes these fluctuations.

Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation

This study shows that melatonin, not light, primarily drives circadian regulation of melanin synthesis and melanophore proliferation in Xenopus laevis, with melatonin mimicking dark-phase gene expression.

Circadian regulation of key physiological processes by the RITMO1 clock protein in the marine diatom Phaeodactylum tricornutum

This study identifies RITMO1 as a key circadian regulator in the diatom Phaeodactylum tricornutum, showing its impact on fluorescence, photosynthesis, and clock-controlled gene expression.

Food-entrainment of circadian timekeeping in the dorsal vagal complex

The paper shows that the dorsal vagal complex has circadian rhythms regulated by meal timing, with clock genes and their targets expressed rhythmically in vivo.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host

This study shows that daily glucocorticoids influence glioblastoma growth and circadian synchronization with the host, with effects dependent on timing and clock genes.

Light modulates glucose and lipid homeostasis via the sympathetic nervous system

This study shows that light affects glucose and lipid metabolism in mice through the sympathetic nervous system, independent of circadian rhythms, and that these effects can be reversed with light exposure.

The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus

The paper develops MITE to infer functional connectivity in the SCN and finds a conserved, sparse connectome with hubs that drive circadian synchrony.