Circadian rhythm and melatonin

Synaptic connectome of the Drosophila circadian clock

The paper maps the synaptic connectome of the Drosophila circadian clock, revealing additional neurons, contralateral connectivity, and novel peptidergic signaling.

Alternative splicing of clock transcript mediates the response of circadian clocks to temperature changes

The paper investigates temperature-sensitive alternative splicing of the clk gene in Drosophila and its role in regulating circadian clock function through phosphorylation site deletion.

ROSLT: An Improved Raspberry-Pi Open-Source Live Voluntary-Wheel Running Tracker Method and Resource

This paper introduces ROSLT, a Raspberry-Pi-based cyclometer for tracking mouse voluntary wheel running, showing it provides more accurate and consistent measurements than VDO M2.1 over time.

Neuronal progenitors suffer genotoxic stress in the Drosophila clock mutant per0.

The paper shows that lack of PER in Drosophila leads to genotoxic stress in neuronal progenitors during development.

Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats.

This study examines how circadian disruption and alcohol consumption affect gene expression in reward-related brain areas of female rats, finding distinct impacts on clock genes and inflammatory markers.

Clock genes period and timeless control synaptogenesis in Drosophila motor terminals

The paper investigates the role of clock genes period and timeless in regulating synaptogenesis and rhythmic changes in synaptic bouton numbers in Drosophila motor neurons.

Beyond Lux: Methods for Species and Photoreceptor-Specific Quantification of Ambient Light for Mammals

The paper develops methods to quantify ambient light for mammals using species-specific photoreceptor-based measurements, showing improved physiological prediction compared to lux.

Sex-specific Regulation of Fentanyl Reward by the Circadian Transcription Factor NPAS2

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

CosinorTest: An R Shiny App for Cosinor-model-based circadian and differential analysis in transcriptomic applications

CosinorTest is an R Shiny app for circadian and differential analysis of transcriptomic data using Cosinor models, offering tools for rhythmicity detection, differential pattern assessment, and visualization.

How light at night sets the circalunar clock in the marine midge Clunio marinus

This study shows how light at night influences the circalunar and circasemilunar clocks in Clunio marinus through strain-specific integration of light intensity, duration, and timing.

The period gene alters daily and seasonal timing in Ostrinia nubilalis

This study shows that genetic variation in the period gene affects daily and seasonal timing in Ostrinia nubilalis, with reduced per mRNA abundance linked to later activity and shorter diapause.

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

This study shows that age-related blood-borne factors alter circadian gene expression in cultured fibroblasts, affecting oxidative phosphorylation and cholesterol biosynthesis pathways.

Expression of Osteopontin in M2 and M4 intrinsically photosensitive retinal ganglion cells

This study identifies osteopontin expression in both M2 and M4 intrinsically photosensitive retinal ganglion cells, challenging its exclusive association with M4-ipRGC.

Regional response to light illuminance across the human hypothalamus

This study investigates how varying light levels affect different regions of the human hypothalamus during cognitive tasks, finding distinct activity patterns linked to task performance.

Brown adipose tissue thermogenesis rhythms are driven by the SCN independent of adipocyte clocks

This study shows that the SCN controls BAT thermogenesis rhythms through sympathetic signaling, independent of adipocyte clocks.

Connectomic Organization of the Suprachiasmatic Nucleus

The paper reconstructs multiscale and multimodal communication networks in the suprachiasmatic nucleus using electron microscopy, revealing unique synaptic and electrotonic structures.

Impacts of the feedback loop between sense-antisense RNAs in regulating circadian rhythms

This study revises a mathematical model to show that Per2AS and Per2 mutually repress each other, improving predictions of circadian rhythm regulation.

Detecting Rhythmic Gene Expression in Single Cell Transcriptomics

This paper benchmarks circadian detection methods on single-cell RNAseq data and proposes a subsampling and harmonic regression strategy for detecting circadian genes.

The reindeer circadian clock is rhythmic and temperature-compensated but shows evidence of weak coupling between the secondary and core molecular clock loops

A circadian clock drives behavioral activity in Antarctic krill (Euphausia superba) and provides a potential mechanism for seasonal timing

This study shows that the circadian clock in Antarctic krill drives bimodal swimming activity patterns, which may underlie seasonal behaviors like diel vertical migration.

Irregular light schedules induce alterations on daily rhythms and gene expression in mice

This study shows that brief light cycle shifts disrupt molecular circadian rhythms in mice, despite minimal behavioral changes.

Circadian modulation of mosquito host-seeking persistence by Pigment-Dispersing Factor impacts daily biting patterns

This study shows that disrupting the Pigment-Dispersing Factor in Aedes aegypti mosquitoes reduces morning biting and locomotor activity, altering daily host-seeking behavior.

An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms

The paper identifies an extra-SCN brain oscillator in the lateral amygdala that coordinates cellular and behavioral rhythms through mWAKE/ANKFN1 expression.

High distinctness of circadian rhythm is related to negative emotionality and enhanced neural processing of punishment-related information in men

This study links circadian rhythm distinctness to neural processing of punishment and traits like negative emotionality in men.

Adipocyte sphingosine kinase 1 regulates histone modifiers to disrupt circadian function

This study shows that SphK1, a circadian-regulated gene in adipocytes, affects histone modifiers and disrupts circadian function through altered histone acetylation and HDAC localization.

Chronobiological rhythms control of site- and cell-specific miRNA and mRNA genes and networks across the central nervous system

The paper identifies rhythmic mRNA and miRNA genes, networks, and co-expression pairs across CNS regions using high-dimensional data and provides a searchable resource for analysis.

Bacteria can anticipate the seasons: photoperiodism in cyanobacteria

The paper discovers that cyanobacteria can anticipate seasonal changes through photoperiodic timekeeping, involving circadian clocks and stress response mechanisms.

Photoperiodicity in Glucose Metabolism in the Human Brain

This study shows that day length affects glucose metabolism in the human brain, specifically in the cuneus, over a 5-year period in healthy males.

Circadian clock in the lateral habenula affects motor function in mice through the regulation of daily rhythms in the nigrostriatal pathway

Direct retino-iridal projections and intrinsic iris contraction mediate the pupillary light reflex in early vertebrates

The paper identifies two intrinsic mechanisms of the pupillary light reflex in lampreys, showing direct retino-iridal projections and melanopsin-mediated iris contraction, and reveals the absence of a brain-mediated PLR.