Cellular Mechanics and Interactions

This study shows that matrix stiffness in colorectal cancer alters secreted protein expression, enhancing migration, angiogenesis, and matrix remodeling, contributing to a more aggressive cancer phenotype.

The paper shows that cell divisions in the Drosophila embryo challenge and refine tissue boundaries by reducing tension and increasing cell motility.

TiFM2.0 improves mechanical measurement and actuation in live embryos with a double-probe system, demonstrating applications in chicken and zebrafish embryos.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

The paper shows that mechanical signals regulate long-range chemical signaling in the developing Xenopus brain by modulating tissue stiffness and expression of guidance cues.

This study identifies Spef1 as a microvillar component that regulates apical actomyosin contractility to maintain intestinal barrier function.

The paper uses an active matter model to simulate and reproduce actomyosin oscillations in Drosophila cells during morphogenesis, showing that cell geometry and polarity drive these dynamics.

The paper shows that Girdin links adherens junctions to actin in Drosophila tracheal cells, controlling intercalation pace and developing a genetic tool for actin depolymerisation.

This study shows that vimentin expression in breast cancer cells changes 3D cluster morphology, enhances migration, and increases cell-matrix interactions.

This paper introduces a new computational model to simulate cell monolayers and study nematic ordering and morphodynamic behaviors.

The paper uses the Cellular Potts Model to show that tension-dependent local proliferation drives curvature-driven tissue growth via surface tension, without soluble growth factors.

This study combines Traction Force Microscopy and Vinculin Tension Sensors to analyze how molecular tension and cellular tractions interact across different scales in focal adhesions.

This study investigates the R196H mutation in β-actin, showing it reduces F-actin content and cell stiffness, weakens actin-membrane attachment, and impairs cofilin interaction.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

This study shows OA chondrocytes generate higher contractile forces in 3D degradable hydrogels compared to 2D, linked to increased protrusive activity and actomyosin engagement.

This study shows how the porous structure of the extracellular matrix influences cell migration through geometric effects, introducing the concept of porotaxis.

The paper shows mechanical compression causes neuronal apoptosis, synaptic loss, and glial inflammation in GBM models, revealing pathways for neuroprotection.

The paper develops a theoretical model and experimental analysis to study how branched cells balance shape dynamics for directional decision-making during migration.

The paper identifies optimal geometric characteristics for cubically symmetric and triply periodic scaffolds to enhance cell migration by avoiding nucleus deformation and ensuring pore accessibility.

The paper identifies a novel F-actin network in Drosophila eye cells and shows its role in shaping the apical membrane through conserved actin regulatory proteins.

This study models how poroelastic properties of the extracellular matrix affect tumor growth and transport through hydrogel experiments and computational simulations.

This study investigates how stiffness and stretch affect trabecular meshwork cells using a microfluidic system, finding that glaucomatous cells show distinct mechanotransduction issues under combined mechanical stress.

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

This paper compares volume and surface methods for microparticle traction force microscopy through simulations and experiments, finding the surface method more accurate but with reduced performance at high noise levels.

This paper introduces a method to measure cellular traction forces in 3D tumoroid cultures using elastic microparticles, revealing cellular stress ranges and interactions with the extracellular matrix.

This paper introduces a heart-on-a-chip platform with ultrasoft mechanosensors to measure cell- and tissue-scale contractile stresses, showing that ECM composition affects contractility and drug responses.

This study develops a mechanobiological model to show how extracellular viscosity affects cancer cell migration through actin dynamics and adhesion, revealing a biphasic response and migration memory.

The paper develops a machine-learning framework to infer governing equations of mechano-chemical dynamics in epithelial migration from live-cell imaging data, revealing cell-cell heterogeneity in migratory rules.

This study identifies circumferential actomyosin bundles as drivers of endothelial cell deformations that regulate vessel diameter and prevent vascular malformations.