Bacterial biofilms and quorum sensing

The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA

This study shows that Sbp, a protein from S. epidermidis, binds DNA and forms biomolecular condensates, contributing to biofilm matrix organization.

A Novel Approach to Combat Pseudomonas aeruginosa: Repurposing Pharmaceuticals for Inhibition of Phospholipase A

This study identifies three pharmaceuticals that inhibit Pseudomonas aeruginosa phospholipase A, showing they reduce bacterial growth and enhance antibiotic efficacy.

Effect of C6-HSL and chlorogenic acid on spoilage characteristics of Serratia liquefaciens in mutton

This study investigates how C6-HSL and chlorogenic acid affect spoilage characteristics of Serratia liquefaciens in mutton, showing C6-HSL enhances spoilage while chlorogenic acid inhibits it.

Host-microbe-immune interactions in an air-liquid interface airway model

This paper develops a dual-cell air-liquid interface model to study epithelial-immune interactions during airway infection, finding that macrophages modulate inflammation and bacterial distribution.

Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis

This study identifies the Fsr quorum sensing system in Enterococcus faecalis as a negative regulator of biofilm growth and inflammation in infective endocarditis.

Screening of FDA-approved small molecules to discover inhibitors of the Pseudomonas aeruginosa quorum-sensing enzyme, PqsE

This study screens FDA-approved drugs to find PqsE inhibitors, identifying three molecules, including Vorinostat, which inhibits PqsE activity and may disrupt P. aeruginosa pathogenesis.

Role of Tad Pili during the transition from Planktonic to Biofilm State in Bradyrhizobium diazoefficiens USDA 110

This study investigates the role of Tad pili in biofilm formation and surface sensing in Bradyrhizobium diazoefficiens, revealing their regulatory function and connection to c-di-GMP levels.

Lipolysis of host triacylglyceride-rich lipoproteins creates a toxic microenvironment for Staphylococcus aureus

The paper shows that host-derived triacylglyceride-rich lipoproteins (TRL) can kill Staphylococcus aureus through lipolysis, revealing a potential therapeutic target for chronic infections.

The Distribution and Diversity of LuxI/LuxR Quorum Sensing Systems in Proteobacteria (Pseudomonadota)

This study provides a large-scale analysis of LuxI/LuxR quorum sensing systems in Pseudomonadota, revealing their distribution, conservation, and evolutionary dynamics across 30,000 genomes.

Plasmid transfer and loss probabilities interactively determine antibiotic resistance spread in surface-associated bacterial biomass

The paper models and experimentally tests how plasmid transfer and loss probabilities influence antibiotic resistance spread between colliding bacterial colonies.

Atypical thioredoxin Patrx2 enhances alginate production in mucoid Pseudomonas aeruginosa

This study identifies Patrx2, an atypical thioredoxin in Pseudomonas aeruginosa, which enhances alginate production in mucoid strains through redox regulation.

RsaM is not a switch but a built-in modulator of quorum sensing in Pseudomonas fuscovaginae

This study shows RsaM is not a repressor switch but a modulator that prevents overactivation of the PfsI/R quorum sensing system in Pseudomonas fuscovaginae.

Co-infection with Streptococcus and Rothia spp. drives prophage dynamics in Pseudomonas aeruginosa in an artificial sputum model

This study shows co-infection with Streptococcus and Rothia spp. reduces prophage gene expression and free phage levels in Pseudomonas aeruginosa in an artificial sputum model.

Mixed-species interactions constrain diversification and shape biofilm evolution

This study evolves three bacterial species in single- and mixed-species biofilms, showing mixed-species interactions constrain diversification while promoting specific adaptive mutations.

Small-scale biogeography of biofilms and its implications for sequencing-based studies

This study examines small-scale biogeography in biofilms and its effects on sequencing-based analyses, showing that local diversity is limited and sampling strategies impact diversity metrics and co-occurrence estimates.

Context-dependent siderophore exploitability shapes microbial community structure

The paper investigates how siderophore exploitation and spatial structure influence microbial community dynamics in iron competition.

Revealing Community Dynamics in Polymicrobial Infections through a Quantitative Framework

The paper extends a quantitative framework to assess community-level functions in polymicrobial infections, demonstrating its application to chronic wound infections and proposing a synthetic bacterial community model.

Flocculation of a cyanobacterium confers defense against bacterial predation

This study shows that cyanobacterial flocculation defends against bacterial predation by Pseudomonas aeruginosa through Type VI Secretion System-mediated nutrient access.

Strengthening Biofilms with Selective Metal Ions

This study quantifies how selective metal ions enhance the mechanical properties of bacterial biofilms by increasing elastic modulus and yield stress while reducing failure strain.

Carbon substrate type shapes spatial self-organization in a multi-species biofilm community

This study shows that carbon substrate type influences spatial organization in a synthetic bacterial community, with diffusible sugars promoting intermixing and polymers fostering structured biofilms.

A new component of the DNA damage response biofilm axis is a TetR-like DNA damage response regulator in Acinetobacter baumannii

This study identifies EppR, a TetR-family regulator, as a new component linking the DNA damage response and biofilm formation in Acinetobacter baumannii by modulating RecA levels and adhesive pili expression.

Quantifying the effects of cell death and agar density on yeast colony biofilms using an extensional-flow mathematical model

The paper uses experiments and a mathematical model to show that higher agar density increases yeast biofilm adhesion and decreases nutrient uptake.

A Novel Stress Response Pathway Mediates Antibiotic Tolerance and Architecture in Pseudomonas aeruginosa Biofilms

This study identifies BatR as a regulator of biofilm formation and antibiotic tolerance in Pseudomonas aeruginosa, showing its interaction with SrkA and role in eDNA release and pyocyanin production.

HsbA represses stationary phase biofilm formation in Pseudomonas putida

This study shows HsbA represses biofilm formation in Pseudomonas putida by inhibiting CfcR's DGC activity, regardless of its phosphorylation state, and facilitates biofilm dispersal during nutrient starvation.

Multiscale mechanics of granular biofilms

The paper characterizes the mechanical properties of pink berry granular biofilms using multiscale experiments, revealing a soft EPS matrix surrounding stiffer bacterial microcolonies.

Stochastic motility-adhesion switch within the E. coli K-12 strains revealed by gene expression clustering

The paper identifies gene expression modules linked to biofilm formation in E. coli by analyzing replicate-to-replicate variation across genetic backgrounds.

Transcriptomic responses of Vibrio campbellii to quorum sensing inhibition and antibiotic stress

This study examines the transcriptional responses of Vibrio campbellii to quorum sensing inhibition and tetracycline stress, identifying distinct gene expression patterns and pathway activations.

Retrospective analysis of Pseudomonas aeruginosa clinical isolates for secreted PrpL protease: a key virulence factor associated with corneal tissue damage

The paper retrospectively analyzes Pseudomonas aeruginosa clinical isolates to show that corneal isolates have higher PrpL protease activity and pyocyanin production, which contribute to corneal tissue damage.

Coexistence of two divergent TprA/PhrA cell-cell communication systems in Streptococcus mitis coordinate bacteriocin production, competence, oxidative stress responses, and interspecies competition with S. pneumoniae

Construction and Functional Characterization of a Heterologous Quorum Sensing Circuit in Clostridium sporogenes

This study engineers the Staphylococcus aureus agr-QS system into Clostridium sporogenes, demonstrating functional quorum sensing in an obligate anaerobe.