Bacterial biofilms and quorum sensing

A light-induced microprotein triggers regulated intramembrane proteolysis to promote photo sensing in a pathogenic bacterium.

The paper identifies DimA, a microprotein that activates photo-sensing in Pseudomonas aeruginosa by triggering proteolysis of MucA and enhancing algB expression through a positive feedback loop.

Beyond the Matrix: Rethinking Antibiotic Tolerance in CF Biofilms Using 3D Models

This study uses 3D biofilm models to show that antibiotic tolerance in Pseudomonas aeruginosa biofilms is not due to diffusion limitation but matrix-induced bacterial adaptation.

Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci

The paper shows that exposure to pyocyanin from Pseudomonas aeruginosa increases antibiotic resistance evolution in enterococci through efflux mechanisms.

Keystone engineering enables collective range expansion in microbial communities

The paper shows keystone engineering enables microbial range expansion by antibiotic-degrading bacteria, revealing spatial effects in microbial communities.

An Agent-Based Model of Metabolic Signaling Oscillations in Bacillus subtilis Biofilms

This study uses an agent-based model to simulate metabolic signaling oscillations in Bacillus subtilis biofilms, showing how cellular properties drive collective behavior and nutrient distribution.

A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917

This study shows that the bile acid lithocholic acid promotes biofilm formation by the probiotic Escherichia coli Nissle 1917, enhancing its ability to compete with pathogens.

Immune protection and disease tolerance in Pseudomonas aeruginosa infections by pyruvate cross-feeding

The paper identifies pyruvate cross-feeding as a mechanism enabling Pseudomonas aeruginosa persistence in chronic infections by modulating host immune responses and oxidative stress.

Diverse quorum sensing systems regulate microbial communication and biogeochemical processes in deep-sea cold seeps

This study identifies and characterizes quorum sensing systems in deep-sea cold seep microbial communities, revealing their role in regulating biogeochemical processes.

Tissue destruction during food spoilage is associated with the formation of biofilms by Pseudomonas species

This study investigates how Pseudomonas species spoil meat and leafy greens, finding that biofilm formation correlates with tissue destruction and spoilage capabilities.

Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection

The paper investigates how ExoY-catalyzed cGMP modulates ExoT cytotoxicity and reveals reciprocal interactions between T3SS effectors in P. aeruginosa infections.

Feeding your enemy's enemy: Acidifying bacteria inhibit pathogenic bacteria more strongly with increasing glucose

The paper demonstrates that acidifying bacteria can enhance antibiotic efficacy against pathogens by lowering pH, with stronger effects at higher glucose concentrations.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Bacterial exploration of solid/liquid interfaces: developing platforms to control the physico-chemical microenvironment

This paper develops methods to control solid-liquid interface microenvironments and study bacterial surface motility using microfluidic flow cells.

Commensal-derived short-chain fatty acids disrupt lipid membrane homeostasis in Staphylococcus aureus

This study shows that SCFAs from commensal bacteria impair S. aureus growth and virulence by disrupting BCFA metabolism and increasing antimicrobial sensitivity.

High frequency body site translocation of nosocomial Pseudomonas aeruginosa

This study investigates the translocation of Pseudomonas aeruginosa between body sites in hospitalized patients, finding that clones often move from the respiratory tract to the gut.

A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients

This study develops a mixed-species urinary catheter biofilm model from spinal cord injury patients to better understand and treat catheter-associated infections.

Microfluidics based exploration for quorum quenching genes in Antarctic microbiomes

The paper develops a microfluidics-based screening method to identify quorum quenching genes from Antarctic microbiomes, discovering a novel mechanism of QS disruption.

Differential coping strategies exerted by biofilm and planktonic cells of the beneficial bacterium B. subtilis in response to the protozoan predator Entamoeba histolytica.

This study shows that B. subtilis biofilm and planktonic cells respond differently to E. histolytica predation, with biofilms activating stress responses and planktonic cells increasing motility.

In situ profiling of bacterial growth activity during the early stages of Pseudomonas aeruginosa infection in airway epithelia

This study uses fluorescent reporters to analyze Pseudomonas aeruginosa growth activity in human airway epithelial models, revealing strain-specific colonization patterns and growth hierarchies across infection niches.

Suppressing the suppressor: Gallic acid induced asymmetric tetramerization of the pleotropic virulence factor SuhB from Pseudomonas aeruginosa abolishes its extragenic suppressor activities. A structure-based functional study

This study identifies gallic acid as an inhibitor of PaSuhB, revealing its role in suppressing bacterial growth and motility through structural and functional analysis.

Phosphorus stress and spatial confinement lower the threshold for quorum-sensing activation of redox-active metabolite production in Pseudomonas synxantha

Multifaceted suppression of staphylococcal virulence: in vitro study of a cellular status with reduced Agr activity and impaired biofilm

This study shows that sappanwood extract reduces Agr activity and biofilm in Staphylococcus aureus by suppressing virulence factors and altering extracellular components.

Predation limits the abundance of {triangleup}gacA cheaters in Pseudomonas protegens populations

The paper shows that {Delta}gacA mutants in Pseudomonas protegens are cheaters whose fitness depends on their abundance, and protozoan predators limit their spread.

Higher-order organization of bacterial cords and an amyloid-like matrix define the Mycobacterium tuberculosis biofilm

This study reveals the structural organization of Mycobacterium tuberculosis biofilms, showing how bacterial cords and an amyloid-like matrix contribute to antibiotic tolerance.

Characterization of Staphylococcus lugdunensis biofilm reveals key differences according to clonal lineage and iron availability

This study compares biofilm-forming ability and composition of Staphylococcus lugdunensis strains across clonal lineages and iron conditions, revealing differences in matrix components and identifying potential anti-biofilm targets.

From Biofilms to Biocontrol: Aquaculture Biofilms as a Reservoir of Pseudomonas spp. with Activity Against Fish and Human Pathogens

This paper identifies Pseudomonas isolates from trout aquaculture biofilms that inhibit fish and human pathogens and disrupt biofilms, suggesting potential for probiotic or antimicrobial applications.

An Electromechanical Relay-like Multi-enzymatic System Gates c-di-GMP-Dependent Cell Fate in a Cyanobacterium

The paper identifies a dual-threshold regulatory system in Anabaena PCC 7120 that controls cell fate via c-di-GMP metabolism, mediated by CdgR and involving enzymatic relays.

Quorum sensing antiactivators constrain Pseudomonas aeruginosa RhlR activity

This study investigates how QteE and QslA antiactivators modulate RhlR activity in Pseudomonas aeruginosa, revealing their distinct and overlapping roles in quorum sensing regulation.

Vibrio cholerae interaction with predatory bacteria on chitin suggests an alternative mode of biofilm formation in marine snow conditions

This study shows that chitin-bound biofilms of Vibrio cholerae are less protected against predatory bacteria than glass-bound biofilms, altering predator-prey dynamics through changes in biofilm architecture.

Stable and assayable polymicrobial human airway model reveals complex interactions between Pseudomonas aeruginosa and lung commensals

The paper develops an ATPS-based co-culture model to study polymicrobial interactions in the human airway, showing Pseudomonas aeruginosa disrupts epithelial barriers while commensals mitigate this effect.