Cellular transport and secretion

The paper investigates how distinct ESCRT complex components regulate surface expression of glutamate and GABA receptors through differential endosomal trafficking.

This study investigates the roles of CSTN1 and CSTN3 in axonal cargo transport, finding they coordinate TGN exit and regulate RAB6A levels to influence Golgi organization and trafficking.

This study investigates the interaction between LRRK1 and LRRK2, showing they modulate Rab7 activity and lysosomal exocytosis, with starvation reducing their interaction and impairing lysosomal homeostasis.

The paper identifies ACK as a regulator of LACL turnover by promoting actin branching to resolve arrested clathrin lattices in Arpc2 KO cells.

TRACEY updates SNARE protein domain annotation with improved HMMs and expanded sequence coverage, improving domain detection across species.

The paper identifies ESCRT-dependent plasma membrane remodeling as a mechanism to prevent amino acid toxicity caused by vacuole pH loss in budding yeast.

The paper identifies vesicular pseudopodia as fusion sites on large secretory vesicles in Drosophila salivary glands and shows their coordination with apical domains for efficient exocytosis.

The paper shows ESCRT proteins, specifically Snf7 and Bro1, organize stress-induced ER-Golgi contacts in yeast by forming tubular ER subdomains and recruiting tethering proteins.

This study shows that Drosophila NECAP inhibits light-induced Rhodopsin-1 internalization, preventing retinal degeneration.

This study shows that cell fusion after wounding requires plasma membrane damage and endocytosis, with endocytosis expanding fusion pores to enable tissue repair.

This study identifies signal peptides in Nannochloropsis oceanica that direct protein secretion through a periplastidial compartment and vesicle-mediated transport, revealing an evolutionarily adapted pathway.

The paper shows that neuron-specific expression of Syb2 rescues lethality and motor function in Syb1-deficient mice, demonstrating Syb2 can replace Syb1 in vivo.

This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.

The paper shows that endolysosomal damage leads to intraluminal protein condensates that prevent cytosolic leakage and sequester therapeutic oligonucleotides.

This study shows dimeric Alix nucleates CHMP4 polymerization, essential for ESCRT-III membrane remodeling, and demonstrates that dimerization is required for plasma membrane repair.

This study identifies SCM-1/SCAMP as a key factor maintaining microdomain boundaries in the endosomal system, ensuring proper cargo sorting and preventing microdomain overlap.

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.

This study shows that KNOLLE protein degradation in plant cytokinesis depends on ubiquitination, which is context-dependent and linked to membrane fusion events.

This study identifies synaptogyrin family proteins as key regulators of dopamine vesicle formation, overriding canonical synaptic vesicle size constraints and contributing to dopaminergic terminal vulnerability in Parkinson's disease.

The paper identifies ABHD13 and ABHD16A as deacylases regulating SNAP25 family proteins and maps substrate selectivity to a single amino acid position.

This study identifies TPD54 as a regulator of protein trafficking in melanoma, showing its role in disease progression and potential as a therapeutic target.

The paper identifies SNX12 as a retromer adaptor critical for HPV16 infection and shows how cargo-adaptor interactions specify retromer coat architecture through structural and functional analyses.

This paper designs synthetic fusogens using machine learning, showing they enable efficient cell-cell and intracellular membrane fusion with higher activity than native SNARE complexes.

This study tracks Synaptobrevin-1 trafficking in C. elegans neurons and identifies SAM-4 as a regulator of trafficking routes and cargo composition.

This study shows clathrin accessory proteins destabilize protein condensates while promoting clathrin lattice assembly and exclusion, revealing a mechanism linking phase separation to endocytosis.

This study identifies ER-vesicle contact sites that regulate axonal vesicle trafficking during neuronal development, showing PRG1's role in modulating vesicle retention and synapse formation.

This study shows that archaeal ESCRT-III homologue CdvB1 binds phosphoinositides and helps polarize the cytokinetic membrane in Sulfolobus acidocaldarius.

This study shows that N-type VGCCs in C. elegans are regulated by SV priming via nanodomains and UNC-13S, ensuring precise neurotransmission.