Pancreatic function and diabetes

This study develops a scalable encapsulation method for pluripotent stem cell-derived pancreatic islets, showing improved cell recovery and in vivo functionality during transplantation.

This study investigates whether morning hyperglucagonemia affects the priming effects of morning hyperinsulinemia on subsequent hepatic glucose metabolism in dogs.

This paper uses dielectrophoresis to separate insulin granule subpopulations and shows they change in response to insulinotropic signals.

This study identifies Tomosyn-2 as a regulator of β-cell maturation, showing its role in balancing proliferation and function during postnatal development.

The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.

The paper analyzes single-cell transcriptomes of human islet cells across glycemic states to identify gene expression defects in beta cells associated with type 2 diabetes.

This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.

This study shows that Otub2 modulates pancreatic beta-cell function and survival by inhibiting NFkB signaling and regulating K+ channels involved in insulin secretion.

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

This paper enhances artificial beta-cells with a PID controller to improve glucose regulation in diabetic mice.

The paper identifies Med14 phosphorylation as essential for sustained GLP-1 agonist-induced gene regulation in beta cells.

This study develops a microfluidic biosensor using pancreatic islets to monitor glucose levels in vivo, showing strong correlation between islet activity and glucose concentrations.

This study shows that prolactin receptor signaling protects beta-cells from metabolic stress by maintaining incretin receptor expression and insulin secretion.

This study evaluates if single-gene knockout of RNLS or HIVEP2 can protect β-cell grafts from allo- and xenorejection, finding no protective effects.

This study shows that restoring gap junction coupling does not fully recover functional beta-cell sub-populations under diabetogenic conditions.

This study identifies immune cell populations in the developing rat pancreas and spleen, showing IUGR disrupts their composition and is influenced by tissue environment and sex.

The paper generates and validates an AHR knockout human embryonic stem cell line to study AHR's role in islet development.

This study evaluates two β-cell network models, introduces heterogeneity based on single-cell gene expression, and incorporates paracrine signaling to improve physiological realism.

This study investigates how intrinsic metabolic and electrophysiologic properties and ionic coupling contribute to the beta hub cell phenotype in pancreatic islets.

This study identifies ΔNP63 as a marker for exocrine-committed multipotent progenitors in the murine pancreas, showing its role in exocrine development and differentiation.

This study identifies PKM1-regulated PEP metabolism as a key factor in improving functional maturation of human stem-cell derived β cells by enhancing calcium response and insulin secretion.

This study shows that GCK-MODY has diet- and duration-dependent effects on lipid profiles and kidney disease in mice, revealing long-term complications previously unrecognized.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

This study investigates the role of ER calcium stores in glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets, finding that ER mobilization is insufficient to initiate waves but required for sustained waves and connectivity.

This study shows DEC1 regulates β cell maturation and circadian rhythm in stem cell-derived islets, improving their functional maturity and glucose responsiveness.

This study investigates the roles of CgA and its derived peptides, CST and PST, in pancreatic islet function and glucose homeostasis using knockout mice, revealing their opposing effects on insulin resistance and metabolic processes.

This study investigates the rate-dependence of the first phase of glucose-stimulated insulin secretion using dynamic perifusion of human pancreatic islets, finding it follows a sigmoid function of the glucose gradient.

This study shows that Complexin 2 inhibits glucagon and somatostatin secretion and disrupts paracrine inhibition of insulin secretion in pancreatic islets.

This study shows that human stem cell-derived β-cells expressing a high-affinity CD155 variant reduce immune cell cytotoxicity, improving their potential for type 1 diabetes therapy.

This study benchmarks porcine pancreatic ductal organoids (PPDO) against human pancreatic ductal organoids (HPDO) and primary porcine pancreas using scRNA-Seq, showing PPDO's potential for drug screening with conserved toxicity profiles.