Neurological disorders and treatments

Deep brain stimulation of the nucleus accumbens shell does not decrease cocaine self-administration in cocaine-dependent rats but increases GluR1/GluA1 in the central nucleus of the amygdala

This study investigates the effects of deep brain stimulation (DBS) on cocaine self-administration in cocaine-dependent rats and finds it increases cocaine intake but raises GluR1 levels in the central nucleus of the amygdala.

Subthalamic-Cortical Network Reorganization during Parkinson's Tremor

This study identifies the neurophysiologic correlates of tremor onset and sustained tremor in Parkinson's disease using intraoperative recordings.

Inferring Deep Brain Stimulation Induced Short-term Synaptic Plasticity Using Novel Dual Optimization Algorithm

The paper develops a dual optimization algorithm to infer short-term synaptic plasticity dynamics in response to deep brain stimulation using a model-based approach and empirical data.

Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin

The paper investigates how dystonia-specific mutations in THAP1 affect gene transcription related to neurodevelopment and myelin in iPSC-derived neural cells and mouse models.

A pathogenic DYT-THAP1 dystonia mutation causes hypomyelination and loss of YY1 binding

This study shows that the DYT-THAP1 mutation F81L impairs THAP1 transcriptional activity and disrupts CNS myelination by reducing YY1 DNA binding.

Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotor movements in a mouse model of Parkinson's disease

Stable modulation of neuronal oscillations produced through brain-machine equilibrium

This study develops a closed-loop brain stimulation algorithm in parkinsonian rats that modulates beta oscillations by synchronizing stimulation with cortical activity cycles, leading to sustained changes in oscillation amplitude and locomotion.

Parkinsonian gait effects with DBS are associated with pallido-peduncular axis activation

This study investigates how specific neuronal pathways around the subthalamic nucleus affect gait in Parkinson's disease patients undergoing DBS, finding associations between pathway activation and step length changes.

Impact of stimulation location relative to grey and white matter on single pulse electrical stimulation responses in the human brain

The paper examines how stimulation location relative to grey and white matter affects single pulse electrical stimulation responses in the human brain, finding location and parameter-specific effects.

The mouse cortico-basal ganglia-thalamic network

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

A neurocomputational model of the basal ganglia for the analysis of motor deficits after dopaminergic loss in Parkinson's disease

This paper develops a neurocomputational model of the basal ganglia to study motor deficits in early-stage Parkinson's disease by simulating dopaminergic loss and its effects on motor learning.

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

The paper shows that cerebellar stimulations reduce or prevent levodopa-induced dyskinesia in mice by normalizing brain activity and reversing neuronal plasticity.

An ultra-low frequency spike timing dependent plasticity-based approach for treating alcohol use disorder

This paper introduces an ultra-low frequency spike timing dependent plasticity-based electrical stimulation approach to reduce DMS D1/D2 MSN signaling imbalances and alcohol consumption in a mouse model of AUD.

Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

The paper shows that subthalamic nucleus activity decreases during movement switches, challenging theories of movement suppression and revealing distinct neural coding for kinematics and action changes.

Convergent transcriptomic targets of propranolol and primidone identify potential biomarkers for essential tremor

This study identifies convergent transcriptomic targets of propranolol and primidone in essential tremor, highlighting potential biomarkers and molecular mechanisms for drug response.

Substantia nigra degradation results in widespread changes in medial zona incerta afferent and efferent connectomics

The paper investigates changes in the connectome of the A13 nucleus in Parkinson's disease models, finding widespread reconfiguration of afferent and efferent projections following nigrostriatal degeneration.

Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus

This study shows that PPN LFP alpha and beta oscillations are rhythmically modulated by gait phase, with spatial specificity and increased modulation in regular stepping.

Disrupted basal ganglia output during movement preparation in hemi-parkinsonian mice accounts for behavioral deficits

This study investigates how Parkinson's disease affects basal ganglia output during movement preparation in mice, finding that internal goal-based movements are more impaired than stimulus-guided ones.

No evidence for three functionally specialized subregions in the subthalamic nucleus: A model-based 7 T fMRI study

This study uses 7 T fMRI to test the tripartite model of subthalamic nucleus organization in healthy volunteers and finds no evidence for functionally distinct subregions.

Bilateral Intracranial Beta Activity during Forced and Spontaneous Movements in a Hemi-PD Rat Model

The paper evaluates motor impairments and beta oscillations in a 6-OHDA rat PD model, finding high beta power as a biomarker and DBS as a performance enhancer.

Optimal Closed-loop Deep Brain Stimulation with Multi-Contact Electrodes

This paper develops an algorithm for optimal closed-loop deep brain stimulation using multi-contact electrodes to maximize desynchronization of brain activity.

DYT-TOR1A Subcellular Proteomics Reveals Selective Vulnerability of the Nuclear Proteome to Cell Stress

This study uses subcellular proteomics to show that DYT-TOR1A mutant cells have greater nuclear proteome disruption under stress compared to other conditions.

Toward asleep DBS: Cortico basal-ganglia neural activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

The paper characterizes cortico-basal ganglia neural activity under different sedation states and compares them to sleep states to inform asleep DBS.

Movement-related changes in pallidocortical synchrony differentiate action execution and observation in humans

The paper compares movement execution and observation in Parkinson's patients by analyzing oscillatory activity and coupling in the basal ganglia-thalamocortical circuit, finding that certain network features are specific to movement execution.

Thalamic deep brain stimulation as a paradigm to reduce consciousness: implications for cortico-striatal dynamics, absence epilepsy and consciousness studies

This paper uses thalamic deep brain stimulation in macaques to manipulate consciousness, finding that it induces absence-like activity with decreased neural complexity and integration, similar to absence epilepsy.

Analysis-rcs-data: Open-source toolbox for the ingestion, time-alignment, and visualization of sense and stimulation data from the Medtronic Summit RC+S system

The paper introduces an open-source Matlab toolbox for processing and analyzing data from the Medtronic Summit RC+S neurostimulation system.

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease

This paper shows that average beta burst duration profiles reflect changes in the dynamics of beta oscillations between ON and OFF medication states in Parkinson's disease, linking them to motor impairment.

Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson Disease and OCD-like Behaviors in Mice

The paper identifies Gabrr3-expressing neurons in the STN as critical for locomotion and OCD-like behaviors in mice, showing their potential for targeted therapeutic interventions.

Movement decoding using spatio-spectral features of cortical and subcortical local field potentials

This paper develops a movement decoding pipeline using spatio-spectral features from cortical and subcortical signals, showing improved decoding with spatial information.

Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson's disease

This study examines how dopaminergic medication affects oscillatory brain networks in Parkinson's disease using combined STN and MEG recordings.