Neurological disorders and treatments

Ventralis intermedius nucleus anatomical variability assessment by MRI structural connectivity

This paper quantifies individual anatomical variability of the connectivity-defined ventralis intermedius nucleus (cd-Vim) using probabilistic tractography and finds it is more variable on the right and not influenced by methodological confounds.

Basal Ganglia Responses to Electrical Stimulation of the Posterior Hypothalamic Nucleus

This study investigates how electrical stimulation of the posterior hypothalamic nucleus affects basal ganglia activity, finding increased firing rates in some regions and decreased in others.

Activation of thalamo-cortical circuits with posterior hypothalamic nucleus deep brain stimulation

This study investigates how deep brain stimulation of the posterior hypothalamic nucleus increases neocortical excitability through thalamo-cortical circuits in rodents.

A theoretical framework for the site-specific and frequency-dependent neuronal effects of deep brain stimulation

The paper develops a computational framework to predict site-specific and frequency-dependent effects of deep brain stimulation on neuronal activity using experimental and theoretical insights.

Tractography-based targeting of ventral intermediate nucleus: A comparison between conventional stereotactic targeting and diffusion tensor imaging-based targeting

This study compares probabilistic and deterministic diffusion tensor imaging tractography with stereotactic coordinates for targeting the ventral intermediate nucleus in DBS, finding probabilistic tractography most accurate.

Basal ganglia and cortical control of thalamic rebound spikes

This study investigates how correlations in basal ganglia output affect thalamic rebound spikes and motor signal transmission using a Hodgkin-Huxley model.

Stimulation of zona incerta selectively modulates pain in humans

This study investigates the effects of zona incerta stimulation on human pain perception and finds it reduces heat pain but not other sensations.

Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of DYT1-TOR1A dystonia

This study shows that the Tor1a(ΔE) mutation in dopamine neurons reduces dopamine release, while having no effect in cholinergic neurons, indicating a cell-intrinsic role in dystonia.

Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia: chemogenetic study

This study uses chemogenetic suppression of the subthalamic nucleus in monkeys to show it reduces spike variability in the basal ganglia, leading to more stable movements.

High-frequency oscillations in the internal globus pallidus: a pathophysiological biomarker in Parkinson's disease?

This study identifies high-frequency oscillations in the internal globus pallidus as a pathophysiological feature of Parkinson's disease using clinical and preclinical data.

Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

Striatal Direct Pathway Targets Npas1+ Pallidal Neurons

This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.

Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits

The paper identifies two distinct GPe-PV neuron pathways in mice and shows they contribute to different Parkinsonian symptoms through differential electrophysiological responses to dopamine depletion.

Defining the impact of deep brain stimulation contact size and shape on neural selectivity

This study investigates how the size and shape of deep brain stimulation contacts affect neural selectivity, finding that smaller contacts better constrain activation to nearby grey matter but are less energy efficient.

Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia

The paper identifies bi-allelic variants in TSPOAP1 as a cause of autosomal recessive dystonia, showing different clinical presentations based on variant type.

Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

This study identifies distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation during a stop-signal task in humans.

Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia

This study uses human neurons to model DYT1 dystonia, revealing LMNB1 dysregulation as a key factor in disease pathology.

The sensitivity of ECG contamination to surgical implantation site in adaptive closed-loop neurostimulation systems

The paper investigates how implant location affects ECG contamination in neurostimulation systems, finding higher contamination in left-sided subclavicular implants compared to right-sided ones.

Non-invasive Amelioration of Essential Tremor via Phase-Locked Disruption of its Temporal Coherence

This paper demonstrates a method to suppress essential tremor by disrupting neural oscillation coherence through phase-locked electrical stimulation of the cerebellum.

Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders

The paper identifies differentially expressed proteins in a mouse model of DOPA-responsive dystonia, revealing shared mechanisms with human dystonic disorders.

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

This paper compares electrocorticography (ECoG) and subthalamic local field potentials (LFP) for movement decoding in Parkinson's disease, finding ECoG superior and demonstrating the impact of PD pathophysiology on decoding performance.

Changes in excitability properties of ventromedial motor thalamic neurons in 6-OHDA lesioned mice

This study investigates changes in intrinsic excitability of BGMT neurons in 6-OHDA lesioned mice, finding increased excitability due to reduced M-type potassium current.

Excitatory Deep Brain Stimulation Quenches Parkinsonian Signs in the Basal Ganglia and Thalamus

This study uses a computational model of the basal ganglia to show that excitatory deep brain stimulation (EDBS) reduces pathological beta oscillations in Parkinson's disease, while inhibitory DBS does not.

Frequency matters: Up- and Down-Regulation of Dopamine Tone Induces Similar Frequency Shifts in Cortico-Basal Ganglia Beta Oscillations

The paper shows that dopamine levels affect beta oscillation frequency, not power or coherence, in cortico-basal ganglia networks of NHPs and PD patients.

A disynaptic circuit in the globus pallidus controls locomotion inhibition

This study identifies a disynaptic circuit in the globus pallidus involving arkypallidal neurons that inhibits locomotion.

Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo.

The paper investigates synaptic inputs to two subpopulations of neurons in the mouse external Globus Pallidus, revealing distinct connectivity patterns from the striatum and subthalamic nucleus.

A Metabolomic Study of Cervical Dystonia

This study conducts a metabolomics analysis of cervical dystonia, identifying 289 significant metabolic differences and 9 associated biological pathways.

Neurofeedback linked suppression of subthalamic beta oscillations speeds up movement initialisation in Parkinsonian Patients

This study shows that neurofeedback training reduces STN beta bursts and improves movement speed in Parkinson's patients.

Network fingerprint of stimulation induced speech impairment in essential tremor

The paper identifies structural brain fibers associated with speech impairment caused by deep brain stimulation in essential tremor patients and shows their predictive value for intelligibility changes.

Deep brain stimulation modulates the dynamics of resting-state networks in patients with Parkinson's Disease

This study uses fMRI to analyze how STN-DBS affects resting-state networks in PD patients, finding increased DMN occurrence and VN stability related to stimulation location.