Neurological disorders and treatments

Modelling Instantaneous Firing Rate of DBS Target Neuronal Ensembles in Basal Ganglia and Thalamus

The paper develops a mathematical model to quantify neuronal firing rate dynamics in basal ganglia and thalamus during DBS across different frequencies, showing consistent parameter fitting with both synthetic and experimental data.

Neural underpinnings of action adaptation in the subthalamic nucleus.

This study investigates how subthalamic nucleus activity modulates action adaptation in Parkinson's patients during a force adaptation task, finding that reduced beta activity correlates with better adaptation.

Spontaneous pauses in firing of external pallidum neurons are associated with exploratory behavior

The paper links spontaneous firing pauses in external pallidum neurons to exploratory behavior through increased saccade rate and pupil dilation.

Functional abnormalities in the cerebello-thalamic pathways in an animal model of dystonia

A mouse model of DYT25 dystonia with a Gnal mutation shows altered cerebello-thalamic plasticity, which can be modulated by theta-burst stimulation to reduce dystonia severity.

Focal electrical stimulation on an alcohol disorder model using MRI-compatible chronic neural monopolar carbon fiber electrodes.

This paper describes a method for constructing and using MRI-compatible carbon fiber electrodes in rats to study neuromodulation effects on alcohol use disorder.

Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain

This paper demonstrates a multiscale co-simulation approach combining a spiking basal ganglia model with a whole-brain mean-field model to predict the effects of virtual deep brain stimulation in Parkinson's disease.

High-and Low-Frequency Deep Brain Stimulation in the Subthalamic Nucleus differentially modulate Response Inhibition and Action Selection in Parkinson's Disease

This study compares high- and low-frequency DBS in the STN on response inhibition and action selection in PD using eye-tracking and EEG, finding differential effects on impulsivity.

Pathophysiology of Dyt1 dystonia is mediated by spinal cord dysfunction

This study shows that spinal cord dysfunction contributes to DYT1 dystonia by creating mouse models with dystonia-like symptoms.

Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks

This study uses a biophysical model to show how deep brain stimulation (DBS) of the subthalamic nucleus can restore normal striatal rhythms in Parkinson's disease by modulating fast spiking interneurons and cortical noise.

Conflict detection in a sequential decision task is associated with increased cortico-subthalamic coherence and prolonged subthalamic oscillatory response in the beta band.

The paper examines neural correlates of conflict and evidence integration during sequential decision making, finding increased cortico-subthalamic coherence and prolonged subthalamic beta oscillations during conflict.

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

The paper uses ECAP features to classify electrode locations in the STN and surrounding regions to improve DBS therapy for Parkinson's disease.

Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict

The paper constructs a biophysically detailed model of the STN-GPe network to investigate how theta band activity and spiking in the subthalamic nucleus arise during response conflict.

Analysis of human brain tissue derived from DBS surgery

The paper describes a method to collect brain tissue from DBS surgical instruments for transcriptomic and proteomic analysis, showing it provides reliable data comparable to traditional brain tissue samples.

Single-neuron bursts encode pathological oscillations in Parkinson's disease and essential tremor

This study links single-neuron bursting to pathophysiological LFP oscillations in Parkinson's disease and essential tremor using intracranial recordings.

Deep brain stimulation creates information lesion through membrane depolarization

This study shows that deep brain stimulation (DBS) causes membrane depolarization in hippocampal neurons, impairing their ability to process inputs and creating an information lesion.

Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.

This study identifies Sst+ GPi neurons that provide feedback to basal ganglia nodes and influence behavioral flexibility during learning.

Dopamine depletion can be predicted by the aperiodic component of subthalamic local field potentials

This study shows that aperiodic components of subthalamic local field potentials can predict dopamine depletion in Parkinson's disease and improve machine learning predictions of pathological activity.

State Dependency of Beta Oscillations in the Cortico-Basal-Ganglia Circuit and their Neuromodulation under Phase Locked Inputs

This paper demonstrates how connectivity in the cortico-basal-ganglia circuit influences beta oscillations and shows that phase-locked stimulation can modulate these oscillations based on network state.

Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus

The paper maps connectivity and identifies functionally distinct cell types in the subthalamic nucleus using mouse and human data.

Hyperdirect connectivity of opercular speech network to the subthalamic nucleus

This study identifies hyperdirect connectivity between opercular speech regions and the subthalamic nucleus in humans using intracranial recordings during deep brain stimulation.

Transient response of basal ganglia network in healthy and low-dopamine state

This study uses a network model of the basal ganglia to show that low-dopamine state alters transient responses and oscillatory activity through changes in direct pathway and recurrent connectivity within the globus pallidus externa.

Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings

The paper identifies speech-induced artifacts in intracranial recordings and shows they correlate with speech audio and vibration patterns.

Deep Brain Stimulation for Parkinson's Disease Induces Spontaneous Cortical Hypersynchrony In Extended Motor and Cognitive Networks

This study uses machine learning and spectral graph theory to show that DBS increases high beta-gamma synchrony in a cortical network involving motor and cognitive areas.

Stimulation related artifacts and a multipurpose template-based offline removal solution for a novel sensing-enabled deep brain stimulation device

This paper identifies artifacts in neural signals from a DBS device during stimulation and presents an offline removal method using template subtraction.

Estimation of Periodic Signals with Applications to Deep Brain Stimulation

This paper introduces a periodic artifact removal algorithm for DBS signals with missing data and high-frequency stimulation, enabling real-time biomarker discovery in closed-loop DBS systems.

Cortico-subcortical β burst dynamics underlying movement cancellation in humans

The paper investigates β burst dynamics in cortico-subcortical networks during movement cancellation in humans, finding that subcortical β-bursts precede cortical β-bursts and increase on successful stop trials.

NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA

The paper shows that NAc-DBS alleviates depression-like behaviors in CUMS mice by disinhibiting VTA-DA neurons through modulation of GABA and VTA-GABA activity.

Improved alpha-beta power reduction via combined Electrical and Ultrasonic stimulation in a Parkinsonian Cortex-Basal Ganglia-Thalamus Computational Model

This paper uses a computational model to show that combined electrical and ultrasonic stimulation reduces beta power in Parkinsonian brain networks more effectively than single modalities.

Input zone-selective dysrhythmia in motor thalamus after dopamine depletion

This study investigates thalamic dysrhythmia in Parkinsonism by comparing activity in dopamine-intact and 6-OHDA-lesioned rats, finding zone-selective abnormalities in the basal ganglia-recipient zone.

Deep brain stimulation of the nucleus accumbens shell does not decrease cocaine self-administration in cocaine-dependent rats but increases GluR1/GluA1 in the central nucleus of the amygdala

This study investigates the effects of deep brain stimulation (DBS) on cocaine self-administration in cocaine-dependent rats and finds it increases cocaine intake but raises GluR1 levels in the central nucleus of the amygdala.