Spinal Cord Injury Research

An inertial sensor-based comprehensive analysis of manual wheelchair user mobility during daily life in people with SCI

This study analyzes daily mobility patterns of manual wheelchair users with SCI using inertial sensors, revealing key metrics and consistent mobility behaviors across participants.

Loss of 5-HT2C Receptor Function Alters Motor Behavior in Male and Female Mice With and Without Spinal Cord Injury

This study examines the role of the 5-HT2C receptor in motor behavior of mice with and without spinal cord injury, finding sex- and injury-dependent changes in receptor expression and function.

Prolonged Heat Treated Mesenchymal Precursor Cells Induce Positive Outcomes Following Transplantation in Cervical Spinal Cord Injury.

This study shows that dead mesenchymal precursor cells from prolonged heat treatment provide functional and anatomical benefits in spinal cord injury models, suggesting they may be useful for non-transplantation cell therapies.

Combining cortical and spinal stimulation maximizes improvement of gait after spinal cord injury

This study shows that combining cortical and spinal stimulation improves gait recovery in rats with spinal cord injury more than either method alone.

REVS: A New Open-Source Platform for High-Resolution Analysis of Rodent Wheel Running Behavior

REVS is an open-source platform for analyzing rodent wheel running behavior, providing detailed metrics and customizable hardware for behavioral phenotyping in injury and recovery studies.

Functional recovery by transplantation of human iPSC-derived A2B5 positive neural progenitor cell after spinal cord injury in mice

The paper demonstrates that hiPSC-derived A2B5+ NPCs can survive, differentiate into neurons and astrocytes, and improve functional recovery after spinal cord injury in mice.

Astrocytic MAOB-GABA axis as a molecular brake on repair following spinal cord injury

This study identifies the astrocytic MAOB-GABA axis as a brake on spinal cord injury repair and shows that the inhibitor KDS2010 promotes recovery in animal models and has a safe profile in humans.

Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model

This paper introduces a custom electromagnetic impactor device for creating consistent contusion spinal cord injuries in pigs, validated through mechanical modeling and histological confirmation.

Modulation of biphasic pattern of cortical reorganization in spinal cord transected rats by external magnetic fields.

The paper shows that 32 days of ELF-MF exposure improves functional recovery and modulates plasticity proteins in SCI rats, but not after shorter exposures.

KCC2 Enhancers Normalize Reflex Responses and Improve Locomotor Function after Chronic Spinal Cord Injury

This study shows that enhancing KCC2 activity normalizes reflex responses and improves locomotor function in chronic spinal cord injury rats.

Altered excitability of dI3 neurons regulates hindlimb motor tone and locomotor recovery after spinal cord injury

This study shows that altering dI3 neuron excitability affects hindlimb motor tone and locomotor recovery after spinal cord injury, with combined serotonergic agonist and dI3 stimulation improving recovery.

Intrathecal administration of palmitoyl-lysophosphatidylethanolamine reduces secondary injury and improves locomotor recovery following spinal cord injury

This study shows that intrathecal administration of palmitoyl-LPE reduces secondary injury and improves locomotor recovery after spinal cord injury in mice.

Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function

This study shows that cervical SCI in rats impairs aerobic fitness, muscle endurance, and cardiovascular function through various stress tests.

Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury

This study investigates sex-dependent effects of PADs on neutrophil function and recovery after spinal cord injury using inhibitors and knockout mice.

Nanoparticles loaded with a CSF1R antagonist selectively depletes microglial cells and modulates inflammation in spinal cord injury

This study shows that PLX5622-loaded nanoparticles selectively deplete M1-like microglia and reduce inflammation in spinal cord injury models.

Activation of Endogenous Spinal Cord Stem Cell Mediates Recovery Induced by Olfactory Ensheathing Cell Transplantation Following Spinal Cord Injury

This study shows that olfactory ensheathing cell transplantation promotes spinal cord recovery by activating endogenous ependymal cells, enhancing their proliferation and supporting axonal growth.

Molecular pathology of acute spinal cord injury in middle-aged mice

This study compares transcriptomic and histopathological outcomes in young and middle-aged mice after spinal cord injury, finding similar recovery but differences in cell subpopulations.

Daily electric field treatment improves functional outcomes after thoracic contusion spinal cord injury in rats

This study shows that a thin-film implant with supercapacitive electrodes improves hind limb function and touch sensitivity in rats with thoracic SCI without causing neuroinflammation.

The Pathological Role and Therapeutic potential of ALDH2 in acrolein detoxification Following Spinal Cord Injury in Mice

This study investigates ALDH2's role in SCI by genetically impairing and pharmacologically enhancing its activity, showing Alda-1 reduces acrolein levels and improves recovery, especially in ALDH2*2 mice.

L-selectin shedding regulates functional recovery and neutrophil clearance following spinal cord injury in a sex-dependent manner

This study shows that L-selectin shedding improves functional recovery and white matter sparing in female mice but not males after spinal cord injury, with sex-dependent effects on neutrophil clearance.

Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

This study uses computational models to explore how spinal neural connectivity reorganizes after thoracic spinal cord injury in rats, identifying key circuit-level changes that enable recovery.

Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury

This study shows that enhancing astrocytic Kir4.1 function reduces spasticity in SCI mice by improving K+ uptake and preventing neuronal hyperexcitability.

Inhibition of the RNA Regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation

This study shows that inhibiting HuR with SRI-42127 reduces neuroinflammation and improves functional outcomes after spinal cord injury.

EFFECTS OF SPINAL TRANSECTION AND LOCOMOTOR SPEED ON MUSCLE SYNERGIES OF THE CAT HINDLIMB

This study examines how spinal transection and locomotor speed affect muscle synergies in cat hindlimbs, finding that while specific synergies change, the overall organization remains consistent.

Combined Transplantation of Mesenchymal Progenitor and Neural Stem Cells to repair cervical spinal cord injury.

This study shows that combining mesenchymal progenitor cell and neural stem cell transplantation improves outcomes after spinal cord injury by enhancing NSC survival and oligodendrocyte differentiation through early inflammatory modulation.

Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury

This study shows that Ryk signaling in astrocytes regulates scar formation and wound healing after spinal cord injury by coordinating cellular responses and inflammation resolution.

Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI

This study identifies RORβ neurons as a target to limit hyperreflexia and enhance locomotor function after spinal cord injury using combination treatment.

Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord

This study investigates how transplanted neural progenitor cell-derived neurons integrate into spinal cord locomotor circuits and their functional impact on motor recovery after injury.

Spinal cord injury in rats disrupts thermoregulation and suppresses stress-induced hyperthermia

This study shows that spinal cord injury in rats disrupts stress-induced hyperthermia, which recovers over time.

Conditioning electrical stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury