Spinal Cord Injury Research

High-Low training is safe and effective in improving outcomes in a rodent model of chronic cervical spinal cord injury.

This study shows that High-Low training improves respiratory function and reduces anxiety-like behaviors in a rodent model of chronic spinal cord injury.

Cervical Repetitive Magnetic Stimulation Enhances Respiratory Recovery by Modulating Neuronal Plasticity After Cervical Spinal Cord Injury

Cervical repetitive magnetic stimulation improves ventilatory recovery after spinal cord injury by enhancing diaphragm activity and reducing inflammation.

Tau Signaling in Injured Spinal Cord

This study shows that cervical spinal cord injury increases phosphorylated tau without changing total tau levels, with effects extending beyond the injury site.

Hapln1-HA signaling promotes progenitor cell proliferation and spinal cord regeneration

This study identifies Hapln1-HA signaling as a pro-regenerative mechanism in zebrafish spinal cord injury by enhancing progenitor cell proliferation and repair.

Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury

Rehabilitation drives functional reorganization of intact corticospinal-supraspinal projections following partial spinal cord injury

This paper shows that rehabilitation after spinal cord injury promotes specific reorganization of corticospinal pathways in medullary motor nuclei, improving motor function.

Proteomic analysis reveals shared biological pathways linking acrolein to biomolecular changes in the acute phase of rat spinal cord injury

The paper uses proteomic analysis to identify acrolein-induced changes in rat spinal cord injury, revealing shared pathways in complement and coagulation cascades.

Systemic delivery of drug-free polymeric nanoparticles reprograms innate immunity in a sex-dependent manner after spinal cord injury

This study shows that drug-free polymeric nanoparticles improve locomotor recovery after spinal cord injury in both sexes through sex-specific immune mechanisms.

Unbiased Quantification of Persistent Postural and Motor Deficits Following Spinal Cord Injury in Mice

This study quantifies persistent postural and motor deficits after spinal cord injury in mice using unbiased, high-speed video tracking and machine learning.

Disrupted Inhibitory-Excitatory Balance Underlies Spinal Motoneuron Dysfunction in Incomplete Spinal Cord Injury

This study identifies altered inhibitory-excitatory balance as a key mechanism causing motoneuron dysfunction in incomplete spinal cord injury.

Comparative Neuroprotective Effects of Minocycline and Bone Marrow Mononuclear Cells After Complete Spinal Cord Transection in Adult Rats

This study compares the neuroprotective effects of minocycline and bone marrow mononuclear cells after spinal cord injury in rats, showing they target different aspects of secondary injury.

Effect of endogenous and exogenous ketosis in acute spinal cord injury in Wistar rats.

This study investigates the effects of endogenous and exogenous ketosis on spinal cord injury in rats, finding that ketosis enhances anti-inflammatory and antioxidant responses when combined with methylprednisolone.

Characterizing Mitochondrial Dysfunction Across Time in a Porcine model of Spinal Cord Injury

The paper characterizes mitochondrial dysfunction at different time points after spinal cord injury in male pigs to understand its temporal progression and potential therapeutic targets.

Spontaneous axon regeneration is preserved despite gut microbiota disruption after spinal cord injury in lampreys

The paper examines whether gut microbiota changes after spinal cord injury affect axon regeneration in lampreys, finding no impact on spontaneous regeneration.

Microtubule Stabilization and Biomaterial Guidance Synergize to Enhance CST Regeneration and Motor Recovery After Chronic SCI.

This study combines biomaterial scaffolds and microtubule stabilizers to improve axon regeneration and motor recovery in chronic spinal cord injury.

DLK inhibition has sex-specific effects on neuroprotection and locomotor recovery after spinal cord injury

This study shows that DLK inhibition after spinal cord injury improves neuroprotection in female mice but worsens recovery and increases lesion size in males.

in vivo Reprogramming of NG2 Glia Improves Bladder Function After Spinal Cord Injury

This study shows that reprogramming NG2 glia with SOX2 improves bladder function in a mouse model of spinal cord injury by promoting neurogenesis and reducing glial scarring.

Virtual prototyping of non-invasive spinal cord electrical stimulation targeting upper limb motor function

The paper develops a computational model to simulate tSCS effects on motor function, finding that somatosensory afferents have lower thresholds than motor efferents, and that anode placement and waveform type influence recruitment patterns.

Unveiling Distinct Neuroimmune Responses in Mouse Models of Cervical Spinal Cord Injury: Hemisection versus Hemicontusion

This study compares neuroimmune responses in two cervical spinal cord injury models in mice, finding distinct inflammatory and repair profiles between hemisection and hemi-contusion injuries.

Curcumin Promotes Myelin Repair after Spinal Cord Injury via Spatially Selective Regulation of CLASP2 Phosphorylation

This study shows curcumin promotes myelin repair after spinal cord injury by selectively regulating CLASP2 phosphorylation, enhancing cytoskeletal organization and remyelination.

Biologically-Constrained Spiking Neural Network for Neuromodulation in Locomotor Recovery after Spinal Cord Injury

This paper develops a biologically constrained spiking neural network to model neuromodulation effects on locomotor recovery after spinal cord injury, finding that reducing GABAergic inhibition improves movement coordination.

A Translational Preclinical Strategy for Chronic Spinal Cord Injury: Neuroprotective and Regenerative Potential of Botulinum Neurotoxin Type A combined with Muscle Atrophy Prevention via Electrostimulation

This study shows that combining botulinum neurotoxin type A with electrical muscle stimulation improves motor function and reduces neuropathic pain in chronic spinal cord injury.

Early Changes in Respiration and Motor Activity after Spinal Cord Injury Predict Pain-Related Outcomes in Mice

This study shows that early post-injury changes in mouse respiration and motor activity can predict future pain-related outcomes after spinal cord injury.

Effect of Biceps Brachii Muscle Stimulation on Respiration before and after Cervical Spinal Cord Injury.

This study shows that biceps brachii stimulation can enhance phrenic motor output in rats with cervical spinal cord injuries, suggesting a spinal mechanism for breathing recovery.

ADGRG1 blockade drives astrocyte positioning into the extracellular matrix to reduce scar size

This study shows that blocking ADGRG1 allows astrocytes to enter the fibrotic matrix, reducing scar size and improving motor recovery after CNS injury.

Early blood-spinal cord barrier stabilization preserves peri-lesional tissue and improves recovery after SCI

This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.

Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice

This study identifies a hypothalamic-pontine-spinal pathway that promotes locomotion and functional recovery after spinal cord injury in mice through optogenetic manipulation and deep brain stimulation.

Altered therapeutic capacities of olfactory ensheathing cells caused by a lesion in an autologous transplantation model for the treatment of spinal cord injury.

This study shows that olfactory ensheathing cells from previously injured animals have reduced therapeutic potential in spinal cord injury treatment compared to healthy donor cells.

Poly-L-Ornithine Coated Plant Scaffolds Support Motor Recovery in Rats after Traumatic Spinal Cord Injury

This study shows that poly-L-ornithine-coated plant scaffolds improve motor recovery and neural repair in rats with spinal cord injury.

Changes in cerebral glucose metabolism at rest following hemicontusive spinal cord injury in mice: A whole-brain autoradiographic study

This study uses whole-brain autoradiographic mapping to show changes in glucose metabolism in mice following spinal cord injury, revealing both decreased and increased metabolic activity in different brain regions.