Hypothalamic control of reproductive hormones

Highly redundant neuropeptide volume cotransmission underlying episodic activation of the GnRH neuron dendron

The paper shows that kisspeptin, not other co-transmitters, activates GnRH neuron dendrons, and that its deletion abolishes episodic hormone secretion despite preserved KNDy neuron synchronization.

Activation of Kiss1 neurons in the preoptic hypothalamus stimulates testosterone synthesis in adult male mice

The paper shows that male mice have nearly as many Kiss1RP3V neurons as females, which can stimulate testosterone synthesis when activated.

Mutant screen for reproduction unveils depression-associated Piccolo's control over reproductive behavior

The paper identifies Pclo mutations in rats that affect reproductive behavior and link to depression-associated genes.

Spexin and a novel cichlid-specific spexin paralog both inhibit FSH and LH through a specific galanin receptor (Galr2b) in tilapia

The paper identifies two spexin paralogs in tilapia that inhibit FSH and LH via Galr2b, revealing their role in the brain-pituitary-gonad axis.

Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice

The paper shows that optogenetic stimulation of MePD kisspeptin neurons in female mice increases LH pulse frequency, suggesting their role in regulating the GnRH pulse generator.

Gli3 regulates vomeronasal neurogenesis, olfactory ensheathing cell formation, and GnRH-1 neuronal migration.

This study shows Gli3 is critical for olfactory ensheathing cell development and GnRH-1 neuronal migration, and identifies a GLI3 mutation in a Kallmann syndrome patient.

Neuroprogesterone signals through Src kinase within RP3V neurons to induce the luteinizing hormone surge in female rats

The paper investigates the role of neuroprogesterone signaling through Src kinase in RP3V neurons to trigger the luteinizing hormone surge in female rats.

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

RP3V kisspeptin neurons mediate neuroprogesterone induction of the luteinizing hormone surge in female rat

This study shows that neuroprogesterone induces the LH surge via RP3V kisspeptin neurons in female rats by restoring the surge when kisspeptin is administered.

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.

NKB Signaling in the Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent Manner in Female Mice

This study shows that NKB signaling in the medial amygdala stimulates gonadotropin release in female mice independently of kisspeptin.

MiR-505-3p is a Repressor of the Puberty Onset in Female Mice

This study identifies miR-505-3p as a repressor of puberty onset in female mice, showing delayed puberty and reduced fertility with its overexpression and earlier puberty with its knockout.

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

This study identifies 78 genetic signals for male puberty timing using a large sample of men, revealing links to hair color and health outcomes.

PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

This study identifies PACAP-expressing neurons in the ventral premammillary nucleus that regulate reproductive function in female mice by modulating kisspeptin neurons.

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

This study performs a GWAS meta-analysis of menstrual cycle length in European women, confirming the FSHB locus association and identifying four novel signals linked to the HPG axis.

Elucidating the genetic architecture of reproductive ageing in the Japanese population

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.

Genetic and Environmental Influences on Pubertal Hormones in Human Hair across Development

The paper estimates genetic and environmental influences on testosterone, DHEA, and progesterone concentrations in human hair across 8-18 years in twins, identifying sex-specific heritability peaks.

Sex-biased transcriptomic response of the reproductive axis to stress

The paper investigates how stress affects the HPG axis transcriptome in rock doves, finding females show more differential gene expression than males.

Widespread patterns of sexually dimorphic gene expression in an avian hypothalamic-pituitary-gonadal (HPG) axis

This study identifies sex-biased gene expression patterns in the HPG axis of rock doves, revealing tissue-specific differences in reproductive-related genes.

Olfactory and vomeronasal innervation of the olfactory bulbs are not essential for GnRH-1 neuronal migration to the brain.

This study shows that proper olfactory bulb development and olfactory/vomeronasal axonal connections are not required for GnRH-1 neuronal migration to the hypothalamus.