Hypothalamic control of reproductive hormones

Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction

This study profiles GnRH neurons in mice to uncover developmental gene expression patterns linked to human reproductive processes.

Dynamics of Pulsatile Activities of Arcuate Kisspeptin Neurons in Aging Female Mice

This study uses chronic in vivo Ca2+ imaging to track pulsatile activity of kisspeptin neurons in aging female mice, revealing robust frequency patterns but declining intensity during reproductive senescence.

Role of membrane estrogen receptor alpha on the positive feedback of estrogens on LH secretion

The paper investigates the role of membrane estrogen receptor alpha in the positive feedback of estrogens on LH secretion using E4 and C451A-ER mice.

Posterodorsal medial amygdala urocortin-3, GABA and glutamate mediate suppression of LH pulsatility in female mice

This study shows that MePD Ucn3 neurons suppress LH pulsatility via GABA and glutamate signaling and modulate HPA/HPG axes through projections to the PVN in female mice.

Female-Specific Pituitary Hypersensitivity to Gonadotropin-Releasing Hormone in a Mouse Model of Chronic Temporal Lobe Epilepsy

The paper examines changes in pituitary function in a mouse model of chronic temporal lobe epilepsy, finding increased GnRH sensitivity and gene expression in females but no significant changes in LH or FSH levels.

A pituitary gene network linking vgll3 to regulators of sexual maturation in male Atlantic salmon

The paper identifies a gene regulatory network in Atlantic salmon linking vgll3 to regulators of sexual maturation, suggesting alternative mechanisms to GnRH1 in controlling c-jun and sf1 expression.

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

POU6F2 mutation identified in humans with pubertal failure shifts isoform formation and alters GnRH transcript expression

The paper identifies POU6F2 mutations in IHH patients, showing isoform1 regulates GnRH expression and variants disrupt this function, contributing to pubertal failure.

Brain Atlas for Glycoprotein Hormone Receptors at Single-Transcript Level

The paper creates a comprehensive neuroanatomical atlas of glycoprotein hormone receptor expression in the brain using single-transcript detection technologies.

Sex-specific association between urinary kisspeptin and pubertal development

The paper investigates the association between urinary kisspeptin concentrations and pubertal development in children, finding sex-specific differences and potential for non-invasive assessment.

Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption

The paper investigates GABA transmission to GnRH neurons in an epilepsy mouse model, finding sex-specific changes linked to estrous cycle disruption.

Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity

The paper investigates whether GnRH neuron firing in female mice with epilepsy correlates with seizure severity and finds no such relationship.

Role of posterodorsal medial amygdala urocortin-3 in pubertal timing in female mice

This study shows that psychosocial stress delays puberty and increases anxiety in female mice by affecting Urocortin3 neurons in the medial amygdala.

Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice.

This study shows that maternal immune activation accelerates puberty and alters pain sensitivity in mice, with environmental enrichment mitigating some effects.

In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

The paper uses in vivo calcium imaging to show KNDy neurons synchronize in a temporal order before LH pulses, revealing a structured activation pattern in the GnRH pulse generator.

Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

Modulation of pulsatile GnRH dynamics across the ovarian cycle: the role of glutamatergic transmission in the arcuate kisspeptin network.

The paper investigates how glutamatergic transmission modulates GnRH pulsatility in the arcuate kisspeptin network across the estrous cycle using optogenetics and mathematical modeling.

A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia

This study identifies a recessive PRDM13 mutation causing congenital hypogonadotropic hypogonadism and cerebellar hypoplasia through mouse models and human expression analysis.

Reproductive neuronal circuitry in adaptive changes of energy balance

The paper identifies leptin-hyperpolarized neurons in the PMv that coexpress DAT and prolactin receptor, and shows they inhibit reproduction via AgRP, with computational modeling linking these findings to metabolic control of reproduction.

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

The paper investigates how pubertal sex hormones regulate transcriptional changes in the medial preoptic area of mice during puberty, revealing sexually dimorphic gene regulatory networks.

Prenatal androgen treatment does not alter the firing activity of hypothalamic arcuate kisspeptin neurons in female mice

This study investigates whether prenatal androgen treatment affects the firing activity of hypothalamic arcuate kisspeptin neurons in female mice, finding no significant differences in firing rates across age groups.

Selective ablation of adult GFAP-expressing tanycytes leads to hypogonadotropic hypogonadism in males

This study shows that selective ablation of adult hypothalamic GFAP-expressing tanycytes causes hypogonadotropic hypogonadism in males by reducing GnRH neurons and testosterone levels.

A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output

The paper investigates the role of GFAP-expressing astrocytes in regulating GnRH and KNDy neuron activity and LH release, finding that Gq signaling in the preoptic area increases LH release and GnRH firing.

Estradiol-induced progesterone synthesis develops post-puberty in the rostral hypothalamus and coincides with post-pubertal changes in the steroidogenic pathway in female mouse hypothalamic astrocytes

This study shows that estradiol-induced progesterone synthesis in the rostral hypothalamus develops post-puberty in female mice and correlates with increased membrane ER expression in hypothalamic astrocytes.

Balanced release of neuropeptide FF and gonadotropin-releasing hormone 3 modulates male sexual behavior

The paper shows that balanced release of NPFF and GnRH in TN-GnRH neurons modulates male sexual behavior in medaka, with double knockout showing normal behavior.

Lack of sex differences in gonadotropin-releasing hormone (GnRH) neuron potassium currents and excitability

This study investigates sex differences in GnRH neuron potassium currents and excitability under homeostatic feedback conditions, finding no significant differences between sexes.

The structural and electrophysiological properties of progesterone receptor expressing neurons vary along the anterior-posterior axis of the ventromedial hypothalamus and undergo local changes across the reproductive cycle

The paper examines how progesterone receptor expressing neurons in the VMHvl change structurally and electrophysiologically along the anterior-posterior axis and across the reproductive cycle.

The E3 ubiquitin ligase RNF216/TRIAD3 is a central regulator of the hypothalamic-pituitary-gonadal axis

This study investigates the role of RNF216/TRIAD3 in the hypothalamic-pituitary-gonadal axis using cell line and mouse models, finding sex-specific effects on reproductive function.

Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression

The paper shows that EED represses Kdm6b, increasing H3K27me3 and reducing gene expression in a puberty-activating network.

Food and temperature change photoperiodic responses in two vole species: different roles for hypothalamic genes

This study investigates how food scarcity and temperature affect photoperiodic responses in voles, revealing species-specific hypothalamic gene regulation of reproductive development.