Sleep and Wakefulness Research

Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington's Disease

The paper examines sex differences in sleep patterns in BACHD mice, finding male mice show more sleep fragmentation and rhythm variability than females.

Neuronal ensembles in visual cortex reactivate during hypnagogic sleep onset

The paper shows that neuronal ensembles in visual cortex are reactivated during hypnagogic sleep onset after prolonged visual stimulation.

REM sleep has minute-scale rhythms in mice and humans: A non-binary continuum between phasic and tonic microstates

Elevated estradiol during a hormone simulated pseudopregnancy decreases sleep and increases hypothalamic activation in female Syrian hamsters

Response of sleep slow oscillations to acoustic stimulation is evidenced by distinctive synchronization processes

The paper examines how acoustic stimulation during sleep affects slow wave synchronization, identifying distinct event types and their responses to stimulation.

Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

The paper compares optogenetic and pharmacological induction of sleep in Drosophila, finding they activate distinct transcriptional programs.

Made together, replayed together: Memory consolidation during sleep involves context reinstatement in humans

The paper investigates how context influences memory consolidation during sleep by testing recall changes for non-cued objects linked to cued objects through spatial memory tasks.

Polyamine elevation and nitrogen stress are toxic hallmarks of chronic sleep loss in Drosophila melanogaster

This study identifies polyamine elevation and nitrogen stress as toxic consequences of chronic sleep loss in Drosophila, linking them to metabolic dysfunction and reduced survival.

Ontogenesis of the molecular response to sleep loss

The paper examines how sleep deprivation affects gene expression in the prefrontal cortex of developing mice, identifying age-dependent changes in gene categories.

Respiration shapes sleep-oscillations and memory reactivation in humans.

This study shows respiration modulates sleep oscillations and memory reactivation in humans by enhancing slow oscillations, spindles, and their coupling during inhalation peaks.

A sleep-active neuron can promote survival while sleep behavior is disturbed

This study shows that the RIS neuron in C. elegans can enhance survival even when sleep behavior is disrupted, suggesting survival and sleep are separable functions of sleep neurons.

Boosting sleep slow waves suppresses dreaming

This study uses closed-loop auditory stimulation to show that boosting slow oscillations during NREM sleep reduces dreaming likelihood.

Memory systems integration in sleep complements rapid systems consolidation in wakefulness

The paper shows that sleep enhances memory retention and brain activity in specific regions for memories consolidated during wakefulness, and that sleep integrates memory systems complementary to wakefulness consolidation.

Sleep spindles favor emotion regulation over memory consolidation of stressors in PTSD

The paper investigates how NREM sleep spindles affect emotion regulation and memory consolidation in PTSD after stress exposure, finding increased spindles correlate with reduced anxiety but poorer memory recall.

Emotional memories are enhanced when reactivated in slow wave sleep, but impaired when reactivated in REM

The paper investigates how emotional memory consolidation during sleep stages affects memory retention, finding that reactivating memories during slow wave sleep enhances them, while reactivation during REM impairs them.

Detection of neuronal OFF periods as low amplitude neural activity segments

The paper identifies low amplitude neural activity segments during NREM sleep as OFF periods, showing they have distinct characteristics and new properties like vigilance-state-dependent duration.

Sleep-dependent structural neuroplasticity after a spatial navigation task: A diffusion imaging study

This study investigates sleep-dependent structural neuroplasticity using diffusion imaging, finding rapid remodelling of neurites and glial cells after spatial navigation learning.

Sleep/wake changes in perturbational complexity in rats and mice

This paper validates the Perturbational Complexity Index (PCIst) in rats and mice, showing it reliably reflects consciousness states and is influenced by deep cortical layer stimulation.

In vivo Locus Coeruleus activity while awake is associated with REM sleep quality in healthy older individuals

This study finds that higher locus coeruleus activity during wakefulness in older adults is linked to worse sleep quality and reduced theta band power during REM sleep.

An Infant Sleep Electroencephalographic Marker of Thalamocortical Connectivity Predicts Behavioral Outcome in Late Infancy

This paper identifies spindle density in infant sleep EEG as a biomarker predicting later behavioral outcomes, while other features like slow wave slope and coupling are not predictive.

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice

This study shows that clozapine-N-oxide and compound 21 affect sleep in mice, suggesting that chemogenetic actuators may have off-target effects beyond DREADD receptor activation.

Item-specific memory reactivation during sleep supports memory consolidation in humans

This study identifies item-specific memory reactivation during slow-wave sleep using EEG and shows its role in memory consolidation.

Sleep does not influence schema-facilitated motor memory consolidation

This study investigates whether sleep after learning a motor schema enhances memory consolidation, but finds no significant effect on performance or correlation with sleep features.

An invariant relationship between NonREM and REM sleep and the wave model of their dynamics.

The paper introduces a wave model that quantitatively captures the dynamics of NonREM and REM sleep and predicts an invariant relationship between their duration and intensity.

Activity in developing prefrontal cortex is shaped by sleep and sensory experience

The paper shows that neural activity in developing rat prefrontal cortex increases during active sleep and movement, driven by sensory feedback, contrasting with previous anesthetized studies.

How coupled slow oscillations, spindles and ripples control neuronal processing and communication during human sleep

The paper shows how slow oscillations, spindles, and ripples coordinate to enhance neuronal firing rates, cross-correlations, and cross-regional interactions during human sleep.

Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleep

The paper identifies GPI-anchor biosynthesis as a conserved regulator of sleep through variant-to-gene mapping and cross-species genetic screening in humans and model organisms.

Pupil dynamics-derived sleep stage classification of a head-fixed mouse using a recurrent neural network

This paper classifies sleep stages in head-fixed mice using pupil dynamics and an LSTM model, achieving higher accuracy than a feed forward neural network.

Updating memories of unwanted emotions during human sleep

The paper shows that presenting positive words during NREM sleep can reduce negative affect judgments of unwanted memories, associated with changes in theta and sigma brain activity.

Distinction between slow waves and delta waves sheds light to sleep homeostasis and their association to hippocampal sharp waves ripples

The paper distinguishes between slow waves and delta waves during NREM sleep, showing type-1 slow waves are homeostatically regulated and linked to down states, while type-2 slow waves confuse the timing of hippocampal sharp-wave ripples.