Sleep and Wakefulness Research

A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain

This study identifies a genetic variant in ADORA2A associated with alpha power in EEG and A1 adenosine receptor availability in the human brain, with sex-specific effects observed.

Spindle-dependent memory consolidation in healthy adults: A meta-analysis

This paper conducts a meta-analysis of 53 studies to examine the relationship between sleep spindles and memory performance, finding a small to moderate effect with stronger associations for procedural memory.

Multivariate prediction of cognitive performance from the sleep electroencephalogram

The paper predicts cognitive performance from sleep EEG features in older men, finding that certain EEG patterns are associated with cognitive ability, though this association weakens after adjusting for demographic and health factors.

Beta spectral power during sleep is associated with impaired recall of extinguished fear

This study links increased beta band spectral power during sleep to impaired recall of extinguished fear in both healthy individuals and PTSD patients.

Hawkes process modeling quantifies complicated firing behaviors of cortical neurons during sleep and wakefulness

The paper uses Hawkes process modeling to quantify cortical neuron firing patterns during sleep and wakefulness, finding that non-REM sleep increases firing intensity and shortens repetitive firing periods.

Noribogaine effects on wakefulness and sleep

This study investigates the effects of noribogaine on sleep and wakefulness in rats, finding it promotes wakefulness and reduces slow-wave and REM sleep.

Microglia Regulate Sleep via Calcium-Dependent Modulation of Norepinephrine Transmission

This study shows microglia regulate sleep through Gi-coupled signaling, Ca2+ signaling, and suppression of norepinephrine transmission.

Episodic long-term memory formation during slow-wave sleep

The paper tests if novel vocabulary is encoded during slow-wave sleep and identifies neural events that support memory formation.

Activation of basal forebrain astrocytes induces wakefulness without compensatory changes in sleep drive

This study shows that activating basal forebrain astrocytes increases wakefulness without increasing sleep drive, suggesting sleep regulation involves specific neuronal-glial circuits.

Noradrenergic Tone is Not Required for Neuronal Activity-Induced Rebound Sleep in Zebrafish

The paper investigates the role of noradrenergic tone in rebound sleep following neuronal activation in zebrafish, finding that reducing noradrenergic tone enhances rebound sleep.

Pontine waves accompanied by short hippocampal sharp wave-ripples during non-rapid eye movement sleep

This study investigates P-waves during NREM sleep, showing they share short-term dynamics with REM sleep P-waves but differ in longer-term cholinergic dynamics and hippocampal coupling.

Sleep Need, the Key Regulator of Sleep Homeostasis, Is Indicated and Controlled by Phosphorylation of Threonine 221 in Salt Inducible Kinase 3

This study identifies SIK3 T221 phosphorylation as an indicator and controller of sleep need, showing reduced sleep need in mutants and after sleep deprivation.

A neuropsychological basis for temptation-resistant voluntary exercise

This study identifies hypothalamic hypocretin/orexin neurons as responsible for prioritizing exercise over temptations in mice.

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

The paper investigates the association between brainstem myelin content and sleep parameters in healthy young men, finding significant links between myelin integrity and sleep quality metrics.

Hypnotic treatment reverses NREM sleep disruption and EEG desynchronization in a mouse model of Fragile X syndrome to rescue memory consolidation deficits.

Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

This study investigates the role of hypocretin neurons in social behavior using fiber photometry and optogenetics in mice, revealing sex-dependent effects on social interaction.

Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex

The paper investigates how sleep deprivation affects neural processing in rat auditory cortex, finding sleep-like changes such as increased population synchrony and silent periods.

Oscillatory-Quality of sleep spindles: from properties to function

This study introduces a new metric, oscillatory Quality (o-Quality), to quantify sleep spindle oscillatory strength in mice and links it to functional roles in sleep.

Targeted memory reactivation in human REM sleep elicits detectable reactivation

This study uses targeted memory reactivation to detect memory reactivation in human REM sleep, finding it mediated by high theta activity and linked to improved overnight performance.

Theta and alpha EEG oscillations reflect sleep need -- except during the wake maintenance zone

The paper shows that theta and alpha EEG oscillation amplitudes reflect accumulated sleep need during wakefulness, but not during the wake maintenance zone.

Control and coding of pupil size by hypothalamic orexin neurons

This study investigates the role of hypothalamic orexin neurons in controlling pupil size, linking their activity to arousal and reward states through specific stimulation and in vivo recordings.

Biochemical and chemical biological approaches to mammalian sleep: roles of calcineurin in site-specific dephosphorylation and sleep regulation

This study identifies calcineurin as a phosphatase that dephosphorylates SIK3 at specific sites, linking it to sleep regulation in mice.

Divergent associations of slow-wave sleep vs. REM sleep with plasma amyloid-beta

This study examines how slow-wave sleep and REM sleep affect plasma amyloid-beta levels, finding distinct associations with growth hormone, cortisol, and age-related clearance efficiency.

Peripheral vs. Core Body Temperature as Hypocretin/Orexin Neurons Degenerate: Exercise Mitigates Increased Heat Loss

This study shows that Hcrt/Ox neuron degeneration increases heat loss by reducing sympathetic vasoconstrictor tone, and that exercise mitigates this effect in mice.

Striatal dopamine regulates sleep states and narcolepsy-cataplexy

This study investigates the role of striatal dopamine in regulating sleep states and cataplexy using a murine model of narcolepsy.

Multi-channel recordings reveal age-related differences in the sleep of juvenile and adult zebra finches

The paper examines age-related changes in sleep patterns and neural activity in zebra finches, finding differences in sleep stages and functional connectivity between juveniles and adults.

Noradrenergic locus coeruleus activity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle

This study shows that LC activity partitions NREM sleep into brain and autonomic states that regulate the NREM-REM cycle, with high activity enabling microarousals and low activity required for REMS entries.

Neuromodulation via muscarinic acetylcholine pathway can facilitate distinct, complementary, and sequential roles for NREM and REM states during sleep-dependent memory consolidation

The paper uses a computational model and in vivo recordings to show NREM and REM sleep have distinct roles in memory consolidation, with NREM expanding memory traces and REM preventing overlap.

Invariant relationship unites REM and NonREM sleep.

The paper identifies an invariant relationship between NREM sleep duration and REM sleep intensity across normal sleep cycles.

Does targeted memory reactivation during NREM sleep require complementary REM sleep for memory consolidation?

This study investigates whether REM sleep is necessary for memory consolidation after NREM sleep targeted memory reactivation (TMR), finding that TMR benefits depend on the timing relative to REM sleep.