Sleep and Wakefulness Research

NREM consolidation and increased spindle counts improve age-related memory impairments and hippocampal representations

This study shows that acute sleep restriction improves memory and sleep quality in old mice but worsens these outcomes in young mice.

State-dependent pontine ensemble dynamics and interactions with cortex across sleep states

This study investigates state-dependent dynamics of pontine ensembles and their interactions with the cortex across sleep states in mice, revealing distinct functional roles of sleep.

Understanding the interplay of sleep and aging: Methodological challenges

The paper identifies and addresses methodological challenges in studying sleep and aging using electrophysiological and brain structural data from younger and older adults.

One-shot tagging during wake and cueing during sleep with spatiotemporal patterns of transcranial electrical stimulation can boost long-term metamemory of individual episodes in humans

Aberrant synaptic release underlies sleep/wake transition deficits in a mouse Vamp2 mutant

This study identifies a Vamp2 mutation in mice that causes sleep-wake transition deficits by reducing synaptic release probability.

Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats

This study shows that the orexin/hypocretin system modulates social play behavior in juvenile rats by affecting ORX-A neuron activity and ORX-1 receptor function.

Sharp wave-ripples in human amygdala and their coordination with hippocampus during NREM sleep

This study identifies sharp wave-ripples in human amygdala during NREM sleep and shows their coordination with hippocampal activity, supporting a role in emotional memory consolidation.

Reward does not facilitate visual perceptual learning until sleep occurs

This study shows that reward during training interacts with sleep to enhance visual perceptual learning offline performance gains.

Memory quality modulates the effect of aging on memory consolidation during sleep: Reduced maintenance but intact gain

The paper shows that aging affects memory consolidation during sleep, but only for memories with medium encoding quality, while weakly encoded memories remain unaffected.

Pathway-dependent regulation of sleep dynamics in a network model of the sleep-wake cycle

The paper uses a simplified network model to show how pathway-specific synaptic manipulations affect sleep-wake dynamics, revealing pathway-dependent regulation of sleep states.

Epidermal Growth Factor signaling acts directly and through a sedation neuron to depolarizes a sleep-active neuron following cellular stress

The paper identifies EGFR signaling in the RIS neuron and its indirect activation via the ALA neuron as mechanisms for sleep induction following cellular stress in C. elegans.

Sleep homeostasis reflects temporally integrated local cortical neuronal activity

This study develops mathematical models of sleep homeostasis in mice, showing Process S integrates local cortical neuronal activity over time to regulate sleep quantity.

Low acetylcholine during early sleep is important for motor memory consolidation

This study shows that low acetylcholine during early sleep supports motor memory consolidation, as increasing acetylcholine impairs motor skill retention.

The gap junction blocker mefloquine impairs sleep-dependent declarative memory consolidation in humans

This study shows that mefloquine, a gap junction blocker, impairs sleep-dependent declarative memory consolidation in humans but not procedural memory.

Decreased electrocortical temporal complexity distinguishes sleep from wakefulness

The paper uses permutation entropy to show that electrocortical complexity decreases during sleep compared to wakefulness in rats, suggesting a global thalamo-cortical pattern change.

Cholinergic switch between two different types of slow waves in cerebral cortex

The paper identifies two types of slow waves in the cerebral cortex, showing they differ in neural dynamics and sensitivity to stimuli, explaining differences in memory consolidation under sleep and anesthesia.

Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations

The paper shows that preserved cortical excitability during wakefulness is linked to better cognitive performance in older adults, independent of brain structural changes.

Stimulation augments spike sequence replay and memory consolidation during slow-wave sleep

This study uses computational models to show that sensory stimulation during specific phases of slow-wave sleep enhances memory consolidation by affecting slow-wave patterns and replay.

Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium

The paper examines how self-reported sleep relates to hippocampal atrophy across adulthood using data from the Lifebrain consortium and UK Biobank, finding that worse sleep is linked to faster hippocampal volume loss over time.

Neurophysiological predictors of memory impairment in schizophrenia: decoupled slow-wave dynamics during non-REM sleep

The paper identifies impaired slow-wave and spindle coordination during NREM sleep in schizophrenia patients as predictors of memory consolidation deficits.

Fear in dreams and in wakefulness: evidence for day/night affective homeostasis

This study investigates the relationship between fear in dreams and emotional responses during wakefulness, finding that more fear in dreams correlates with reduced fear responses in specific brain regions during wakefulness.

Night watch during REM sleep for the first-night effect

This study investigates whether REM sleep exhibits a night-watch system similar to NREM sleep during the first-night effect, finding increased vigilance in both hemispheres during REM's phasic period.

On the development of sleep states in the first weeks of life

This study uses machine learning to analyze EEG complexity and sleep stages in newborns, showing rapid developmental changes in NREM and REM sleep.

Paternally expressed imprinted Snord116 and Peg3 regulate hypothalamic orexin neurons

This study investigates the role of the paternally expressed Snord116 gene in hypothalamic orexin neurons and its impact on sleep and metabolic functions in mice with paternal deletion of Snord116.

Social context and dominance status contribute to sleep patterns and quality in groups of freely-moving mice

This study examines how social context and dominance status affect sleep patterns and quality in socially housed mice using wireless EEG and video tracking.

The flower pot method of REM sleep deprivation causes apoptotic cell death in the hepatocytes of rat

This study shows that REM sleep deprivation in rats causes hepatocyte apoptosis, which is partially reversed with sleep recovery.

The paternally imprinted gene Snord116 regulates cortical neuronal activity

This study investigates the role of Snord116 in regulating sleep patterns and cortical neuronal activity in a PWS mouse model, finding abnormalities in REM sleep and sleep spindles.

Noninvasive Sleep Scoring in Mice using Electric Field Sensors

This paper develops and validates noninvasive electric field sensors for accurate 3-state sleep scoring in mice, achieving high agreement with expert EEG/EMG scoring.

REM negatively predicts statistical learning but not other forms of gist

The paper investigates how different types of gist are affected by sleep, finding that REM sleep negatively impacts statistical learning but not inferential gist.

Galanin neurons in the hypothalamus link sleep homeostasis, body temperature and actions of the alpha2 adrenergic agonist dexmedetomidine

This study shows that galanin neurons in the hypothalamus regulate sleep homeostasis, body temperature, and the effects of dexmedetomidine.