Sleep and Wakefulness Research

Changes in cross-frequency coupling following closed-loop auditory stimulation in non-rapid eye movement sleep

This study shows that closed-loop auditory stimulation during NREM sleep changes cross-frequency coupling in specific brain regions, suggesting potential for modulating sleep-dependent memory formation.

Adolescent sleep is critical for the developmental shaping of social novelty preference

This study shows that adolescent sleep disruption impairs adult social novelty preference, with NREM and REM sleep affecting sociality and novelty preference respectively.

Reassessing the validity of slow-wave dynamics as a proxy for NREM sleep homeostasis

The paper re-evaluates slow-wave dynamics as a proxy for NREM sleep homeostasis, finding distinct delta-wave types with different responses to sleep deprivation and recovery.

Exaggerated postnatal surge of orexin and the effects of elimination of excess orexinon blood pressure in spontaneously hypertensive rats in postnatal development

This study shows that an exaggerated postnatal surge of orexin neurons in SHRs contributes to higher blood pressure, and reducing these neurons lowers blood pressure.

Integrity of corpus callosum is essential for the cross-hemispheric propagation of sleep slow waves: a high-density EEG study in split-brain patients

Autonomic/Central Coupling Boosts Working Memory in Healthy Young Adults

This study shows that coordinated autonomic and central events during sleep predict working memory improvement in young adults.

mPFC Spindle Cycles Organize Sparse Thalamic Activation and Recently Active CA1 cells During non-REM Sleep

The paper investigates how thalamic activity during non-REM sleep is coordinated with cortical spindles and hippocampal SWRs in rats, suggesting a role in memory integration.

Susceptibility to auditory closed-loop stimulation of sleep slow oscillations changes with age

This study examines how auditory closed-loop stimulation affects sleep slow oscillations and memory in older adults compared to younger adults, finding no memory benefit but reduced stimulation effects in older subjects.

Consolidation of reward memory during sleep does not require dopaminergic activation

This study investigates whether dopaminergic activation is needed for preferential consolidation of reward-related memories during sleep, finding no evidence for such a requirement.

Dopamine-gated memory selection during slow wave sleep

This study investigates how dopamine affects memory consolidation during sleep, finding that it enhances forgetting of weak memories and increases slow wave sleep duration.

The role of the hypothalamus in cortical arousaland sleep homeostasis

This study shows that hypothalamic stimulation increases cortical activity and accelerates sleep pressure buildup, indicating the hypothalamus regulates both state transitions and within-state arousal intensity.

Basal forebrain parvalbumin neurons mediate arousals from sleep induced by hypercarbia or auditory stimuli

This study identifies BF parvalbumin neurons as a key component of the brain circuitry mediating brief arousals from sleep in response to internal and external stimuli.

Sleep and Diurnal Rest-Activity Rhythm Disturbances in a Mouse Model of Alzheimer's Disease

This study examines sleep and rest-activity rhythm disturbances in J20 Alzheimer's disease mice and evaluates the effects of mGluR5 inhibitors on these phenotypes.

Haplotype of the astrocytic water channel AQP4 modulates slow wave energy in human NREM sleep

This study links an AQP4 haplotype to variations in NREM slow wave energy and cognitive performance during wakefulness in humans.

A salt-induced kinase (SIK) is required for the metabolic regulation of sleep

This study identifies KIN-29, a C. elegans SIK homolog, as essential for metabolic regulation of sleep by linking energy deficits to sleep promotion through nuclear actions in sensory neurons.

Phase-based coordination of hippocampal and neocortical oscillations during human sleep

The paper identifies three classes of phase-based communication between hippocampal and neocortical regions during sleep, highlighting the role of hippocampal slow oscillations in memory consolidation.

pumilio regulates sleep homeostasis in response to chronic sleep deprivation in Drosophila melanogaster

This study shows that Pumilio is essential for sleep rebound, particularly after chronic sleep deprivation in Drosophila, by modulating neuronal excitability.

Dual Orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

This study shows that ablating both orexin and MCH neurons in mice leads to increased wakefulness, reduced sleep, and more severe cataplexy compared to ablating orexin neurons alone.

A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum

The paper introduces composite EEG measures for NREM sleep based on power law scaling, reducing 191 metrics to four, and shows their utility in characterizing age, sex, and intelligence effects.

Locus-coeruleus norepinephrine activity gates sensory-evoked awakenings from sleep

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.

Chronic antidepressant treatments rescue reduced REM sleep theta power in a rat social defeat stress model of depression

This study investigates how chronic antidepressant treatments affect REM sleep theta power in a rat model of depression, finding that they increase theta power while reducing REM duration and bouts.

Local Targeted Memory Reactivation in Human Sleep

This study shows that targeted memory reactivation during sleep improves memory for specific words associated with local brain activity, modulating slow wave activity in the cued hemisphere.

Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

This study investigates how ventral striatopallidal neurons modulate orexin/hypocretin neuron activity in response to food and metabolic states, revealing their role in reward-seeking behavior.

Sleep Deprivation alters the influence of biological sex on active-phase sleep behavior

This study investigates how biological sex influences active-phase sleep behavior in mice, finding that sex chromosome complement affects sleep recovery but not spontaneous sleep.

Electrocortical temporal complexity during wakefulness and sleep: an updated account

This study shows that electrocortical temporal complexity decreases during sleep regardless of electrode configuration, suggesting brain-generated differences in complexity between wakefulness and sleep.

A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep

The paper identifies wake-active neurons that depolarize sleep-active neurons to initiate sleep in C. elegans by coordinating locomotion circuits during lethargus.

Sleep differentially affects early and late neuronal responses to sounds in auditory and perirhinal cortices

The paper examines how sleep affects neuronal responses to sounds in auditory and perirhinal cortices, finding greater attenuation in perirhinal cortex during NREM and REM sleep.

Does Sleep Protect Memories Against Interference? A Failure to Replicate

This study fails to replicate the claim that sleep protects memories against retroactive interference, finding no difference in interference effects between sleep and wake conditions.

Sleep’s impact on emotional memory: A meta-analysis of whole-night, nap, and REM sleep effects

This study meta-analyzes sleep's effect on emotional memory consolidation, finding no overall benefit for emotional material but suggesting stage-specific effects.

INSULIN-LIKE GROWTH FACTOR I MODULATES VULNERABILITY TO STRESS THROUGH OREXIN NEURONS

This study shows that IGF-I modulates stress vulnerability via orexin neurons, with Firoc mice lacking IGF-I receptors in these neurons showing heightened fear responses and PTSD-like behaviors.